CHOP scarless fetal wound healing publications | The Children's Hospital of Philadelphia

Center for Fetal Diagnosis and Treatment

Scarless Fetal Wound Healing Publications

The following list of fetal treatment and fetal surgery publications will help you in your search for more information. Most are written by members of the Fetal Diagnosis and Treatment team at The Children's Hospital of Philadelphia. The articles are organized into general and diagnosis-specific categories. If you are unable to obtain any of these publications, please let us know and we will send copies to you.

Journal articles

2008

Ricchetti  ET, Reddy SC, Ansorge HL, Zgonis MH, Van Kleunen JP, Liechty KW, Soslowsky LJ, Beredjiklian PK. Effect of interleukin-10 overexpression on the properties of healing tendon in a murine patellar tendon model. J Hand Surg Am. 2008 Dec;33(10):1843-52. 

Badillo AT, Zhang L, Liechty KW. Stromal progenitor cells promote leukocyte migration through production of stromal-derived growth factor 1alpha: a potential mechanism for stromal progenitor cell-mediated enhancement of cellular recruitment to wounds.  J Pediatr Surg. 2008 Jun;43(6):1128-33.

2007

Badillo AT, Redden RA, Zhang L, Doolin EJ, Liechty KW. Treatment of diabetic wounds with fetal murine mesenchymal stromal cells enhances wound closure. Cell Tissue Res. 2007 Aug;329(2):301-11. Epub 2007 Apr 24.

1998

Namba R, Meuli M, Sullivan KM, Le A, Adzick NS: The spontaneous repair of superficial articular cartilage defects in a fetal lamb model. J Bone Joint Surg 80-A 1: 4-10, 1998.

1997

Cass DL, Meuli M, Adzick NS: Scar Wars: Implications of fetal wound healing for the pediatric burn patient. Pediatr Surg International 12:484-489, 1997.

Stelnicki EJ, Komuves LG, Holmes, Clavin W, Harrison MR, Adzick NS, Largman C: The human homeobox genes MSX-1, MSX-2, and MOX-1 are differentially expressed in the dermis and epidermis in fetal and adult skin. Differentiation 62:33-41, 1997.

Stelnicki EJ, Komuves LG, Kwong AO, Holmes D, Klein P, Rozenfeld S, Lawrence HJ, Adzick NS, Harrison MR, Largman C: HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development. J Invest Dermatol. 1998 Feb;110(2):110-5.

Lovvorn HN, Cass DL, Sylvester KG, Crombleholme TM, Adzick NS, Savani RC: Hyaluronan receptor expression increases in fetal excisional skin wounds and correlates with fibroplasia. J Pediatr Surg. 1998 Jul;33(7):1062-9; discussion 1069-70.

Stelnicki EJ, Bullard KM, Harrison MR, Cass DL, Adzick NS: A new in vivo model for the study of fetal wound healing. Ann Plast Surg 39: 374-380, 1997.

Liechty KW, Crombleholme TM, Sylvester KG, Lovvorn HN, Kitano Y, Cass DL, Adzick NS: Differential IL-6 production by fetal vs. adult fibroblasts. Surgical Forum 47: 707-709, 1997.

Lovvorn HN, Cheung DT, Nimni ME, Perelman N, Estes JM, Adzick NS: Deposition and crosslinking of collagen during fetal and adult sheep wound repair. J Pediatr Surg. 1999 Jan;34(1):218-23.

Cass DL, Bullard KM, Sylvester KG, Yang EY, Longaker MT, Adzick NS: Wound size and gestational age modulate scar formation in fetal wound repair. J Pediatr Surg 32:411-415, 1997.

Bullard KM, Cass DL, Banda MJ, Adzick NS: TGF-beta1 decreases collagenase in healing human fetal skin. J Pediatr Surg 32:1023-1027, 1997.

Cass DL, Sylvester KG, Yang EY, Crombleholme TM, Adzick NS: Myofibroblast persistence in fetal sheep wounds is associated with scar formation. J Pediatr Surg 32:1017-1022, 1997.

