Fetal Stem Cell Transplantation, In Utero Stemm Cell Publications | The Children's Hospital of Philadelphia

Center for Fetal Diagnosis and Treatment

Publicaciones sobre trasplante de células madre in útero 

La siguiente lista de publicaciones le será de utilidad en su búsqueda de información. La mayoría han sido escritas por integrantes del equipo de Diagnóstico y Tratamiento Fetal del Children’s Hospital of Philadelphia. Si no puede obtener alguna de estas publicaciones, por favor avísenos, y le enviaremos copias.

Journal articles

2012

Nijagal A, Flake AW, MacKenzie TC. In utero hematopoietic cell transplantation for the treatment of congenital anomalies. Clin Perinatol. 2012 Jun;39(2):301-10.

Roybal JL, Laje P, Vrecenak JD, Flake AW. Use of manipulated stem cells for prenatal therapy. Methods Mol Biol. 2012;891:169-81.

2010

Laje P, Zoltick PW, Flake AW. SLAM-enriched hematopoietic stem cells maintain long-term repopulating capacity after lentiviral transduction using an abbreviated protocol. Gene Ther. 2010 Mar;17(3):412-8.

Roybal JL, Santore MT, Flake AW. Stem cell and genetic therapies for the fetus. Semin Fetal Neonatal Med. 2010 Feb;15(1):46-51.

2009

Merianos DJ, Tiblad E, Santore MT, Todorow CA, Laje P, Endo M, et al. Maternal alloantibodies induce a postnatal immune response that limits engraftment following in utero hematopoietic cell transplantation in mice. J Clin Invest. 2009 Sep;119(9):2590-600.

Santore MT, Roybal JL, Flake AW. Prenatal stem cell transplantation and gene therapy. Clin Perinatol. 2009 Jun;36(2):451-71, xi.

Peranteau WH, Heaton TE, Gu YC, Volk SW, Bauer TR, Alcorn K, et al. Haploidentical in utero hematopoietic cell transplantation improves phenotype and can induce tolerance for postnatal same-donor transplants in the canine leukocyte adhesion deficiency model. Biol Blood Marrow Transplant. 2009 Mar;15(3):293-305.

2008

Merianos D, Heaton T, Flake AW. In utero hematopoietic stem cell transplantation: progress toward clinical application. Biol Blood Marrow Transplant. 2008 Jul;14(7):729-40.

2007

Peranteau WH, Endo M, Adibe OO, Flake AW. Evidence for an immune barrier after in utero hematopoietic-cell transplantation. Blood. 2007 Feb 1;109(3):1331-3.

2006

Peranteau WH, Endo M, Adibe OO, Merchant A, Zoltick PW, Flake AW. CD26 inhibition enhances allogeneic donor-cell homing and engraftment after in utero hematopoietic-cell transplantation. Blood. 2006 Dec 15;108(13):4268-74.

Ashizuka S, Peranteau WH, Hayashi S, Flake AW. Busulfan-conditioned bone marrow transplantation results in high-level allogeneic chimerism in mice made tolerant by in utero hematopoietic cell transplantation. Exp Hematol. 2006 Mar;34(3):359-68.

Badillo AT, Flake AW. The regulatory role of stromal microenvironments in fetal hematopoietic ontogeny. Stem Cell Rev. 2006;2(3):241-6.

2005

Javazon EH, Merchant AM, Danzer E, Flake AW. Reconstitution of hematopoiesis following intrauterine transplantation of stem cells. Methods Mol Med. 2005;105:81-94.

2004

Hayashi S, Hsieh M, Peranteau WH, Ashizuka S, Flake AW. Complete allogeneic hematopoietic chimerism achieved by in utero hematopoietic cell transplantation and cotransplantation of LLME-treated, MHC-sensitized donor lymphocytes. Exp Hematol. 2004 Mar;32(3):290-9.

Flake AW. The conceptual application of systems theory to stem cell biology: a matter of context. Blood Cells Mol Dis. 2004 Jan-Feb;32(1):58-64.

2003

Hayashi S, Abdulmalik O, Peranteau WH, Ashizuka S, Campagnoli C, Chen Q, Horiuchi K, Asakura T, Flake AW. Mixed chimerism following in utero hematopoietic stem cell transplantation in murine models of hemoglobinopathy. Exp Hematol. 2003 Feb;31(2):176-84.

