The following list of publications will help you in your search for more information. Most are written by members of the Fetal Diagnosis and Treatment team at The Children's Hospital of Philadelphia. If you are unable to obtain any of these publications, please let us know, and we will send copies to you.
Pearson EG, Flake AW. Stem cell and genetic therapies for the fetus.Semin Pediatr Surg. 2013 Feb;22(1):56-61. doi: 10.1053/j.sempedsurg.2012.10.010. Cited in PubMed; PMID 23395147. Read the abstract
Nijagal A, Mackenzie TC. Clinical implications of maternal-fetal cellular trafficking. Semin Pediatr Surg. 2013 Feb;22(1):62-5. doi: 10.1053/j.sempedsurg.2012.10.011. Cited in PubMed; PMID 23395148. Read the abstract
Laje P, Zoltick PW, Flake AW. SLAM-enriched hematopoietic stem cells maintain long-term repopulating capacity after lentiviral transduction using an abbreviated protocol. Gene Ther. 2009 Oct 29. [Epub ahead of print]
Merianos DJ, Tiblad E, Santore MT, Todorow CA, Laje P, Endo M, Zoltick PW, Flake AW. Maternal alloantibodies induce a postnatal immune response that limits engraftment following in utero hematopoietic cell transplantation in mice .J Clin Invest. 2009 Sep;119(9):2590-600. Epub 2009 Aug 3.
Peranteau WH, Heaton TE, Gu YC, Volk SW, Bauer TR, Alcorn K, Tuschong LM, Johnson MP, Hickstein DD, Flake AW. Haploidentical in utero hematopoietic cell transplantation improves phenotype and can induce tolerance for postnatal same-donor transplants in the canine leukocyte adhesion deficiency. Biol Blood Marrow Transplant. 2009 Mar;15(3):293-305.
Merianos D, Heaton T, Flake AW. In utero hematopoietic stem cell transplantation: progress toward clinical application.Biol Blood Marrow Transplant. 2008 Jul;14(7):729-40. Epub 2008 Apr 25. Review.
Endo M, Zoltick PW, Peranteau WH, Radu A, Muvarak N, Ito M, Yang Z, Cotsarelis G, Flake AW. Efficient in vivo targeting of epidermal stem cells by early gestational intraamniotic injection of lentiviral vector driven by the keratin 5 promoter. Mol Ther. 2008 Jan;16(1):131-7. Epub 2007 Oct 9
Badillo AT, Flake AW. The regulatory role of stromal microenvironments in fetal hematopoietic ontogeny. Stem Cell Rev. 2006;2(3):241-6.
Wilson, RD. Present Role of Stem Cells for Fetal Genetic Therapy. J Obstet Gynaeco Can 2005;27(11):1038-1042.
Wilson, RD. Amended Canadian Guideline for Prenatal Diagnosis (2005) Change to 2005-Techniques for Prenatal Diagnosis. J Obstet Gynaecol Can 2005;27(11):1048-1054.
Flake AW. The conceptual application of systems theory to stem cell biology: A matter of context. Blood Cells, Molecules, and Diseases 32: 58-64, 2004.
Javazon EH, Merchant AM, Danzer E, Flake AW. Reconstitution of hematopoiesis following intrauterine transplantation of stem cells. Methods in Molecular Medicine 105:81-94, 2004.
Javazon EH, Beggs KJ, Flake AW. Mesenchymal Stem Cells: Paradoxes of Passaging. Experimental Hematology 32:414-25, 2004.
Hayashi S, Hsieh MH, Peranteau WH, Ashizuka S, Flake AW. Complete allogeneic hematopoietic chimerism achieved by in utero hematopoietic cell transplantation and co-transplantation of LLME treated, MHC sensitized, donor lymphocytes. Experimental Hematology 32:290-299, 2004.
Hayashi S, Abdulmalik O, Peranteau WH, Ashizuka S, Campagnoli C, Chen Q, Horiuchi K, Asakura T, Flake AW. Mixed chimerism following in utero hematopoietic stem cell transplantation in murine models of hemoglobinopathy. Experimental Hematology 31:176-184, 2003.
Hayashi S, Peranteau W, Shaaban AF, Flake AW. Complete allogeneic hematopoietic chimerism achieved by a combined strategy of in utero hematopoietic stem cell transplantation and postnatal donor lymphocyte infusion. Blood 100:804-812, 2002.
MacKenzie TC, Kobinger GP, Kootstra NA, Radu A, Sena-Esteves M, Bouchard S,Wilson JM, Verma IM, Flake AW. Efficient transduction of liver and muscle after in utero injection of lentiviral vectors with different pseudotypes. Molecular Therapy 6:349-358, 2002.
Peranteau WH, Hayashi S, Hsieh M, Shaaban AF, Flake AW. High level allogeneic chimerism achieved by a strategy of prenatal tolerance induction and postnatal non-myeloablative bone marrow transplantation. Blood 100:2225-2234, 2002.