West DC, Shaw DM, Lorenz P, Adzick NS, Longaker MT: Fibrotic healing of adult and late gestation fetal wounds correlates with increased hyaluronidase activity and removal of hyaluronan. Int J Biochem Cell Biol 29: 201-210, 1997.

1996

Cass DL, Bullard KM, Sylvester KG, Yang EY, Sheppard D, Herlyn M, Adzick NS: Epithelial integrin expression is rapidly upregulated in human fetal wound repair. Surgical Forum 47:765-767, 1996.

Hedrick MH, Rice HE, Vanderwall KJ, Adzick NS, Harrison MR, Siebert J, Hoffman WY, Bullard KM, Cass DL, Banda MJ, Adzick NS: TGF-beta1 decreases collagenase in healing human fetal skin. Surgical Forum 47:762-765, 1996.

Cass DL, Bullard KM, Sylvester KG, Yang EY, Sheppard D, Herlyn M, Adzick NS: Epithelial integrin expression is rapidly upregulated in human fetal wound repair. Surgical Forum 47:765-767, 1996.

Gallo R, Kim C, Kokenyesi R, Adzick NS, Bernfield M: Syndecans-1 and -4 are locally and distinctly induced during wound repair of neonatal but not fetal skin. J Invest Derm 107:676-683, 1996.

Lin RY, Adzick NS: The role of the fetal fibroblast and transforming growth factor beta in a model of human fetal wound repair. Seminars Ped Surg 5:165-174, 1996.

1995

Sullivan KM, Lorenz HP, Adzick NS: A model of human fetal skin repair is deficient in transforming growth factor beta. J Pediatr Surg 30:198-203, 1995.

Meuli M, Lorenz HP, Hedrick MH, Sullivan KM, Harrison MR, Adzick NS: Scar formation in the fetal alimentary tract. J Pediatr Surg 30:392-395, 1995.

Sullivan KM, MacGillivray TE, Meuli M, Adzick NS: An adult-fetal skin interface heals without scar formation in sheep. Surgery 118:82-86, 1995.

Lin RY, Sullivan KM, Argenta PA, Lorenz HP, Adzick NS: Exogenous transforming growth factor beta amplifies its own expression and induces scar formation in a model of human fetal skin repair. Ann Surg 222:146-154, 1995.

Lorenz HP, Lin RY, Longaker MT, Whitby DJ, Adzick NS: The fetal fibroblast: The effector cell for scarless fetal skin repair. Plast Reconstr Surg 96:1251-1261, 1995.

Siebert JW, Sung JJ, Zirn J, Kamino H, Hedrick MH, Adzick NS, Gold LI, Longaker MT: Immunohistochemical localization of transforming growth factor beta isoforms during fetal wound healing. Surgical Forum 46:646-648, 1995.

1994

Longaker MT, Whitby DJ, Ferguson MWJ, Harrison MR, Adzick NS: Adult skin in the fetal environment heals with scar formation. Ann Surg 219:65-72, 1994.

Estes JM, Vande Berg JS, Adzick NS, MacGillivray TE, Desmouliére A, Gabbiani G: Phenotypic and functional features of myofibroblasts in fetal wounds. Differentiation, 56:173-181,1994.

Adzick NS, Lorenz HP: Cells, matrix, growth factors, and the surgeon: The biology of scarless fetal wound repair. Ann Surg 220:10-18, 1994.

Lin RY, Sullivan KM, Argenta PA, Lorenz HP, Adzick NS: Scarless human fetal skin repair is intrinsic to the fetal fibroblast and occurs in the absence of an inflammatory response: In situ hybridization and immunohistochemical studies. Wound Repair and Regeneration 2:297-305, 1994.

Lin RY, Sullivan KM, Argenta PA, Lorenz HP, Adzick NS: Species-specific in situ hybridization demonstrates that the human fetal fibroblast modulates scarless repair. Surgical Forum 45:659-662, 1994.

West DC, Shaw DM, Lorenz HP, Adzick NS, Longaker MT: Hyaluronidase activity in fetal and adult wounds. Surgical Forum 45:753-754, 1994.

Sullivan KM, MacGillivray TE, Meuli M, Adzick NS: An adult-fetal skin interface heals without scar formation in sheep. Surgical Forum 45:662-664, 1994.

