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Mei-Lun Wang, MD

Attending Physician

Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Abstracts

2013

Muir AB, Toltzis S, Noah Y, and Wang ML: Esophageal epithelial cells acquire functional characteristics of activated myofibroblasts in vitro following the development of EMT. Oral presentation at the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. October 2013.

Whelan KA, Chang S, Muir AB, Masterson J, Benitez AJ, Tetreault MP, Crissey MA, Kong J, Gimotty PA, Falk GW, Katz JP, Lynch JP, Furuta GT, Wang ML, and Nakagawa H.: Autophagy may facilitate epithelial-mesenchymal transition in eosinophilic esophagitis and genetically engineered mouse models of esophagitis. Oral presentation at Digestive Diseases Week of the American Gastroenterologic Association. Orlando, FL May 2013.

Muir AB, Toltzis S, Modayur PC, and Wang ML.: Altered wound healing properties in esophageal epithelial cells that have undergone EMT. Digestive Diseases Week of the American Gastroenterologic Association. Orlando, FL May 2013.

Modayur PC, Lee AJ, Tait-Wojno E, Benitez AJ, Muir AB, Toltzis S, Shen D, Noah Y, de Waal Malefyt R, Artis D, and Wang ML. : Preferential expression and food antigen-mediated induction of thymic stromal lymphopoietin in differentiated esophageal epithelial cells in eosinophilic esophagitis. Oral Presentation at Digestive Diseases Week of the American Gastroenterologic Association. Orlando, FL May 2013.

2012

Muir AB, Lim DM, and Wang ML: Esophageal epithelial and mesenchymal cross talk leads to features of EMT in vitro. Oral Presentation at Digestive Diseases Week of the American Gastroenterologic Association, San Diego, CA May 2012.

Modayur PC, Mehta I, Toltzis S, Lim DM, and Wang ML: Environmental triggers of TSLP expression in human esophageal epithelial cells. Poster of Distinction, Digestive Diseases Week of the American Gastroenterologic Association, San Diego, CA May 2012.

Menard-Katcher C, Hand N, Zahm A, Benitez A, Wang ML, and Friedman JR: MicroRNAs are altered in eosinophilic esophagitis. Digestive Diseases Week of the American Gastroenterologic Association, San Diego, CA May 2012.

2011

Modayur PC, Lim DM, Tait-Wojno E, and Wang ML: Toll like receptor 3 signaling facilitates esophageal epithelial adhesion to the eosinophil-like cell line HL60 in vitro. North American Society for Gastroenterology, Hepatology, and Nutrition, Orlando, FL October 2011.

Lim DM and Wang ML.: Toll like receptor 3 signaling enables human esophageal epithelial cells to sense endogenous danger signals released by necrotic cells. Digestive Diseases Week of the American Gastroenterologic Association. Chicago, IL May 2011.

2009

Lim DM, Lombardi L, Michaylira CZ, Wang ML. Functional characterization of TLR3 signaling in immortalized nontransformed human esophogeal epithelial cells [presentation]. American Gastroenterological Association Digestive Diseases Week; 2009 May; Chicago IL.

2008

Wang ML, Saling L, Michaylira C, Rustgi AK, Cash-Mason T. Acid pH primes the innate epithelial response to LPS in the esophageal epithelium [presentation]. American Gastroenterological Society Digestive Diseases Week; 2008 May; San Diego, CA. 

Awards

2013, Faculty Honor Roll, The Children's Hospital of Philadelphia
2012-2015, American Partnership For Eosinophilic Disorders (APFED) and HOPE Research Award
2012, 2013, Fellows' Faculty Honor Roll, Division of GI, Hepatology, and Nutrition, The Children's Hospital of Philadelphia
2008, Faculty Honor Roll, Children's Hospital of Philadelphia
2002, Gastroenterology Research Group/American Gastroenterological Association Fellow Travel Award to attend Digestive Diseases Week in San Francisco, CA
1991, Phi Beta Kappa
1991, Golden Key National Honor Society
1987-1991, College Scholar, College of Arts and Sciences, Cornell University

Books

Chapters

2008

Wang ML, Rustgi AK. Polyps and polyposis syndromes. In: Liacouras CA, Piccoli DA, editors. Pediatric gastroenterology: the requisites in pediatrics. Philadelphia: Mosby Elsevier; 2008: 192.

2003

Wang M. Neonatal cholestasis (conjugated hyperbilirubinemia). In: Migita DS, Christakis DA , editors. Saint-Frances guide to pediatrics. Philadelphia: Lippincott Williams and Wilkins; 2003: (26)143-48.

Wang M: Gastrointestinal bleeding. In: Migita DS, Christakis DA, editors. Saint-Frances guide to pediatrics. Philadelphia: Lippincott Williams and Wilkins; 2003: (90) 482-86.

Wang M: Inflammatory bowel disease. In: Migita DS, Christakis DA, editors. Saint-Frances guide to pediatrics. Philadelphia: Lippincott Williams and Wilkins; 2003: (88) 471-77.