2002

Peranteau WH, Hayashi S, Hsieh M, Shaaban AF, Flake AW. High-level allogeneic chimerism achieved by prenatal tolerance induction and postnatal nonmyeloablative bone marrow transplantation. Blood. 2002 Sep 15;100(6):2225-34.

Hayashi S, Peranteau WH, Shaaban AF, Flake AW. Complete allogeneic hematopoietic chimerism achieved by a combined strategy of in utero hematopoietic stem cell transplantation and postnatal donor lymphocyte infusion. Blood. 2002 Aug 1;100(3):804-12.

Mackenzie TC, Shaaban AF, Radu A, Flake AW. Engraftment of bone marrow and fetal liver cells after in utero transplantation in MDX mice. J Pediatr Surg. 2002 Jul;37(7):1058-64.

2001

Mackenzie TC, Flake AW. Multilineage differentiation of human MSC after in utero transplantation. Cytotherapy. 2001;3(5):403-5.

MacKenzie TC, Shaaban AF, Radu A, Flake AW. Treatment of muscular dystrophy by in utero stem cell transplantation. Surgical Forum LII:328-29, 2001

2000

Sylvester KG, Nesbit M, Radu A, Herlyn M, Adzick NS, Crombelholme TM: Adenoviral-mediated gene transfer in wound healing: Acute inflammatory response in human skin in the SCID mouse model. Wound Repair and Regeneration 8:36-44, 2000.

Liechty KW, MacKenzie TC, Shaaban AF, Radu A, Moseley AB, Deans R, Marshak DR, Flake AW: Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nature Medicine 6:1282-1286, 2000.

1999

Kim HB, Shaaban AF, Milner R, Fichter C, Flake AW. In utero bone marrow transplantation induces tolerance by a combination of clonal deletion and anergy. J Pediatr Surg. 1999 May;34(5):726-9; discussion 729-30.

Milner R, Shaaban AF, Kim HB, Fichter C, Flake AW. Postnatal booster injections increase engraftment after in utero stem cell transplantation. J Surg Res. 1999 May 1;83(1):44-7.

1998

Zanjani ED, Almeida-Porada G, Livingston AG, Flake AW , Ogawa M. Human bone marrow CD34- cells engraft in vivo and undergo multilineage expression including giving rise to CD34+ cells. Experimental Hematology, 26:353-360, 1998.

Flake AW, Zanjani ED. In Utero Transplantation for Thalassemia. Annals of the New York Academy of Sciences 850:300-311, 1998.

Leahey AM, Shears GJ, Smith CA, Flake AW, Sullivan KE. Successful use of extracorporeal membrane oxygenation (ECMO) as a bridge to reconstitution following BMT for SCID. Bone Marrow 21:839-840, 1998.

Kim HB, Shaaban AF, Yang EY, Liechty KW, Flake AW. Microchimerism and tolerance after in utero bone marrow transplantation in mice. Journal of Surgical Research 77:1-5, 1998.

Porada CD, Tran N, Eglitis M, Moen RC, Troutman L, Flake AW, Zhao Y, Anderson WF, Zanjani ED. In utero gene therapy: Transfer and long term expression of the bacterial neoR gene in sheep following direct injection of retroviral vectors into pre-immune fetuses. Human Gene Therapy 9:1571, 1998.

Shaaban AF, Kim HB, Milner R, Fichter C. Flake AW. Pretreatment of prenatally transplanted allogeneic marrow with VEGF and SCF delays allograft rejection in chimeric mice. Surgical Forum XLIX:380-81, 1998.

Milner R, Kim HB, Shaaban AF, Fichter C, Scully M, Asakura T, Flake AW. In utero HSC transplantation in mice transgenic for human hemoglobinopathy - Selective advantage for donor red cells. Surgical Forum XLIX:471 2, 1998.

Kim HB, Shaaban AF, Milner R, Fichter C, Flake AW. In utero bone marrow transplantation induces tolerance by a combination of clonal deletion and anergy. Surgical Forum XLIX:353-4, 1998.

Flake AW, Zanjani ED. In Utero Transplantation for Thalassemia. Ann N Y Acad Sci. 1998 Jun 30;850:300-11.

Zanjani ED, Almeida-Porada GD, Ascensao JL, MacKintosh FR, Flake AW. Transplantation of hematopoietic stem cells in utero. Stem Cells (in press) 1998.

