Plastic and Reconstructive Surgery Research

Our multidisciplinary team of physicians focuses not only on providing the best possible care for our patients, but also on research that will improve treatment and quality of life for the children we treat.

The Division of Plastic and Reconstructive Surgery at CHOP has been a leader in pediatric plastic surgery research for decades. In addition, we benefit from the close proximity of the research lab of the University of Pennsylvania’s Division of Plastic Surgery, located at the Leonard and Madlyn Abramson Pediatric Research Center at The Children’s Hospital of Philadelphia.

Clinical outcomes research

Clinical outcomes research involves long-term results of surgical therapy, innovative treatment with novel devices and techniques, and psychological outcomes of surgery in children with facial and body differences. Current research includes:

  • Chromosome 22q11.2 deletion syndrome: palatal phenotypes and surgical outcomes. (Plastic and Reconstructive Surgery team physicians)
  • Clinical outcomes in cleft lip and palate surgery. (Plastic and Reconstructive Surgery team physicians)

Basic science research

Our basic research laboratory investigates disease mechanisms and treatment for a variety of congenital disorders, including:

  • Biocompatibility, osteoconductivity, and remodeling capacity of Norian CRS bone cement in the immature craniofacial skeleton (Scott P. Bartlett, MD)
  • Effects of intrauterine constraint on craniofacial development
  • Effects of biomechanical force on the dura mater and calvarial bone
  • Influence of TGF-beta isoforms on dural and calvarial bone cell growth and differentiation
  • Pediatric craniofacial reconstruction using Norian CRS: Influence on craniofacial growth (Scott P. Bartlett, MD)
  • Synthetic hybrid grafts for gene therapy in craniofacial reconstruction
  • Synthetic hybrid grafts for gene therapy in chronic wound healing (Timothy Crombleholme, MD)

Reviewed on December 31, 2013