Cytomegalovirus (CMV) PCR (Qualitative) - bone marrow specimen
- LIS Mnemonic: CMVPCR
Collect
Bone marrow in EDTA anticoagulated tube
Volume Required
1 ml
Minimum Required
0.5 ml
Transport
Keep specimen at 4C
Days Performed
Daily
Reported
Same day
Reflex Testing
N/A
CPT
87496
Methodology
Amplification and detection of CMV DNA polymerase gene using TaqMan real-time PCR technology. This test is performed pursuant to an agreement with Roche Molecular Systems, Inc.
Interpretation
If positive, results are reported as cytomegalovirus DNA detected.
Reference Values
Negative or no cytomegalovirus DNA detected
Remarks
Clinical Utility: CMV infections are common and usually asymptomatic in otherwise healthy children and adults; however, the incidence and spectrum of disease in newborns and in immunocompromised hosts establish this virus as an important human pathogen. PCR of bone marrow can be helpful in patients suspected of having CMV-associated bone marrow suppression, hemophagocytic syndrome, hemolytic anemia, and an atypical lymphocytosis.
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