Zanjani ED, Almeida-Porada G, Porada C, Flake AW. In Utero Approach to Hematopoietic Stem Cell Transplantation. Proceedings of the Nobel Symposium. Stockholm, Sweden, (in press) 1998.

Kim HB, Shaaban MD, Yang EY, Liechty KW, Flake AW. Microchimerism and tolerance after in utero bone marrow transplantation in mice. J Surg Res. 1998 Jun;77(1):1-5.

1997

Flake AW, Zanjani ED. In Utero Hematopoietic Stem Cell Transplantation: A Status Report. Journal of the American Medical Association 278:932-937, 1997.

Flake AW, Zanjani ED: Cellular therapy. New Trends and Controversies in Fetal Diagnosis and Therapy. Reece EA (eds.), Obstetrics and Gynecology Clinics of North America. 24:159-177, 1997.

1996

Flake AW, Roncarolo M-G, Puck JM, Ameida-Porada G, Evans MI, Johnson MP, Abella EM, Harrison DD, Zanjani ED. Treatment of X-linked Severe Combined Immunodeficiency(X-SCID) by the in utero transplantation of paternal bone marrow. New England Journal of Medicine 335:1806-1810, 1996.

Kawashima I, Zanjani ED, Almaida-Porada G, Flake AW, Zeng H, Ogawa M. CD34+ human marrow cells that express low levels of Kit protein are enriched for long-term marrow-engrafting cells. Blood 87:4136-42, 1996.

Zanjani ED, Almeida-Porada GD, Flake AW. The human/sheep xenograft model: a large animal model of human hematopoiesis. International Journal of Hematology. 63:179-192, 1996.

Flake AW, Roncarolo MG, Puck JM, Almeida-Porada G, Evans MI, Johnson MP, Abella EM, Harrison DD, Zanjani ED. Treatment of X-Linked Severe Combined Immunodeficiency by In Utero Transplantation of Paternal Bone Marrow. The New England Journal of Medicine. 335:1806-1810, 1996.

1995

Bethel CAI, Steinkirchner T, Zanjani ED, Flake AW: The stromal microenvironment of human fetal hematopoiesis; in vitro morphologic studies. Pathobiology 62:99-103, 1995.

Rice HE, Skarsgard ED, Emani VR, Harrison MR, Zanjani ED, Flake AW: An effective strategy for decontamination, ex vivo expansion, and storage of human fetal liver hematopoietic stem cells. Transplantation Proceedings 26:3352-3, 1995.

Rice HE, Hendrick MH, Flake AW: In-utero transplantation of rat hematopoietic stem cells induces xenogeneic chimerism in mice. Transplantation Proceedings 26:126-128, 1995.

Flake AW, Hendrick MH, Rice HE, Tavassoli M, Zanjani ED: Enhancement of human hematopoieses by mast cell growth factor in human-sheep chimeras created by the in-utero transplantation of human fetal hematopoietic cells. Experimental Hematology 23:252-257, 1995.

Zanjani ED, Almeida-Porada G, Flake AW: Engraftment and multilineage expression of human hematopoietic stem cells in human-sheep chimeras. Stem Cells 13:101-111, 1995.

Zanjani ED, Flake AW: In utero hematopoietic stem cell transplantation. New Trends in Therapy 234:597-603, 1995.

1994

Zanjani ED, Flake AW, Rice HE, Hedrick MH, Tavassoli M: Long-term hematopoietic repopulating ability of enogenic transplanted human fetal liver stem cell (HSC) in sheep. Journal of Clinical Investigation 93:1051 1055, 1994.

Rice HE, Emani VR, Skarsgard ER, Knazek RA, Zanjani ED, Flake AW, Harrison MR: Human fetal liver hematopoietic cell expansion with a novel biorector system. Transplantation Proceedings 26:3338-3339, 1994.

Crombleholme TM, Bianchi DW: In utero hematopoietic stem cell transplantation and gene therapy. Sem in Perinatol 18 (4): 376-384, 1994.

Hedrick MH, Rice HE, MacGillvray TE, Bealer JF, Zanjani ED, Flake AW: Hematopoietic chimerism achieved by in-utero hematopoietic stem cell injection does not induce donor specific tolerance or renal allografts in sheep. Transplantation 58:110-111, 1994.

Zanjani ED, Silva MRG, Flake AW: Retention and multilineage expression of human hematopoietic stem cells in human-sheep chimeras. Blood Cells 20:331-340, 1994.

