|2 months - < 12 months
≥ 12 months + NO Ceftriaxone within past 8 weeks
≥ 12 months + Ceftriaxone within past 8 weeks
|Acute Chest Syndrome (ACS)||Ampicillin + Azithromycin|
Concern for meningitis/sepsis
|Cefotaxime + Vancomycin|
30 minutes following Ceftriaxone administration, monitor for signs
If history of anaphylaxis to penicillin or any Cephalosporin reaction, give Clindamycin.
Severe hemolytic reactions to ceftriaxone have been reported in patients with SCD. It is postulated that this may be an immune-mediated reaction related to recent ceftriaxone exposure.