- Education and Training
MD - Tulane University School of Medicine, New Orleans, LA
Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA
Pediatric Hematology-Oncology -The Children's Hospital of Philadelphia, Philadelphia, PA
MPH - Tulane University School of Public Health & Tropical Medicine, New Orleans, LA
- Titles and Academic Titles
Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
- Conditions Treated
- Centers and Programs
- Research Interests
Pediatric low grade gliomas
Opsoclonus myoclonus ataxia syndrome
Minturn JE, Sievert AJ. Pediatric brain tumors. In: Florin T, Ludwig S. Netter's pediatrics. Philadelphia: Saunders; 2011.
Sievert AJ, Lang SS, Silva A, Brewington D, Mueller S, Haas-Kogan DA, Storm PB, Resnick AC. Rationale for combinatorial therapeutics to inhibit BRAF fusion activation. Mol Cancer Ther. Nov 2013. 12:B272, doi:10.1158/1535-7163.
Lang SS, Sievert AJ, Boucher KL, Madsen PJ, Slaunwhite E, Brewington D, Storm PB, Resnick AC. Development of pediatric glioma models for BRAF-targeted therapy. Neurosurgery. 2012 Aug; 71 (2): E575.
Sievert AJ, Lang SS, Boucher K, Slaunwhite E, Brewington D, Madsen P, Storm PB, and Resnick AC. Characterization of KIAA1549-BRAF Fusion responsiveness to selective BRAF inhibition. Neuro-Oncology. Abstracts from the 15th International Symposium on Pediatric Neuro-Oncology. 2012 June: i1-i168.
Sievert AJ, Lang SS, Storm PB, Resnick AC. Mechanisms of resistance of BRAF fusions to first generation selective BRAF inhibitors [abstract]. Molecularly Targeted Therapies: Mechanisms of Resistance- American Association of Cancer Research; 2012 May 9-12; San Diego, CA.
Karajannis MA, Legault G, Fisher MJ, Milla SS, Cohen KJ, Wisoff JH, Harter DH, Goldbery JD, Hochman T, Merkelson A, Bloom MC, Sievert AJ, Resnick AC, Dhall G, Jones DTW, Korshunov A, Pfister SM, Eberhart CG, Zagzag D, and Allen JC. Phase II study of sorafenib in children with recurrent or progressive low-grade astrocytomas. Neuro Oncol. 2014 May 6. [Epub ahead of print]. PMID: 24803676
Sievert AJ, Lang SS, Boucher KL, Madsen PJ, Slaunwhite E, Choudhari N, Kellet M, Storm PB, and Resnick AC. Paradoxical activation and RAF inhibitor resistance of BRAF protein kinase fusions characterizing pediatric astrocytomas. PNAS 2013 April; 110 (15): 5957-5962. Epub 2013 Mar 26. PMID: 23533272
Stephens, J, Sievert AJ, Judkins AR, Resnick AC, Storm PB, Rushing E, Santi M. Spinal cord ependymomas and myxopapillary ependymomas in the first two decades of life: a clinicopathological and immunohistochemical characterization of 19 cases. J of Neurosurg Pediatr. 2012 Jun; 9 (6):646-53. PMID: 22656257
Posters and Presentations
Lectures by Invitation
Waanders, AJ. “Opsoclonus Myoclonus Ataxia Syndrome,” Chair Clinical Conference, The Children’s Hospital of Philadelphia, Philadelphia, PA, May 2014.
Waanders, AJ. “Congenital brain tumors,” Abington Memorial Hospital Neonatology Grand Rounds, Abington Township, PA, November 2013.
Waanders, AJ. “Paradoxical activation and RAF inhibitor resistance of BRAF protein kinase fusions characterizing pediatric astrocytomas,” 2013 Pediatric Neuro-Oncology Basic and Translational Research Conference, Fort Lauderdale, FL, May 2013.
- Awards and Honors
2014- present, Sanford Endowed Chair for Pediatric Oncology Research
2009, Prize- CHOP Research Poster Day
1999-2003, Adopt-A-Student Scholarship, Tulane University SOM
1996, Philosophy Department Senior Student Award
1992-1996, Alpha Lambda Delta Honorary Society
1992-1996, Medallion and HEIS Scholarships for Academic Excellence
- Editorial and Academic Positions
2013- present, Reviewer- Molecular Cancer Therapeutics
2012- present, Reviewer- Journal of Neuro-Oncology
2011- present, Reviewer- Pediatric Blood and Cancer
2014- present, St. Baldrick’s Foundation, Grant Review Committee
2011- present, Pediatric Protocol Review Committee, Division of Oncology, Children’s Hospital of Philadelphia
Memberships in Professional Organizations
2013- present, Co-Investigator, Pacific Pediatric Neuro-Oncology Consortium
2009- 2012, Pediatric Brain Tumor Consortium
2008- present, American Association for Cancer Research
2007- present, Society of Neuro-Oncology
2007- present, Children’s Oncology Group
2006- present, American Society of Pediatric Hematology/Oncology
2006-present, American Society of Clinical Oncology
- Awards and Honors