Obstructive Uropathy, Fetal Intervention for Obstructive Uropathy | The Children's Hospital of Philadelphia

Center for Fetal Diagnosis and Treatment

Publicaciones sobre uropatía obstructiva

La siguiente lista de publicaciones le será de utilidad en su búsqueda de información. La mayoría han sido escritas por integrantes del equipo de Diagnóstico y Tratamiento Fetal del Children’s Hospital of Philadelphia. Si no puede obtener alguna de estas publicaciones, por favor avísenos, y le enviaremos copias.

Journal articles


Wu S, Johnson MP. Fetal lower urinary tract obstruction. Clin Perinatol. 2009 Jun;36(2):377-90, x. Review.


Biard J-M, Johnson MP, Carr M, Wilson RD, Hedrick HL, Pavlock C, Schwarz U, Flake AW, Adzick NS: Long-term outcomes in children treated by prenatal vesicoamniotic shunting for lower urinary tract obstruction (LUTO). Obstetrics and Gynecology 106:503-508, 2005.


Kirsch AJ, Macarek EJ, Chaquor B, Quinn T, Zderic SA, Flake AW, Crombleholme TM, Adzick NS, Canning D, Hubbard AM, Rosenbloom, Snyder HM, Howard PS: Molecular response of the bladder to obstruction. Adv Exp Med Biol 539: 195-216, 2004.


Kirsch AJ, Macarak EJ, Chaqour B, Quinn T, Zderic S, Flake AW, Crombleholme TM, Adzick NS, Canning D, Hubbard AM, Rosenbloom J, Snyder HM, Howard PS. Molecular response of the bladder to obstruction. Adv Exp Med Biol. 2003;539(Pt A):195-216


Austin JC, Canning DA, Johnson MP, Flake AW, Carr MC. Vesicoamniotic shunt in a female fetus with prune belly syndrome. Journal of Urology 166:2382-2383, 2001.


Freedman, AL, Johnson MP, Smith CA, Gonzalez R, Evans MI: Long-term outcome in children after antenatal intervention for obstructive uropathies. Lancet 354: 374-377, 1999.


Freedman AL, Qureshi F, Shapiro E, Lepor H, Jacques SM, Evans MI, Smith CA, Gonzales R, Johnson MP. Smooth muscle development in the obstructed fetal bladder. Urology 49:104-107, 1997.

Freedman AL, Bukowski TP, Smith CA, Evans MI, Berry SM, Gonzalez R, Johnson MP. The use of urinary B2 microglobulin to predict renal dysplasia in fetal obstructive uropathy. Fetal Diagnosis and Therapy 12 (1):1-6, 1997.


Freedman AL, Bukowski TP, Smith CA, Evans MI, Quintero R, Gonzales R, Johnson MP. Fetal therapy for obstructive uropathy: diagnosis specific outcomes. Urology 156:720-24, 1996.

Johnson MP, Flake AW: Modifications of technique based on hard lessons learned. Dialogues in Pediatric Urology-Advances in Fetal Therapy for Obstructive Uropathy 19(4):5, 1996.

Morin L, Cendron M, Crombleholme TM, Garmel SH, Klauber G, D'Alton ME: Minimal hydronephrosis in the fetus: clinical significance and implications for management. J Urol 155 (6): 2047-2049, 1996.

Garmel S, Crombleholme TM, Cendron M, Klauber G, D'Alton ME: The vanishing fetal ureterocele: A cause for concern? Prenatal Diag 16 (4): 354-356, 1996.

Quintero RA, Johnson MP, Arias F, Cortez K, Carreno C, Romero R, Evans MI. In utero sonographic diagnosis of vesicoureteral reflux by percutaneous vesicoinfusion. Ultrasound Obstet Gynecol 6: 386-389, 1996.

Qureshi F, Jacques SM, Seifman B, Quintero RA, Evans MI, Smith C, Johnson MP. In utero fetal urine analysis and renal histology do correlate with outcome in fetal obstructive uropathies. Fetal Diagnosis and Therapy 11:306-312, 1996

Tomlinson M, Johnson MP, Goncalves L, King M, Freedman A, Smith C, Reichler A, Evans MI. Correction of hemodynamic abnormalities by vesicoamniotic shunting in familial congenital megacystis. Fetal Diagnosis & Therapy 11: 46-49, 1996.


Berry SM, Lecolier B, Smith RS, Bercau G, Dombrowski MP, Puder KS, Kithier K, Bidat L, Johnson MP, Cotton DB. Fetal serum beta-2 microglobulin is a possible predictor of neonatal renal function. Lancet 345(8960): 1277-1278, 1995.

Johnson MP, Corsi P, Bradfield W, Hume RF, Smith C, Flake AW, Qureshi F, Evans MI: Sequential fetal urine analysis provides greater precision in the evaluation of fetal obstructive uropathy. Am J Obstet Gynecol 173:59-65, 1995.

Johnson MP, Corsi P, Bradford W, Hume RF, Smith C, Flake AW, Quereshi F, Evans MI.: Sequential fetal urine analysis provides greater precision in the evaluation of fetal obstructive uropathy. American Journal of Obstetrics and Gynecology 173:59-65, 1995.

Quintero RA, Hume RF, Johnson MP, Smith C, Cotton DB, Romero R, Evans MI: Percutaneous fetal cystoscopy, and endoscopic fulguration of posterior urethral valves. Am J Obstet Gynecol 172: 206-209, 1995.

Quintero RA, Johnson MP, Romero R, Smith C, Arias F, Guevara-Zuloaga F, Cotton DB, Evans MI. In-utero percutaneous cystoscopy in the management of fetal lower obstructive uropathy. Lancet 346:537-540, 1995.


