- CHOP Home
- Specialties and Services
- Cardiac Center
- Cardiac Center Research
- Genetic Roots of Heart Disease
Cardiac Center
- Cardiac Center
- Congenital Heart Defect Awareness
- About the Cardiac Center
- Meet Our Team
- Our Services
- Cardiology
- Cardiothoracic Surgery
- Cardiothoracic Anesthesia
- Cardiac Nursing
- Diagnosis and Testing
- Familial Cardiomyopathy Program
- Fetal Heart Program
- Heart Failure and Heart-Lung Transplantation
- Infant Single Ventricle Monitoring Program
- Lipid Heart Clinic
- NeuroCardiac Care Program
- Nurse Navigators
- Pediatric Heart Transplantation
- Philadelphia Adult Congenital Heart Center
- Single Ventricle Survivorship Program
- Offsite PDA Ligation
- Support for Families
- Youth Heart Watch
- Heart Conditions
- How the Normal Heart Works
- Symptoms that Might Indicate a Heart Problem
- Anomalous Left Coronary Artery From the Pulmonary Artery (ALCAPA)
- Aortic Regurgitation
- Aortic Stenosis
- Atrial Septal Defect (ASD)
- Atrioventricular Canal Defects
- Cardiomyopathy
- Chest Pain in Children and Teenagers
- Coarctation of the Aorta
- Congenitally Corrected Transposition of the Great Arteries (CCTGA)
- Double Outlet Right Ventricle
- Ebstein’s Anomaly of the Tricuspid Valve
- Heart Block
- Heart Murmur
- Heart Tumors
- Heterotaxy Syndrome (Isomerism)
- Hypoplastic Left Heart Syndrome
- Interruption of the Aortic Arch
- Kawasaki Disease
- Long QT Syndrome
- Mitral Stenosis, Mitral Regurgitation and Mitral Valve Prolapse
- Myocarditis
- Palpitations
- Patent Ductus Arteriosus (PDA)
- Pulmonary Atresia
- Pulmonary Hypertension
- Pulmonary Regurgitation
- Pulmonary Stenosis
- Rheumatic Fever and Rheumatic Heart Disease
- Single Ventricle
- Supraventricular Tachycardia (SVT)
- Syncope (Fainting)
- Tetralogy of Fallot
- Total Anomalous Pulmonary Venous Return (TAPVR)
- Transposition of the Great Arteries
- Tricuspid Atresia
- Truncus Arteriosus
- Vascular Ring
- Ventricular Septal Defect (VSD)
- Cardiac Center Outcomes
- Cardiac Center Research
- Better Valves, Better Lives
- Brain Injury in Newborns With CHD
- Effects of Stress Caused by Prenatal Diagnoses
- Genetic Roots of Heart Disease
- Heart Valve Disease
- Home Care After Cardiac Surgery in Infants With CHD
- Improving Blood Flow after HLHS Surgery
- Neurodevelopmental Problems in Children With CHD
- Psychological Impact of Prenatal Diagnosis of CHD
- Underlying Causes of Heart Defects
- Understanding the Cause of Ischemia in AAOCA
- Locations and Facilities
- Patient Stories
- Anomalous Left Coronary Artery From Pulmonary Artery -- Quinn
- Aortic Stenosis -- Sarah
- Aortic and Pulmonary Stenosis -- Matthew
- Atrial Septal Defect -- Morgan
- Atrial Septal Defect -- Ryan
- Double Inlet Left Ventricle -- Abby
- Cardiomyopathy -- Julia
- Heart Block -- Brie
- Hypoplastic Left Heart Syndrome -- Tassos
- Hypoplastic Left Heart Syndrome -- Caila
- Hypoplastic Left Heart Syndrome -- Lily
- Hypoplastic Left Heart Syndrome - Xavier
- Hypoplastic Left Heart Syndrome - Maya
- Hypoplastic Left Heart Syndrome – Zoe & Kellen
- Kawasaki Disease and Heart Transplant -- Kendall
- Patent Ductus Arteriosus -- Katie
- Pulmonary Atresia -- Justin
- Single Ventricle -- Brendan
- Supraventricular Tachycardia -- Oliver's Story
- Tetralogy of Fallot -- Aidan
- Tetralogy of Fallot - Ben
- Tetralogy of Fallot -- Brittany
- Tetralogy of Fallot -- Marla
- Tetralogy of Fallot -- Matthew
- Transposition of the Great Arteries -- Brandon
- Transposition of the Great Arteries -- Chase
- Transposition of the Great Arteries -- Ian
- Transposition of the Great Arteries -- Joanna
- Transposition of the Great Arteries and VSD -- Melissa
- Transposition of the Great Arteries -- Max
- Ventricular Septal Defect -- Nora
- Tricuspid Atresia -- Srishti
- Videos
- Resources for Families
- Resources for Healthcare Professionals
- In the News
- Ways to Give
- Careers at the Cardiac Center
- Contact Us / Families
- Contact Us / Healthcare Professionals
- Glossary
The Genetic Roots of Heart Disease
Although congenital heart disease represents the most common major birth defect, scientists have not previously identified the common variation in the genes that give rise to it. Now genetics and cardiology researchers, two of them brothers, have discovered a genetic variant on chromosome 5 that strongly raises the risk of congenital heart disease. The study appeared online today in the journal Public Library of Science One.
Watch a video of Peter J. Gruber, MD, PhD, discussing his breakthrough study»
Contact Us
For a second opinion, cardiac referral, or for more information.
267-426-9600
To schedule an outpatient appointment.
215-590-4040
Get Driving Directions
Awards and Honors
Legal
Short Cuts
- Cancer Center
- Cardiac Center
- Fetal Diagnosis and Treatment
- Pediatric Blood and Marrow Transplantation Program
- Site Map
- Our Philosophy of Care
- Directions, Maps and Parking
- Hospital Virtual Tour
- Guide to Your Child's Surgery
- Your Child's Bill
- Sign Up for Newsletters
- Social Media at CHOP
- Physician Referral Services
- Fellowships at The Children's Hospital of Philadelphia
- Continuing Medical Education
- © 1996-2013 The Children's Hospital of Philadelphia
34th Street and Civic Center Boulevard
Philadelphia, Pa. 19104 - Main Number: 215-590-1000
- Physician Referral Service: 1-800-879-2467
- Coordinates: 39.9486937, -75.1929596
- An Equal Opportunity Employer
- The Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, sexual orientation, age, religion, national or ethnic origin, disability or veteran status.