Lung Transplant Program

Pediatric Lung Transplant Research

The Children’s Hospital of Philadelphia Lung Transplant Program is dedicated to researching advanced lung diseases and providing the best treatment and care for pediatric lung transplant patients. Our program has earned a reputation of clinical excellence and advanced research and research funding continues to grow. Below we have feature two ongoing research studies within our program.

Viral Triggers of Alloimmunity and Autoimmunity in Pediatric Lung Transplantation

The purpose of this research study is to determine whether respiratory viral infections such as the flu or a cold can damage transplanted organs. Patients who receive lung transplants may experience rejection of the transplanted lung(s). Rejection occurs when the new lung triggers the body’s defense (immune) system. During this time, special cells are sent out to destroy the new lung and eventually the lung is not able to function as it should. In some cases, damage from viral infections may lead to rejection of the lung. If doctors are able to determine the effects of respiratory viral infections on the transplanted organ, they may be able to treat respiratory viral infections before they cause harm to the transplanted organ.

Pediatric Lung Transplant Study

The International Pediatric Lung Transplant Collaborative (IPLTC) represents the first major effort to specifically review both old and current data related to lung transplantation. The goal of conducting a study of this kind is to learn more about pediatric lung transplantation. By using the experience of many transplant centers, pediatric lung transplantation will be better understood.

The purpose of this research study is to discover what determines how pediatric lung transplants fail and succeed. All parts of the transplant process are studied, including:

  1. The transplant evaluation and the events leading up to actual transplant
  2. Specific medical information about the patient
  3. Information collected before, during and after the lung transplant surgery and any complications seen in this period
  4. All medications taken following a lung transplant
  5. The development and incidence of complications such as acute rejection, infection and complications
  6. Quality of life data
  7. Long term outcome and survival
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