1993

Lorenz HP, Whitby DJ, Longaker MT, Adzick NS: Fetal wound healing: The ontogeny of scar formation in the non-human primate. Ann Surg 217:391-6, 1993.

Freund RM, Siebert JW, Cabrera J, Longaker MT, Eidelman Y, Adzick NS, Garg HG: Serial quantitation of hyaluronan and sulfated glycosaminoglycans in fetal sheep skin. Biochem Mol Biol Int 29:773-784, 1993.

Chang J, Longaker MT, Lorenz HP, Roberts AB, Harrison MR, Adzick NS, Banda MJ: Fetal and adult sheep fibroblast TGF-?1 gene expression in vitro: Effects of hypoxia and gestational age. Surg Forum 44:720-722, 1993.

Kaban LB, Dodson TB, Stern M, Umeda H, Longaker MT, Adzick NS: Fetal cleft lip repair in rabbits: Long-term clinical and cephalometric results. Cleft Palate Craniofacial J 30:12-18, 1993.

Estes JM, Adzick NS, Longaker MT, Harrison MR, Stern R: Hyaluronate metabolism undergoes ontogenetic transition during fetal development: Implications for scarless wound healing. J Pediatr Surg 28:1227-1231, 1993.

Lorenz HP, Adzick NS: Scarless skin wound repair in the fetus. West J Med 159:350-355, 1993.

Sullivan KM, Lorenz HP, Adzick NS: The role of transforming growth factor beta in human fetal wound healing. Surgical Forum 44:625-627, 1993.

Qian JJ, Duncan BW, Adzick NS, Bhatnagar RS: Regulation of prolyl hydroxylase by ascorbic acid is mediated by polyADP-ribose synthesis. Cellular and Molecular Biol Res 39:525-533, 1993.

1992

Longaker MT, Moelleken BRW, Cheng JC, Jennings RW, Gordon L, Adzick NS, Harrison MR, Simmons D: Fetal fracture healing in a lamb model. Plast Reconst Surg 90:161-171, 1992.

Longaker MT, Stern M, Lorenz HP, Whitby DJ, Harrison MR, Adzick NS, Kaban LB: A model for fetal cleft lip repair in lambs. Plast Reconstr Surg 90:750-6, 1992.

Lorenz HP, Longaker MT, Perchoka LA, Jennings RW, Harrison MR, Adzick NS: Scarless wound repair: A human fetal skin model. Development 114:253-259, 1992.

Duncan BW, Adzick NS, Moelleken BRW, Chua J, Bradley SM, Longaker MT, Levinsohn DG, Harrison MR, Kaban LB: An in utero model of craniosynostosis. J Craniofacial Surg 3:70-8, 1992.

Adzick NS and Longaker MT: Scarless fetal healing: Therapeutic implications. Ann Surg 215(1):3-6, 1992.

Lorenz HP, Adzick NS, Longaker MT, Stern R: Scarless fetal wound repair: A review. Advances in Plastic and Reconstructive Surgery 9:83-101, 1992.

Lorenz HP, Longaker MT, Whitby DJ, Harrison MR, Adzick NS: Scarless fetal skin repair is intrinsic to the fetal fibroblast. Surgical Forum 43:694-6, 1992.

1991

Longaker MT, Whitby DJ, Ferguson MWJ, Jennings RW, Lorenz HP, Harrison MR, Adzick NS: Adult skin in the fetal environment heals with scar formation. Plast Surg Forum 14:346-8, 1991.

Longaker MT, Bouhana KS, Roberts AB, Harrison MR, Adzick NS, Banda MJ: Regulation of fetal wound healing. Plast Surg Forum 14:296-297, 1991.

Adzick NS, Longaker MT: Scarless wound healing in the fetus: The role of the extracellular matrix. Prog Clin Biol Res 365:177-192, 1991.

Longaker MT, Adzick NS: The biology of fetal wound healing: A review. Plast Reconstr Surg 87:788-98, 1991.

Longaker MT, Chiu ES, Adzick NS, Stern M, Harrison MR, Stern R: Studies in fetal wound healing: V. A prolonged presence of hyaluronic acid characterizes fetal wound fluid. Ann Surg 213:292-296, 1991.