2002

Wang M, Maller E. A case of hepatosplenomegaly. In: Pediatric case reviews 2. Philadelphia: Lippincott Williams and Wilkins; 2002: 79-86.

Editorial and Academic Positions

Editorial positions

2013-present, Reviewer, PLOS One

2012, Reviewer: Gastroesophageal Reflux (GER) and Gastroesophageal Reflux Disease (GERD) in Infants, fact sheets developed by the National Digestive Diseases Information Clearinghouse, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

2011-present, Reviewer, Innate Immunity

2012-present, Reviewer, American Journal of Physiology, GI, and Liver Physiology

2009-present, Reviewer, Gastroenterology

Academic and institutional committees

2013-present, Protective Immunity and Immunopathology Affinity Group
2011-present, Research Steering Committee, Division of GI, Hepatology, and Nutrition

Leadership

Memberships in professional organizations

2001-present, American Gastroenterological Association 
2000-present, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
1998-present, American Board of Pediatrics

Original Papers

2013

Siracusa MD, Saenz SA, Tait Wojno ED, Kim BS, Osborne LC, Ziegler C, Benitez AJ, Ruymann KR, Farber DL, Sleiman PM, Hakonarson H, Cianferoni A, Wang ML, Spergel JM, Comeau MR, and Artis D: TSLP-mediated extramedullary hematopoiesis promotes allergic inflammation. Immunity In press, In press 2013.

Noti M, Tait-Wojno ED, Kim BS, Siracusa MC, Giacomin PR, Nair MG, Benitez AJ, Ruymann KR, Muir AB, Hill DA, Chikwava KR, Moghaddam AE, Sattentau QJ, Alex A, Zhou C, Yearley JH, Menard-Katcher P, Kubo M, Obata-Ninomiya K, Karasuyama H, Comeau MR, Brown-Whitehorn T, de Waal Malefyt R, Sleiman, PM, Hakonarson H, Cianferoni A, Falk GW, Wang ML, Spergel JM, and Artis D.: TSLP-Elicited Basophil Responses Can Mediate the Pathogenesis of Eosinophilic Esophagitis. Nature Medicine 19(8): 1005-13, 2013.

Jyonouchi S, Smith C, Saretta F, Abraham V, Ruymann K, Modayur PC, Wang ML, Spergel JM, and Cianferoni A.: Invariant Natural Killer T Cells in Children with Eosinophilic Esophagitis. Clinical Exp Allergy In press 2013.

Muir AB, Lim DM, Benitez AJ, Chandramouleeswaran PM, Lee AJ, Ruchelli ED, Spergel JM, and Wang ML.: Esophageal Epithelial-Mesenchymal Cross-Talk Leads to Features of Epithelial to Mesenchymal Transition In Vitro. Experimental Cell Research 319(6): 850-9, Apr 2013 Notes: *Featured article in Global Medical Discovery [ISSN 1929-8536] October, 2013.

2012

Spergel JM, Brown-Whitehorn TF, Cianferoni A, Shuker M, Wang ML, Verma R, and Liacouras CA: Identification of Causative Foods in Children with Eosinophilic Esophagitis Treated with an Elimination Diet. Journal of Allergy and Clinical Immunology 130(2): 461-7, August 2012.

2011

Lim DM and Wang ML: Toll-Like Receptor 3 Signaling Enables Human Esophageal Epithelial Cells to Sense Endogenous Danger Signals Released by Necrotic Cells. American Journal of Physiology: Gastrointestinal & Liver Physiology 301(1): G91-9, July 2011.

2010

Tetreault MP, Wang ML, Yang Y, Travis J, Yu QC, Klein-Szanto AJ, and Katz JP.: Klf4 Overexpression Activates Epithelial Cytokines and Inflammation-Mediated Esophageal Squamous Cell Cancer in Mice. Gastroenterology 139(6): 2124-2134, December 2010.

2009

Lim DM, Narasimhan S, Michaylira CZ, Wang ML. TLR3-mediated NF-{kappa}B signaling in human esophageal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2009 Dec; 297(6):G1172-80. Epub 2009 Sep 24. Read the abstract

Posters and Presentations

2014

"How to Choose a Research Project." 
First-year Fellow's Conference, 
North American Society for Gastroenterology, Hepatology, and Nutrition. 
Ft. Lauderdale, FL

2013

"Look who's talking: Esophageal epithelial cells as effector cells in eosinophilic esophagitis" - Research Seminar Series, Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI.

"Eosinophilic Esophagitis: Recent Advances and Challenges for the Basic Scientist." 11th Annual Eos Connections Patient Education Conference, American Partnership For Eosinophilic Disorders. Philadelphia, PA

2012

"Translational Models of Eosinophilic Esophagitis" - Research Seminar Series, Division of Gastroenterology, Hepatology, and Nutrition, Hospital for Sick Children, Toronto, Canada.

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