Diabetes insipidus is a condition that results from insufficient production of the antidiuretic hormone (ADH), a hormone that helps the kidneys and body conserve the correct amount of water. Normally, the antidiuretic hormone controls the kidneys' output of urine. It is secreted by the hypothalamus (a small gland located at the base of the brain) and stored in the pituitary gland and then released into the bloodstream. ADH is secreted to decrease the amount of urine output so that dehydration does not occur. Diabetes insipidus, however, causes excessive production of very diluted urine and excessive thirst. The disease is categorized into groups:
Diabetes insipidus can be caused by several conditions, including the following:
The following are the most common symptoms of diabetes insipidus. However, each child may experience symptoms differently. Symptoms may include:
Infants with diabetes insipidus may also exhibit the following symptoms:
The symptoms of diabetes insipidus may resemble other problems or medical conditions. Always consult your child's physician for a diagnosis.
In addition to a complete medical history and physical examination, including the child's daily fluid intake, dietary intake, and voiding (bowel and bladder elimination) patterns, diagnostic procedures for diabetes insipidus may include:
If left untreated in children, diabetes insipidus can lead to brain damage, impaired mental function, mental retardation, hyperactivity, short attention span, and/or restlessness. Treatment for diabetes insipidus depends on what is causing the disease. Treating the cause usually treats the diabetes insipidus. Specific treatment for diabetes insipidus will be determined by your child's physician based on:
Treatment may include modified antidiuretic hormone medications (often taken as a nasal spray), or medications that stimulate the production of the antidiuretic hormone. In addition, persons with diabetes insipidus must maintain adequate fluid intake to compensate for the excessive urinary output, and eat a low-sodium diet. Although children with the disease also need to drink plenty of fluids, care should be taken to monitor sodium intake in their fluids.
Diabetes insipidus can be a temporary or a permanent condition, depending on what is causing the disease. Children with central diabetes insipidus, with proper management, can lead full, healthy lives. Children with nephrogenic diabetes insipidus, can also lead relatively normal lives with proper medical care and management, especially if the medical care is started early.