Johnson MP, Bukowski TP, Reitleman C, Isada NB, Pryde PG, Evans MI: In utero surgical treatment of fetal obstructive uropathy: A new comprehensive approach to identify appropriate candidates for vesicoamniotic shunt therapy. Am J Obstet Gynecol 170(6): 1770-1779, 1994.


Supulveda W, Berry SM, Romero R, King ME, Johnson MP, Cotton DB: Prenatal diagnosis of congenital megalourethra. J Ultrasound in Medicine 12: 761-766, 1993.


Evans MI, Sacks AL, Johnson MP, Robichaux III AG, May M, Moghissi KS: Sequential invasive assessment of fetal renal function, and the in utero treatment of fetal obstructive uropathies. Obstet Gynecol 77(4): 545-550, 1991.


Crombleholme TM, Harrison MR, Galbus MS, Longaker MT, Langer JC, Filly RF, Anderson RL, Callen PW, Goldstein R: Fetal intervention in obstructive uropathy: Prognostic indicators and efficacy of intervention. Am J Obstet Gynecol 162(5):1239-1244, 1990.


Longaker MT, Adzick NS, Harrison MR: Fetal obstructive uropathy. Brit Med Journal 299:325, 1989.


Hu LM, Davies P, Adzick NS, Harrison MR, Reid L: Lung growth after intrauterine bilateral ureteral obstruction. Fed Proc 46:1151a, 1987.

Harrison MR, Golbus MS, Filly RA, Anderson RL, Flake AW, Rosen M, Huff RW: Fetal hydronephrosis: Selection and surgical repair. Journal of Pediatric Surgery 22:556-8, 1987.

Adzick NS, Harrison MR, Hu L, Davies P, Flake AW, Reid LM: Pulmonary hypoplasia and renal dysplasia in a fetal lamb urinary tract obstruction model. Surg Forum 38:666-668, 1987.


Sauer L, Glick PL, Adzick NS, Harrison MR: Compensatory renal growth following nephrectomy in fetal lambs. Surg Forum 37:648-650, 1986.

Flake AW, Harrison MR, Adzick NS, deLorimier AA: Ureteropelvic junction obstruction in the fetus. J Pediatr Surg 21:1058-1063, 1986.

Adzick NS, Harrison MR, Glick PL, deLorimier AA: Temporary cutaneous umbilical vesicotomy in premature infants with urethral obstruction. J Pediatr Surg 21:158, 1986.


Adzick NS, Harrison MR, Flake AW, Glick PL: Fetal urinary tract obstruction: Experimental pathophysiology. Sem Perinatol 9:79-90, 1985.

Adzick NS, Harrison MR, Flake AW, deLorimier AA: Urinary extravasation in the fetus with obstructive uropathy. J Pediatr Surg 20:608-615, 1985.

Glick PL, Harrison MR, Adzick NS, Filly RA, Callen PW, Mahoney BS, Anderson RL, Golbus MS, deLorimier AA: Management of the fetus with congenital hydronephrosis II: Diagnostic assessment and selection for treatment. J Pediatr Surg 20:376-87, 1985.

Adzick NS, Harrison MR, Flake AW, Laberge JM, Villa RL: Development of a fetal renal function test using endogenous creatinine clearance. J Pediatr Surg 20:602-607, 1985.


Adzick NS, Harrison MR, Glick PL, Villa RL, Finkbeiner W: Experimental pulmonary hypoplasia and oligohydramnios: Relative contributions of lung fluid and fetal breathing movements. J Pediatr Surg 19:658-665, 1984.

Glick PL, Harrison MR, Halks-Miller M, Adzick NS, Nakayama DK, Edwards MSB: Correction of congenital hydrocephalus in utero II. Efficacy of in utero shunting. J Pediatr Surg 19:870-881, 1984.

Glick PL, Harrison MR, Adzick NS, Noall RA, Villa R: Correction of congenital hydronephrosis in utero IV. In utero decompression prevents renal dysplasia. J Pediatr Surg 19:649-657, 1984. 


Lovvorn H, Adzick NS: Fetal obstructive uropathy. In Pollack HM, McClennan BL (eds): Clinical Urography, second edition, WB Saunders Co, Philadelphia, 1998.

Jennings RW, Adzick NS, Harrison MR: Fetal intervention for obstructive uropathy. In O'Donnell BA, Koff SA (ed): Paediatric Urology, 3rd Edition. Butterworth Scientific, Surrey, England; 1997, pp. 330-338.

Johnson MP, Flake AW, Quintero RA, Evans MI: Fetal Shunt Procedures. In Invasive Outpatient Procedures in Reproductive Medicine. Evans MI, Johnson MP, and Moghissi KS (eds.) Lippencott-Raven Publishers. Philadelphia. pp. 61-90, 1997.

Jennings RW, Adzick NS, Harrison MR: Fetal intervention for obstructive uropathy. In O'Donnell BA, Koff SA (ed): Paediatric Urology, 2nd Edition. Butterworth Scientific, Surrey, England; 1992, pp. 48-62.

Adzick NS, Harrison MR: Fetal surgery for congenital hydronephrosis. In Quilligan EJ, Zuspan FP (eds): Current Therapy in Obstetrics and Gynecology. WB Saunders Co., Philadelphia, 1990, pp 333-338.

Flake AW, Adzick NS, Glick PL, Harrison MR: Evaluation of the fetus with hydronephrosis. In White RDW and Palmer JM (ed): New Techniques in Urology, Futura Publishing, NY, 1987, pp 269-285, 1988.

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