John H. Wolfe, VMD, PhD

2022

Ripolles-Garcia, A., Dolgova, N., Phillips, M.J., Savina, S., Ludwig, A.L., Stuedemann, S.A., Nlebedum, U., Wolfe, J.H., Garden, O., Gamm, D.M., Aguirre, G.D., Beltran, W.A.  (2022) Systemic immunosuppression promotes survival and integration of subretinally-implanted human ESC-derived photoreceptor precursors in dogs.  Stem Cell Reports, 17(8):1824-1841. 

Hunter JE, Molony CM, Bagel JH, O’Donnell PA, Kaler SG, Wolfe JH. (2022) Transduction characteristics of alternative adeno-associated virus serotypes in the cat brain by intracisternal delivery.  Mol. Ther. Meth. & Clin. Devel., 26: 384-393. 

2020

Yoon, S.Y., Hunter, J.E., Chawla, S., Clarke, D.L., Molony, C., O'Donnell, P., Bagel, J.H., Kumar, M., Poptani, H., Vite, C.H. and Wolfe, J.H. (2020) Global central nervous system correction in large brain model of human alpha-mannosidosis by intravascular gene therapy.  Brain, 143: 2058-2072.

2017

Mor, D.E., Tsika, E., Mazzulli, J.R., Gould, N.S., Kim, H., Daniels, M.J., Doshi, S., Gupta, P., Grossman, J.L., Tan, V.X., Kalb, R.G., Caldwell, K.A., Caldwell, G.A., Wolfe, J.H. and Ischiropoulos, H.  (2017) Dopamine-induced nigrostriatal degeneration is mediated by soluble α-synuclein oligomers.  Nature Neurosci. 20(11): 1560-1568.

2016

Parente, M.K., Rozen, R., Seeholzer, S.H. and Wolfe, J.H. (2016) Integrated analysis of proteome and transcriptome changes in the mucopolysaccharidosis type VII mouse hippocampus.  Mol Genet Metab. 118(1): 41-54.  PMCID: PMC4832927.

Yoon, S.Y., Bagel, J.H., O'Donnell, P.A., Vite, C.H. and Wolfe, J.H. (2016) Clinical improvement of alpha-mannosidosis cat following a single cisterna magna infusion of AAV1.  Mol. Ther., 24: 26-33.  

Kumar, M., Duda, J.T., Yoon, S.Y., Bagel, J., O'Donnell, P., Vite, C., Pickup, S., Gee, J., Wolfe, J.H. and Poptani, H. (2016) Diffusion tensor imaging for assessing gray and white matter abnormalities in a feline model of alpha-mannosidosis. J. Neuropath. Exp. Neurol., 75(1): 35-43. 

2015

Griffin, T.A, Anderson, H.C. and Wolfe, J.H. (2015) Ex vivo gene therapy using patient iPSC-derived NSCs reverses pathology in the brain of a homologous mouse model. Stem Cell Reports, 4: 835-46.

2013

Weerakkody, T.N., Patel, T.P., Yue, C., Takano, H., Anderson, H.C., Meaney, D.F., Coulter, D.A. and Wolfe, J.H.  (2013)  Engraftment of exogenous undifferentiated neural stem cells disrupts cortical network activity. Mol. Ther., 21: 2258-2267.

Simonato, M., Bennett, J., Boulis, N.M., Castro, M.G., Fink, D.J., Gray, S.J., Lowenstein, P.R., Vandenberghe, L.H., Wilson, T.J.,  Wolfe, J.H. and Glorioso, J.C. (2013)  Progress in gene therapy for neurological disorders.  Nature Rev. Neurol., 9: 277-291.

2010

Magnitsky, S., Vite, C.H., Delikatny, E.J., Pickup, S., Wehrli, S., Wolfe, J.H. and Poptani, P.  (2010) Magnetic resonance spectroscopy of the occipital cortex and cerebellar vermis distinguishes individual cats affected with alpha-mannosidosis from normal cats.  NMR Biomed. 23: 74-79. PMCID: PMC3045771.

2008

Cearley, C.N., Vandenberghe, L.H., Parente, M.K., Carnish, E.R., Wilson, J.M. and Wolfe, J.H.  (2008) Expanded repertoire of AAV vector serotypes mediate unique patterns of transduction in mouse brain. Mol. Ther., 16: 1710-1718.

Vite, C.H., Magnitsky, S., Aleman, D., O’Donnell, P., Cullen, K., Ding, W., Pickup, S., Wolfe, J.H. and Poptani, H.  (2008) Apparent diffusion coefficient reveals gray and white matter disease and T2 mapping detects white matter disease in the brain in feline alpha-mannosidosis.  Am. J. Neuroradiol., 29: 308-313. 

