Center for Pediatric Inflammatory Bowel Disease

Recent Publications

2009

Ingerski LM, Baldassano RN, Denson LA, Hommel KA. (2009) Barriers to Oral Medication Adherence for Adolescents with Inflammatory Bowel Disease. Journal of Pediatric Psychology, 1-9. Read abstract

Gupta N, Bostrom AG, Kirschner BS, Ferry GD, Gold BD, Cohen SA, et al. (2009). Incidence of stricturing and penetrating complications of Crohn's disease diagnosed in pediatric patients. Inflammatory Bowel Diseases. 2009 Sept. 6 (Epub ahead of print)  Read abstract

Wang K, Zhang H, Kugathasan S, Annese V, Bradfield JP, Russell RK, (2009). Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease. American Journal of Human Genetics, 84, 399 -405 Read abstract.

Colletti RB, Baldassano RN, Milov DE, Margolis PA, Bousvaros A, Crandall WV, et al. (2009). Variation in care in pediatric Crohn Disease. Journal of Pediatric Gastroenterology and Nutrition, 49(3), 297–303. Read abstract

Crandall W, Hyams J, Kugathasan S, Griffiths A, Zrubek J, Olson A, et al. (2009). Infliximab Therapy in Children With Concurrent Perianal Crohn Disease: Observations From REACH. Journal of Pediatric Gastroenterology and Nutrition, 49(2), 183–190 Read abstract

Liu S, Russo PA, Baldassano RN, Sullivan KE. (2009). CD68 expression is markedly different in Crohn's disease and the colitis associated with chronic granulomatous disease. Inflammatory Bowel Disease, 15, 1213-1217. Read abstract

Miele E, Pascarella F, Giannetti E, Quaglietta L, Baldassano RN, Staiano A. (2009) Effect of a probiotic preparation (VSL#3) on induction and maintenance of remission in children with ulcerative colitis. American Journal of Gastroenterology, 104:437–443. Read abstract

Heyman MB, Garnett EA, Shaikh N, Huen K, Jose FA, Harmatz P, Winter HS, et al. (2009) Folate concentrations in pediatric patients with newly diagnosed inflammatory bowel disease. American Journal of Clinical Nutrition, 89, 545-550. Read abstract

Dubner SE, Shults J, Baldassano RN, Zemel BS, Thayu M, Burnham JM, et al. (2009). Longitudinal assessment of bone density and structure in an incident cohort of children with Crohn's disease. Gastroenterology,136, 123 -130 Read abstract

Hommel KA, Davis CM, Baldassano RN. (2009). Objective versus subjective assessment of oral medication adherence in pediatric inflammatory bowel disease. Inflammatory Bowel Disease, 15, 589-59. Read abstract

Jose FA, Garnett EA, Vittinghoff E, Ferry GD, Winter HS, Baldassano RN, et al. (2009). Development of extraintestinal manifestations in pediatric patients with inflammatory bowel disease. Inflammatory Bowel Disease, 15, 63-68. Read abstract

Imielinski M, Baldassano RN, Griffiths A, Russell RK, Annese V, Dubinsky M, Kugathasan S, Bradfield JP, Walters TD, Sleiman P, Kim CE, Muise A, Wang K, Glessner JT, Saeed S, Zhang H, Frackelton EC, Hou C, Flory JH, Otieno G, Chiavacci RM, Grundmeier R, Castro M, Latiano A, Dallapiccola B, Stempak J, Abrams DJ, Taylor K, McGovern D; Western Regional Research Alliance for Pediatric IBD; International IBD Genetics Consortium, Heyman MB, Ferry GD, Kirschner B, Lee J, Essers J, Grand R, Stephens M, Levine A, Piccoli D, Van Limbergen J, Cucchiara S, Monos DS, Guthery SL, Denson L, Wilson DC, Grant SF, Daly M, Silverberg MS, Satsangi J, Hakonarson H. (2009) Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet. Nov 15. [Epub ahead of print] Read abstract

2008

Perrin JM, Kuhlthau K, Chughtai A, Romm D, Kirschner BS, Ferry GD, Cohen SA, Gold BD, Heyman MB, Baldassano RN, Winter HS. Measuring quality of life in pediatric patients with inflammatory bowel disease; psychometric and clinic characteristics. J Pediatr Gastroenterol Nutr, 46(2):164-71, Feb 2008. Erratum in: J Pediatr Gastroenterol Nutr, 46(4):482, April 2008. Read abstract

Grossman AB, Baldassano RN. Specific considerations in the treatment of pediatric inflammatory bowel disease. Expert Rev Gastroenterol Hepatol, 2(1):105-24, Feb 2008. Read abstract

Holland N, Dong J, Garnett E, Shaikh N, Heun K, Harmartz P, Olivia A, Winter H, Gold B, Cohen SA, Baldassano RN, Kirschner BS, Heyman MB. Reduced Intracellular T-helper 1 Interferon-gamma in blood of newly-diagnosed children with Crohn’s disease and age-related changes in Th1/Th2 Cytokine profiles. Pediatric Research, 63(3):257-62, March 2008. Read abstract