Zanjani, ED, Silva, MR, Flake, AW. Retention and multilineage expression of human hematopoietic stem cells in human-sheep chimeras. Blood Cells 20:331-338, 1994.

1993

Flake AW, Harrison MR, Zanjani ED: In Utero Transplantation of Hematopoietic Stem Cells. Critical Reviews in Oncology/Hematology 15-35-48, 1993.

Flake AW, Zanjani ED: In-utero transplantation of hematopoietic stem cells. Critical Reviews in Oncology/Hematology 15:35-48, 1993.

Hedrick MH, Rice HE, Zanjani ED, Sachs DH, Flake AW. Creation of pig-sheep xenogeneic chimerism by the in-utero transplantation of hematopoietic stem cells. Transplantation Science 3:23-26, 1993.

Rice HE, Flake AW, Hedrick MH, Zanjani ED, Harrison MR: Effect of xenogeneic chimerism in a human/sheep model on natural antibody. Journal of Surgical Research 54:355-359, 1993.

Rice HE, Hedrick MH, Flake AW, Donegan E, Harrison MR: Bacterial and fungal contamination of human fetal liver collected transvaginally for hematopoietic stem cell transplantation. Fetal Diagnosis and Therapy 8:74 78, 1993.

Srour, EF, Zanjani ED, Cornetta K, Traycoff CM, Flake AW, Hedrick M, Brandt JE, Leemhuis T, Hoffman R: Persistence of human multilineage self-renewing lymphohematopoietic stem cells in chimeric sheep. Blood 82:3333-3342, 1993.

1992

Duncan BD, Harrison MR, Crombleholme TM, Clemons G, Tavassole, Zanjani ED: Effect of erythropoietic stress on donor hematopoietic cell expression in chimeric rhesus monkeys transplanted in utero. Experimental Hematology 20 (3): 350-353, 1992.

Zanjani ED, Pallavacini MG, Ascensao JL, Flake AW, Harrison MR, Tavassoli M.: Human-ovine xenogeneic transplantation of stem cells in-utero. Bone Marrow Transplantation 9 Suppl 1:86-9, 1992.

Zanjani ED, Ascensao JL, Flake AW, Harrison MR, Tavassoli M: The fetus as an optimal donor and recipient of hemopoietic stem cells. Bone Marrow Transplantation 10 Suppl 1:107-14, 1992.

Zanjani ED, Pallavicini MG, Ascencao JL, Flake AW, Resima M, MacKintosh FR, Langlois R, Stutes D, Harrison MR, and Tavassoli M. Engraftment and long term expression of human fetal hemopoietic stem cells in sheep following transplantation in-utero. Journal of Clinical Investigation 89:1178-1188, 1992.

1991

Burke EC, Bethel CAI, Flake AW, Freise CE, Ascher NL. Isolation, MHC expression and function of isolated fetal hepatocytes from fetal livers preserved in UW solution. FASEB Journal 5:623, 1991

Crombleholme TM, Langer JC, Harrison MR, Zanjani ED: Transplantation of fetal cells. Am J Obstet Gynecol 164 (1 Pt 1): 218-230, 1991.

Duncan BW, Harrison MR, Zanjani ED, Tarantal AF, Adzick NS, Longaker MT, Roberts LJ, Bigler ME, Roncarolo M-G: Immunologic evaluation of hematopoietic chimeric rhesus monkeys. Transplantation Proceedings 23:841-843, 1991.

Duncan BW, Harrison MR, Flake AW, Bethel CI, Bigler ME, Roncorolo MG: Immune response in hematopoietic chimeric rhesus monkeys. Surgical Forum XLII:373-375, 1991.

Flake AW, Harrison MR, Zanjani ED: Transplantation of hematopoietic stem cells in-utero. Experimental Hematology 19:1061-1064, 1991.

Pallavicini MG, Flake AW, Bethel C, Langlois R, Madden D, Duncan BW, Haendel S, Montoya T: Creation of human-mouse xenogeneic chimeras by the in-utero transplantation of hemopoietic cells. Transplantation Proceedings 24:542-543, 1991.

1990

Crombleholme TM, Harrison MR, Zanjani ED: Transplantation of hematopoietic stem cells in utero: The role of donor T-cells in engraftment and the development of GVHD. J Pediatr Surg 25(8): 885-892, 1990.

