Congenital Hyperinsulinism Center

Congenital Hyperinsulinism Research Studies

Outcomes in children with hyperinsulinism research study

Although complications of hyperinsulinism during the first year of life are well documented, less is known about complications from hyperinsulinism later in life. Children with HI are at risk of developmental and behavioral problems, such as learning disabilities and attention deficit disorder. In addition, children who undergo surgery on their pancreas have higher rates of diabetes. Few studies have been done which have examined these long-term complications in children with HI.

Diva De Leo ́n-Crutchlow, MD, and Katherine Lord, MD, are conducting a study to determine the long-term outcomes in children with hyperinsulinism who were treated at The Children’s Hospital of Philadelphia. The goal of the study is to determine how many children with hyperinsulinism develop diabetes and developmental or behavioral problems.

From the study, researchers hope to better understand the long-term risks associated with hyperinsulinism and its treatments. This knowledge may lead to improved screening for these complications and earlier interventions if they are found.

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FDA and NIH Grants

Dr. Diva De Leon-Crutchlow has been awarded two grants to continue her breakthrough research in the treatment of HI:

  • An FDA grant totaling about $759,000 over 3 years for the Phase 2A Study of Exendin for the Treatment of Congenital Hyperinsulinism. FDA Press Annoucement»
  • An NIH grant totaling about $1,800,000 over 5 years to study the pathophysiology of hyperinsulinism. NIH Project information»