Complicated Twin Pregnancies Publications

The following list of publications will help you in your search for more information about complicated twin pregnancies, including stuck twins, twin reversed arterial perfusion (TRAP) sequence, twin-twin transfusion syndrome (TTTS) and conjoined twins. Most are written by members of the Fetal Diagnosis and Treatment team at The Children's Hospital of Philadelphia. If you are unable to obtain any of these publications, please let us know, and we will send copies to you.

Journal articles


Vrecenak JD, Howell LJ, Khalek N, Moldenhauer JS, Johnson MP, Coleman BG, Victoria T, Hedrick HL, Peranteau WH, Flake AW, Adzick NS. Outcomes of Prenatally Diagnosed Lung Lesions in Multigestational Pregnancies. Fetal Diagn Ther. 2014. Epub 2014 Nov 5. Read the abstract.


Oliver ER, Coleman BG, Goff DA, Horii SC, Howell LJ, Rychik J, Bebbington MW, Johnson MP. Twin reversed arterial perfusion sequence: a new method of parabiotic twin mass estimation correlated with pump twin compromise. J Ultrasound Med. 2013 Dec;32(12):2115-23. doi: 10.7863/ultra.32.12.2115. Read the abstract.


Bebbington MW, Danzer E, Moldenhauer J, Khalek N, Johnson MP. Radio frequency ablation vs. bipolar umbilical cord coagulation in the management of complex monochorionic pregnancies. Ultrasound Obstet Gynecol. 2012 Feb 3. doi: 10.1002/uog.11122. [Epub ahead of print]. Cited in PubMed; PMID 22302774. Read the abstract.


Skupski DW, Luks FI, Walker M, Papanna R, Bebbington M, Ryan G, et al. Preoperative predictors of death in twin-to-twin transfusion syndrome treated with laser ablation of placental anastomoses. Am J Obstet Gynecol. 2010 Oct;203(4):388.e1-388.e11. Epub 2010 Aug 9. Cited in PubMed; PMID 20691964. Read the abstract.

Bebbington M, Tiblad E, Huesler-Charles M, Wilson R, Mann S, Johnson M. Outcomes in a cohort of patients with stage 1 twin-to-twin transfusion syndrome (TTTS). Ultrasound Obstet Gynecol. 2010 July; 36(1): 48-51. [Epub ahead of print] Read the abstract.


Wilson RD, Johnson A, Ryan G. Current controversies in prenatal diagnosis 2: Should laser ablation of placental anastomoses be used in all cases of twin to twin transfusion?  Prenat Diagn. 2009 Jan;29(1):6-10. No abstract available

Bebbington M. Twin-to-twin transfusion syndrome: Current understanding of pathophysiology, in-utero therapy and impact for future development. Semin Fetal Neonatal Med. 2009 Jun 16. Cited in PubMed; PMID 19539549.


Illagan JG, Wilson RD, Bebbington MW, Johnson MP, Hedrick HL, Kiechty KW, et al. Pregnancy outcomes following bipolar umbilical cord cauterization for selective termination in complicated monochorionic multiple gestations. Fetal Diag and Therapy 2008; 23:153-158. Cited in PubMed; PMID 18042995.


Delisle MF, Brosseuk L, Wilson RD. Amniocentesis for twin pregnancies: Is alpha-fetoprotein useful in confirming that the two sacs were sampled? Fetal Diag and Therapy 2007;22: 221-225. Cited in PubMed; PMID 17228163.

Rychik J, Tian Z, Bebbington M, Xu F, McCann M, Mann S, et al.  The twin-twin transfusion syndrome: Spectrum of cardiovascular abnormality and development of a cardiovascular score to assess severity of disease. Am J Obstet Gynecol 2007: 197:392f.e1-392.e8. Cited in PubMed; PMID 17904973.

Crombleholme TM, Shera D, Lee H, Johnson MP, D'Alson M, Porter F, et al. A prospective, randomized, multicenter trial of amnioreduction vs selective fetoscopic laser photocoagulation for the treatment of severe twin-twin transfusion syndrome. Am J Obstet Gynecol 2007; 197:396.e1-369.e9. Cited in PubMed; PMID 17904975.


von Dadelszen P, Kives S, Delisle MF, Wilson RD, Joy R, et al. The association between early membrane rupture, latency, clinical chorioamnionitis, neonatal infection, and adverse perinatal outcomes in twin pregnancies complicated by preterm prelabour rupture of membranes. Twin Research, Vol 6(4):257-262, August 2003. Cited in PubMed; PMID 14511428.


MacKenzie TC, Crombleholme TM, Johnson MP, Schnaufer L, Flake AW, Hedrick HL, et al. The natural history of prenatally diagnosed conjoined twins. Journal of Pediatric Surgery 37:303-309, 2002. Cited in PubMed; PMID 11877639.


DeLia JE, Kuhlman RS, Clark SA: Fetoscopic laser treatment of twin-twin transfusion syndrome: Expectations and results post learning curve. Fetal Diagn Ther, 13(5), 1998.


Ville Y, Hyett K, et al: Preliminary experience with endoscopic laser surgery for severe twin-twin transfusion syndrome. N Engl J Med, 332:224-227, 1995.

Reviewed on December 31, 2013