Grant SF, Baldassano RN, Hakonarson H. Classification of genetic profiles of Crohn’s disease: a focus on the ATG16L1 gene. Expert Rev Mol Diagn, Mar 2008;8(2):199-207. Review. Read abstract

De Matos V, Russo PA, Cohen AB, Mamula P, Baldassano RN, Piccoli, DA. Frequency and clinical correlations of granulomas in children with Crohn disease. J Pediatr Gastroenterol Nutr., 46(4):392-8, April 2008. Read abstract

Liu S, Abrams D, Baldassano RN, Sullivan KE. Prevalence of chronic granulomatous disease in pediatric patients diagnosed with Crohn’s disease. Letter to Editor, Inflamm Bowel Dis, 14(5):727-8, May 2008. Read abstract

Grossman AB, Noble AJ, Mamula P, Baldassano RN. Increased dosing requirements for 6-mercaptopurine and azathioprine in inflammatory bowel disease patients six years and younger. Inflamm Bowel Dis, 14(6):750-5, June 2008. Read abstract

Gupta N, Bostrom AG, Kirschner BS, Cohen SA, Abramson O, Ferry GD, Gold BD, Winter HS, Baldassano RN, Smith T, Heyman MB. Presentation and disease course in early-compared to later-onset pediatric Crohn’s disease. Am J Gastroenterol, 103(8):2092-8, Aug 2008. Read abstract

Hommel KA, Davis CM, Baldassano RN. Medication adherence and quality of life in pediatric inflammatory bowel disease. J Pediatr Psychol, 33(8):867-74, Sept 2008. Epub March 11 2008. Read abstract

Kugathasan S*,Baldassano RN*, (*equal contribution), Bradfield JP, Sleiman PM, Imielinski M, Guthery SL, Cucchiara S, Kim CE, Frackelton EC, Annaiah K, Glessner JT, Santa E, Wilson T, Eckert AW, Bonkowski E, Shaner JL, Smith RM, Otieno FG, Peterson N, Abrams DJ, Chiavacci RM, Grundmeier R, Mamula P, Tomer G, Piccoli DA, Monos DS, Annese V, Denson LA, Grant SF, Hakonarson H. Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. Nat Genet, 40(10):1211-5, Oct 2008 . Epub Aug 31, 2008. Read abstract

Heyman MB, Garnett EA, Wojcicki J, Gupta N, Davis C, Cohen SA, Gold BD, Kirschner BS, Baldassano RN, Ferry GD, Winter HS, Kaplan S. Growth hormone treatment for growth failure in pediatric patients with Crohn’s disease. J Pediatr, 153(5):651-8, 658.e1-3, Nov 2008. Epub June 27, 2008. Read abstract

White JM, O’Connor S, Winter HS, Heyman MB, Kirschner BS, Ferry GD, Cohen SA, Baldassano RN, Smith T, Clemons T, Gold BD. Inflammatory bowel disease in African American children compared with other racial/ethnic groups in a multicenter registry. Clin Gastroenterol Hepatol, 6(12):1361-9, Dec 6, 2008. Epub Oct 9, 2008. Read abstract

Heyman MB, Garnett EA, Shaikh N, Huen K, Jose FA, Harmatz P, Winter HS, Baldassano RN, Cohen SA, Gold BD, Kirschner BS, Ferry GD, Stege E, Holland N. Folate concentrations in pediatric patients with newly diagnosed inflammatory bowel disease. Am J Clin Nutr, Dec 30, 2008. Read abstract

Thayu M, Leonard MB, Hyams JS, Crandall WV, Kugathasan S, Otley AR, Olson A, Johanns J, Marano CW, Heuschkel RB, Veereman-Wauters G, Griffiths AM, Baldassano RN; Reach Study Group. Improvement in biomarkers of bone formation during infliximab therapy in pediatric Crohn’s disease: results of the REACH study. Clin Gastroenterol Hepatol, 6(12):1378-84, Dec 2008. Read abstract

2007

Reddy KP, Markowitz JE, Ruchelli ED, Baldassano RN, Brown KA. Lamina propria and circulating Interleukin-8 in newly and previously diagnosed pediatric inflammatory bowel disease patients. Digestive Diseases and Sciences, 52(2): 365-372, Feb 2007. Epub Jan 12, 2007. Read abstract

Bousvaros A, Antonioli D, Colletti RB, Dubinsky MC, Glickman JN, Gold BD, Griffiths AM, Jevon GP, Higuchi LM, Hyams JS, Kirschner BS, Kugathasan S, Baldassano RN, Russo PA. NASPGHAN Clinical Report: Differentiating ulcerative colitis from Crohn’s disease in children and young adults: Report of a working group of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition and the Crohn’s and Colitis Foundation of America. Journal of Pediatric Gastroenterology and Nutrition, 44(5): 653-74, May 2007. Read abstract

Hyams J, Crandall W, Kugathasan S, Griffiths A, Olson A, Johanns J, Liu G, Travers S, Heuschkel, R, Markowitz J, Cohen S, Winter H, Veereman-Wauters G, Ferry G, Baldassano RN, REACH Study Group. Induction and maintenance infliximab therapy for the treatment of moderate-to-severe Crohn’s disease in children. Gastroenterology, 132(3):863-73, March 2007. Epub Dec 3, 2006. Read abstract

Rosh J, Baldassano RN. Increasing incidences of inflammatory bowel disease and decreasing surgery rates: Pediatric considerations. Letter to Editor, American Journal of Gastroenterology, 102(1):205-6, Jan 2007.