Burd DAR, Longaker MT, Rittenburg T, Adzick NS, Harrison MR, Ehrlich HP: In vitro fetal wound contraction: The effect of amniotic fluid. Br J Plast Surg 44:302-305, 1991.

Whitby DJ, Longaker MT, Adzick NS, Harrison MR, Ferguson MWJ: Rapid epithelialization of fetal wounds is associated with the early deposition of tenascin. J Cell Science 99:583-586, 1991.

Longaker MT, Whitby DJ, Adzick NS, Kaban LB, Harrison MR: Fetal surgery for cleft lip: A plea for caution. Plast Reconstr Surg 88:1087-1092, 1991.

Longaker MT, Adzick NS: The biology and therapeutic implications of fetal wound healing. Clinical Materials 8:223-227, 1991.

Estes JM, Spencer EM, Longaker MT, Adzick NS: Insulin-like growth factor-II in ovine wound fluid: Developmental regulation. Surgical Forum 42:659-661, 1991.

Longaker MT, Bouhana KS, Roberts AB, Harrison MR, Adzick NS, Banda MJ: Regulation of fetal wound healing. Surgical Forum 42:575-577, 1991.

Michaels BM, Piscatelli S, Siebert JW, Jennings RW, Longaker MT, Adzick NS: Amniotic fluid stimulates or inhibits fibroblasts, depending on gestational age. Surgical Forum 42:656-658, 1991.

Longaker MT, Whitby DJ, Jennings RW, Duncan BW, Ferguson MWJ, Harrison MR, Adzick NS: Fetal diaphragmatic wounds heal with scar formation. J Surg Res 50:375-85, 1991.

Longaker MT, Burd DAR, Gown AM, Yen TSB, Jennings RW, Duncan BW, Harrison MR, Adzick NS: Midgestational excisional fetal lamb wounds contract in utero. J Pediatr Surg 26:942-948, 1991.

Jennings RW, Adzick NS, Longaker MT, Duncan BW, Scheuenstuhl H, Hunt TK: Ontogeny of fetal sheep polymorphonuclear leukocyte phagocytosis. J Pediatr Surg 26:853-855, 1991.

Adzick NS, Longaker MT: Animal models for the study of fetal tissue repair. J Surg Res 51:216-222, 1991.

Rittenberg T, Longaker MT, Adzick NS, Ehrlich HP: Sheep amniotic fluid has a protein factor which stimulates human fibroblast populated collagen lattice contraction. J Cell Physiol 149:444-450, 1991.

Moelleken BRW, Longaker MT, Cheng JC, Jennings RW, Levinsohn DG, Gordon L, Adzick NS, Harrison MR, Simmons D: Fetal fracture healing in a large animal model. Surgical Forum 42:668-670, 1991.

1990

Burd DAR, Longaker MT, Adzick NS, Harrison MR, Ehrlich HP: Fetal wound healing in a large animal model: The deposition of collagen is confirmed. Brit J Plast Surg 43:571-577, 1990.

Longaker MT, Whitby DJ, Adzick NS, Crombleholme TM, Duncan BW, Stern R, Harrison MR: Studies in fetal wound healing VI. Second and early third trimester fetal wounds demonstrate rapid collagen deposition without scar formation. J Pediatr Surg 25:63-69, 1990.

Burd DAR, Longaker MT, Adzick NS, Harrison MR, Ehrlich HP: Fetal wound healing: An in vitro explant model. J Pediatr Surg 25:898-901, 1990.

Longaker MT, Whitby DJ, Jennings RW, Duncan BW, Harrison MR, Ferguson MWJ, Adzick NS: Adult skin in the fetal environment heals with scar formation. Surgical Forum 41:639-41, 1990.

Chiu ES, Longaker MT, Adzick NS, Stern M, Harrison MR, Stern R: Hyaluronic acid patterns in fetal and adult wound fluid. Surgical Forum 41:636-639, 1990.