Walton R.M., Magnitsky, S.G., Seiler, G.S., Poptani, H. and Wolfe, J.H.  (2008) Transplantation and magnetic resonance imaging of canine neural progenitor cell grafts in the postnatal dog brain.  J. Neuropath. Exptl. Neurol., 67: 954-962. 

2007

Cearley, C.N. and Wolfe, J.H.  (2007)  A single injection of an AAV vector into nuclei with divergent connections results in widespread vector distribution and global correction of a neurogenetic disease.   J. Neurosci. 27: 9928-9940.

Walton, R.M. and Wolfe, J.H.  (2007)  Abnormalities in neural progenitor cells in a dog model of lysosomal storage disease.  J. Neuropath. Exp. Neurol. 66: 760-769.

2006

Cearley, C.N. and Wolfe, J.H.  (2006) Transduction characteristics of adeno-associated virus vectors expressing cap serotypes 7, 8, 9, and Rh10 in the mouse brain.  Mol. Ther., 13: 528-537.

2005

Vite, C.H., Niogi, S.N., McGowan, J.C., Passini, M.A., Drobatz, K.J., Haskins, M.E. and Wolfe, J.H.  (2005)  Effective gene therapy for an inherited diffuse CNS disease in a large animal model.  Ann. Neurol., 57: 355-364.

2003

Passini, M.A., Watson, D.J., Vite, C.H., Landsburg, D.J., Feigenbaum, A.L. and Wolfe, J.H.  (2003)  Intraventricular injection of AAV1 in neonatal mice results in complementary patterns of neuronal transduction to AAV2 and total long-term correction of storage lesions in the brains of ß glucuronidase-deficient mice.  J. Virol., 77: 7034-7040. 

Vite, C.H., Passini, M., Haskins, M.E. and Wolfe, J.H.  (2003)  Adeno-associated virus vector mediated transduction in the cat brain.  Gene Ther., 10: 1874-1881. 

2002

Heuer, G.G., Passini, M.A., Jiang, K., Parente, M.K., Lee, V.M.-Y., Trojanowski, J.Q. and Wolfe, J.H.  (2002) Selective neurodegeneration in murine mucopolysaccharidosis VII is progressive and reversible.  Ann. Neurol., 52: 762-770.

Passini, M.A., Lee, E.B., Heuer, G.G. and Wolfe, J.H.  (2002). Distribution of a lysosomal enzyme in the adult brain by axonal transport and by cells of the rostral migratory stream. J. Neuroscience, 22: 6437-6446. 

Watson, D.J., Kobinger, G., Passini, M.A., Wilson, J.M. and Wolfe, J.H.  (2002) Targeted transduction patterns in the mouse central nervous system by lentivirus vectors pseudotyped with envelope proteins  from Vesicular Stomatitis virus, Ebola virus, Mokola virus, Lymphocytic Choriomeningitis virus or Murine Leukemia virus.  Mol. Ther., 5: 528-537.

Ponder, K.P., Melniczek, J.R., Xu, L., Weil, M.A., O'Malley, T.M., O'Donnell, P.A., Knox, V.W., Aguirre, G.D., Mazrier, H., Ellinwood, N.M., Sleeper, M., Maguire, A.M., Volk, S.W., Mango, R.L., Zweigle, J., Wolfe, J.H. and Haskins, M.E.  (2002)  Marked clinical improvements in mucopolysaccharidosis VII dogs after neonatal  administration of a retroviral vector expressing ß-glucuronidase.  Proc. Natl. Acad. Sci. U.S.A., 99:13102-13107.

1997

Taylor, R.M. and Wolfe, J.H.  (1997) Decreased lysosomal storage in the adult MPS VII mouse brain in the vicinity of grafts of retroviral vector-corrected fibroblasts secreting high levels of ß-glucuronidase.  Nature Medicine  3: 771-774.

1995

Snyder, E.Y., Taylor, R.M. and Wolfe, J.H.  (1995)  Neural progenitor cell engraftment corrects lysosomal storage throughout the MPS VII mouse brain.  Nature, 374: 367-370.

1992

Wolfe, J.H., Sands, M.S., Barker, J.E., Rowe, L.B., Gwynn, B., Vogler, C.A., and Birkenmeier, E.H.  (1992)  Reversal of pathology in murine mucopolysaccharidosis type VII by somatic cell gene transfer.  Nature 360: 749-753.

Wolfe, J.H., Deshmane, S.L. and Fraser, N.W. (1992).  Herpesvirus vector gene transfer and expression of ß-glucuronidase in the CNS of MPS VII mice.  Nature Genetics 1:379-384.

1990

Wolfe, J.H., Schuchman, E.H., Stramm, L.E., Concaugh, E.A., Haskins, M.E., Aguirre, G.D., Patterson, D.F., Desnick, R.J. and Gilboa, E. (1990).  Restoration of normal function in mucopolysaccharidosis type VII cells by gene transfer.  Proc. Natl. Acad. Sci. U.S.A., 87: 2877-2881.