1989

Harrison MR, Slotnick RN, Crombleholme TM, Tarantal AF, Golbus MS, Zanjani ED: In-Utero transplantation of fetal liver haemopoietic stem cells in monkeys. Lancet 2(8677): 1425-1427, 1989.

1988

Crombleholme TM, Longaker MT, Langer JC, Slotnick RN, Tarantal AF, Zanjani ED, Harrison MR: In utero hematopoietic stem cell transplantation in primates. Surg Forum 39:564-566, 1988.

1986

Flake AW, Harrison MR, Adzick NS, Zanjani ED: Transplantation of fetal hematopoietic stem cells in utero: The creation of hematopoietic chimeras. Science 233:776-778, 1986.

Chapters

Flake AW: In utero hematopoietic stem cell transplantation. Fetal Medicine: Basic Science and Clinical Practice. Rodeck CH and Whittle MJ (eds.), Harcourt Brace & Co. Ltd. , London, Chapter 67, pp. 887-897, 1999.

Flake AW, Zanjani ED. In Utero Transplantation. In Hematopoietic Cell Transplantation. Second Edition. Forman SJ, Bloom KG, and Thomas ED (eds), Blackwell Science Inc., Malden, MA, Chapter 42, pp. 444-454, 1999.

Flake AW, Zanjani ED. Fetal Stem Cell Therapy. In Medicine of the Fetus and Mother. Second Edition. Reece EA, Hobbins J (eds.), Lippincott-Raven Publishers, Philadelphia, Chapter 50, pp. 891-902, 1998.

Flake AW: Treatment of X-linked Severe Combined Immunodeficiency by the in utero transplantation of hematopoietic stem cells: Case report. In Stem Cell Therapy of Inherited Hematopoietic Disorders. Migliaccio AR and Alessandrini L (eds.) Instituto Superiore Di Sanita, Rapporti ISTISAN, pp 47-51, 1998.

Flake AW, Zanjani ED. In Utero Transplantation. In Hematopoietic Cell Transplantation. Second Edition. Forman SJ, Bloom KG, and Thomas ED (eds) Chapter 41, Blackwell Science Inc., Malden, MA, (in press) 1998.

Flake AW: In utero hematopoietic stem cell transplantation. Fetal Medicine: Basic Science and Clinical Practice. Rodeck CH and Whittle MJ (eds.), (in press), 1998.

Flake AW, Zanjani ED. Fetal Stem Cell Therapy. In Medicine of the Fetus and Mother. Second Edition. Reece EA, Hobbins J (eds.) Chapter 50, Lippincott-Raven Publishers, Philadelphia, (in press) 1998.

Kim HB, Shaaban AF, Flake AW. Fetal Genetic Therapy - Stem Cells. In Prenatal Diagnosis: Genetics, Reproductive Risks, Testing, and Management. Evans MI, ed. , Appleton & Lange, Stamford, CT.

Flake AW: In utero hematopoietic stem cell transplantation. Diseases of the Fetus and Newborn, Second Edition, Reed G, Glaireaux A, Cockburn F, and Connor M (eds.), Chapter 88, Chapman & Hall Medical , pp. 1331-1335, 1995

Flake AW: Ontogeny of fetal immunity. In infections and immunologic problems in pediatric surgical patients. Fonkalsrud EW, (ed.) WB Saunders Co., Orlando, Fl, Chapter 3, pp. 9-21, 1993.

Flake AW. The Fetus with a Hematopoietic Stem Cell Defect. The Unborn Patient. The Art and Science of Fetal Therapy, 3rd Edition, Harrison MR, Evans MI, Adzick NA, Holtzgreve W, (eds.), W.B. Saunders Co., Orlando, FL, 2000.

Kim HB, Shaaban AF, Flake AW. Fetal Genetic Therapy - Stem Cells. In Prenatal Diagnosis: Genetics, Reproductive Risks, Testing, and Management. Evans MI, ed., Appleton & Lange, Stamford, CT, 1999.

Shaaban AF, Flake AW. Fetal Hematopoietic Stem Cell Transplantation. In Fetal Therapy for the 21st Century, Adzick NS (guest editor) Seminars in Perinatology, 1999.

Zanjani ED, Almeida-Porada G, Porada C, Flake AW. In Utero Approach to Hematopoietic Stem Cell Transplantation. Proceedings of the Nobel Symposium. Stockholm, Sweden, 1998.

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