In the initial reports of Alagille syndrome, mental retardation was described as being a common feature. More recent studies have demonstrated mild delays in gross motor skills in 16 percent of patients and mild mental retardation in very few. The decreased prevalence of learning disabilities in recent studies most likely represents earlier disease recognition and more aggressive medical and nutritional intervention, particularly vitamin supplementation. If your child is suspected of having a developmental delay, he or she may be referred to a developmental pediatrician for evaluation.
Reviewed by: Binita M. Kamath, MD
Date: January 2009