Pediatric Comprehensive Bone Marrow Failure Center

Pediatric Comprehensive Bone Marrow Failure Center

Bone marrow failure has multiple causes – some acquired and some inherited. Families often come to the Pediatric Comprehensive Bone Marrow Failure Center at The Children's Hospital of Philadelphia to establish a comprehensive treatment plan, receive a diagnosis or get a second opinion.

If you are concerned that your child may carry one of these diagnoses or has developed bone marrow failure, we would be happy to see him or her in one of our clinics. Bone marrow failure syndromes are diagnostically and therapeutically challenging, and the clinical expertise here can be helpful in making a thoughtful plan.

Our Pediatric Comprehensive Bone Marrow Failure Program is led by Dr. Monica Bessler, who coordinates clinical care and research in bone marrow failure to provide the best care and most current treatments available. We offer complete diagnostic, therapeutic and support services for children with acquired and inherited bone marrow disorders including:

Our physicians work with a team of nurses, fellows and social workers to provide a thorough, multidisciplinary evaluation and comprehensive care. After reviewing medical records and test results and meeting with the family, we discuss the patient’s overall health, recommend necessary diagnostic evaluations and outline treatment options. We then provide the patient’s family and referring physician with a written summary that includes treatment recommendations. We also assist with prevention efforts, initiation and surveillance of treatment response, and monitoring of late complications.

Our medical and transfusion therapies have achieved results that are among the best nationally.  

For more information on bone marrow failure including causes, treatments and research, please visit us at

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