Thayu M, Shults J, Burnham JM, Zemel BS, Baldassano RN, Leonard MB. Gender differences in body composition deficits at diagnosis in children and adolescents with Crohn’s disease. Inflammatory Bowel Disease Journal, 13(9):1121-8, Sep 2007. Read abstract

Mamula P, Markowitz JE, Piccoli DA, Klimov A, Cohen L, Baldassano RN. Immune response to influenza vaccine in pediatric patients with inflammatory bowel disease, Clinical Gastroenterology and Hepatology, 5(7):851-6, Jul 2007. Epub June 4, 2007. Read abstract

Baldassano RN, Bradfield JP, Monos DS, Kim CE, Glessner JT, Casalunovo T, Frackelton EC, Otieno FG, Kanterakis S, Shaner JL, Smith RM, Eckert AW, Robinson LJ, Onyiah CC, Abrams DJ, Chiavacci RM, Skraban R, Devoto M, Grant SF, Hakonarson H. Association of the T300A non-synonymous variant of the ATG16L1 gene with susceptibility of pediatric Crohn’s disease. Gut, 56(8):1171-1173, Aug 2007.

Baldassano RN, Bradfield JP, Monos DS, Kim CE, Glessner JT, Casalunovo T, Frackelton EC, Otieno FG, Kanterakis S, Shaner JL, Smith RM, Eckert AW, Robinson LJ, Onyiah CC, Abrams DJ, Chiavacci RM, Skraban R, Devoto M, Grant SF, Hakonarson H, Association of variants of the interleukin-23 receptor (IL23R) gene with susceptibility to pediatric Crohn’s disease. Clinical Gastroenterology and Hepatology, 5(8):972-976, Aug 2007. Epub July 6, 2007.

Turner D, Grossman AB, Rosh J, Kugathasan S, Gilman AR, Baldassano RN, Griffiths AM. Methotrexate following unsuccessful thiopurine therapy in pediatric Crohn’s disease. American Journal Gastroenterology 102(12):2804-2812, Dec 2007.

Veres G, Baldassano RN, Mamula P. Infliximab therapy in children and adolescents with inflammatory bowel disease. Review Article. Drugs, 67(12): 1703-1723, 2007. Read abstract

Veres G, Baldassano RN, Mamula P. Infliximab therapy for pediatric Crohn’s disease. Expert Opin Biol Ther, 7(12):1869-80, Dec 2007.

Gupta N, Bostrom AG, Kirschner BS, Ferry GD, Winter HS, Baldassano RN, Gold BD, Abramson O, Smith T, Cohen SA Heyman MB. Gender differences in presentation and courses of disease in pediatric patients with Crohn disease. Pediatrics, 120(6):e1418-25, Dec 2007.

Noble A, Baldassano RN, Mamula P. Novel therapeutic options in the inflammatory bowel disease world. Review Article. Dig Liver Disease, 40(1):22-31, Jan 2008. Epub Nov 2007.

2006

Graham-Maar RC, Russo P, Johnson AM, Baldassano RN, Mamula P, Piccoli, DA. Cases in pediatric gastroenterology from the Children’s Hospital of Philadelphia : A 2-year-old boy with emesis and facial edema. Medscape General Medicine, 8(2): 75, 2006.

Gupta N, Cohen SA, Bostrom AG, Kirschner BS, Baldassano RN, Winter HS, Ferry GD, Smith T, Abramson O, Gold BD, Heyman MB. Risk factors for initial surgery in pediatric patients with Crohn’s disease. Gastroenterology, 2006.

Hyams J, Baldassano RN, Crandall W, Griffiths A, Mamula P, Markowitz J. Pediatric clinical trials initiative. Inflammatory Bowel Disease Journal, 2006.

Hyams J, Crandall W, Kugathasan S, Griffiths A, Olson A, Johanns J, Liu G, Travers S, Heuschkel, R, Markowitz J, Cohen S, Winter H, Veereman-Wauters G, Ferry G, Baldassano RN, REACH Study Group. Induction and maintenance infliximab therapy for the treatment of moderate-to-severe Crohn’s disease in children. Gastroenterology, 2006.

Jacobstein DA, Mamula P, Markowitz JE, Leonard M, Baldassano RN. Predictors of immunomodulator use as early therapy in pediatric Crohn’s disease. Journal of Clinical Gastroenterology, 40(2):145-148, 2006.

Kadivar K, Ruchelli ED, Markowitz JE, DeFelice ML, Strogatz ML, Kanzaria MM, Reddy KP, Baldassano RN, von Allmen D, Brown KA. Lamina propria and circulating Interleukin-8 in newly and previously diagnosed pediatric inflammatory bowel disease patients. Digestive Diseases and Sciences, 2006.