1989

Longaker MT, Chiu ES, Harrison MR, Crombleholme TM, Duncan BW, Adzick NS, Stern R: Studies in fetal wound healing IV. Hyaluronic acid stimulating activity distinguishes fetal from adult wound fluid.Annals of Surgery 210:667-672, 1989.

Duncan BW, Adzick NS, Bradley SM, Longaker MT, Levinsohn DG, Moelleken BR, Harrison MR, Kaban LB: An in utero model of craniosynostosis. Surg Forum 40:608-609, 1989.

1985

Adzick NS, Harrison MR, Glick PL, Beckstead JH, Villa RL, Scheuenstuhl H, Goodson WH III: Comparison of fetal, newborn, and adult rabbit wound healing by histologic, enzyme-histochemical, and hydroxyproline determinations. J Pediatr Surg 20:315-319, 1985.

Books

Adzick NS, Longaker, MT. Fetal Wound Healing. Elsevier Science Publishing Co., Inc., NY 1992

Chapters

Cass DL, Adzick NS: Fetal wound healing implications. In Katowitz JA (ed): Pediatric Oculoplastic Surgery. Springer, pp.31-42, 2002.

Krupnick A, Adzick NS: Wound healing. The Surgical Review: An Integrated Basic and Clinical Science Study Guide, Kreisel D, Krupnick AS, Kaiser LR (eds) Lippincott-Raven, pp 110-122, 2001.

Krupnick A, Adzick NS: Burns. The Surgical Review: An Integrated Basic and Clinical Science Study Guide, Kreisel D, Krupnick AS, Kaiser LR (eds) Lippincott-Raven, pp 123-138, 2001.

Cass DL, Adzick NS: Fetal versus Adult Wound Repair. In: Clark RAF, Davidson J, Mustoe T, Steed D (eds): Textbook of Wound Care, WB Saunders, Philadelphia, 1998 (in press).

Cass DL, Adzick NS: Fetal wound healing renaissance. In Hudson JW (ed): Oral and Maxillofacial Surgery Clinics of North America. 1998.

Cass DL, Adzick NS: Fetal wound healing: Lessons for the pediatric oculoplastic surgeon. In Katowitz JA (ed): Pediatric Oculoplastic Surgery. 1998.

Adzick NS: Fetal and neonatal wound healing. In Polin R, Fox W (eds): Fetal and Neonatal Physiology, 2nd Edition. WB Saunders Company, Philadelphia, 1997, pp 2015-2021.

Adzick NS: Wound healing: Biologic and clinical features. In Sabiston DC (ed): Textbook of Surgery: The Biological Basis of Modern Surgical Practice, 15th Edition. WB Saunders Company, Philadelphia, 1996, pp.

Adzick NS: Fetal animal and wound implant models. In Adzick NS and Longaker MT (eds): Fetal Wound Healing. Elsevier Scientific, New York, 1992, pp207-220.

Lorenz HP, Longaker MT, Adzick NS: Immunologic and infectious factors influencing wound repair. In Fonkalsrud EW and Krummel TM (eds): Infections and Immunologic Disorders in Pediatric Surgery. W.B. Saunders, Philadelphia, 1992, pp 103-111.

Adzick NS and Longaker MT: Characteristics of fetal tissue repair. In Adzick NS and Longaker MT (eds): Fetal Wound Healing. Elsevier Scientific, New York, 1992, pp 53-70.

Lorenz HP, Longaker MT, Adzick NS: Human fetal skin: Ontogeny and repair. In Adzick NS and Longaker MT (eds): Fetal Wound Healing. Elsevier Scientific, New York, 1992, pp 137-147.

Longaker MT, Adzick NS, Ehrlich HP: Fetal wound contraction. In Adzick NS and Longaker MT (eds): Fetal Wound Healing. Elsevier Scientific, New York, 1992, 149-160.

Burd DAR, Longaker MT, Adzick NS: In vitro fetal wound healing. In Adzick NS and Longaker MT (eds): Fetal Wound Healing. Elsevier Scientific, New York, 1992, pp 255-264.

Adzick NS and Longaker MT: Scarless fetal healing: Therapeutic implications. In Adzick NS and Longaker MT (eds): Fetal Wound Healing. Elsevier Scientific, New York, 1992, pp 317-323.

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