Neonatology

Recent Neonatal Research Publications

The selected publications on this page feature recent studies by investigators in the Division of Neonatology.

2010

Crowley M, Kirpalani H. A rational approach to red blood cell transfusion in the neonatal ICU. Current Opinion in Pediatrics. 2010 Apr;22(2):151-7. Read the abstract

Meyer A, Nadkarni V, Pollock A, Niles D, Braga M, Babbs C, Nishisaki A, Ades AM. Evaluation of the Neonatal Resuscitation Program's recommended chest compression depth using computerized tomography imaging. Resuscitation. Epub 2010 March 9. Read the abstract

Binenbaum G, Bruno CJ, Forbes BJ, Snyder MA, Mollen TJ, Schmidt B, Peterside I. Periocular ulcerative dermatitis associated with gentamicin ointment prophylaxis in newborns. J Pediatr 2010;156:320-321. Read the abstract

Davis PG, Schmidt B, Roberts RS, Doyle LW, Asztalos E, Haslam R, Sinha S, Tin W for the Caffeine for Apnea of Prematurity Trial Group: Caffeine for Apnea of Prematurity Trial: Benefits may vary in subgroups. J Pediatr. 2010 Mar;156(3):382-7. Epub 2009 Nov 18. Read the abstract

2009

Posencheg MA, Gow AJ, Ballard PL, Merrill JD, Ischiropoulos H, Truog WE, Cnaan A, Luan X, Golombek SG, Parton LA, Ballard RA. Effect of inhaled nitric oxide in premature infants on tracheal aspirate and plasma nitric oxide metabolites. Journal of Perinatology. 2010 Apr;30(4):275-80. Epub 2009 Oct 8. Read the abstract

Bassler D, Stoll B, Schmidt B, Asztalos E, Roberts RS, Robertson C, Sauve R. Using a count of neonatal morbidities to predict poor outcome in extremely low birth weight infants: Added role of neonatal infection. Pediatrics. 2009;123:313-318. Read the abstract

Armbruster J, Schmidt B, Poets CF, Bassler D. Nurses’ compliance with alarm limits for pulse oximetry: qualitative study. J Perinatol 2009 Epub 2009 December 10. Read the abstract

Garland JS, Alex CP, Uhing MR, Peterside IE, Rentz A, Harris MC. Pilot trial to compare tolerance of chlorhexidine gluconate to povidone-iodine antisepsis for central venous catheter placement in neonates. J  Perinatol. 2009 Dec;29(12):808-13. Epub 2009 Oct 8. Read the abstract

Williams C, Cairnie J, Fines V, Patey C, Schwarzer K, Aylward J, Lohfeld L, Kirpalani H. Construction of a parent-derived questionnaire to measure end-of-life care in the Neonatal Intensive Care Unit. Pediatrics. 2009;123(1):e87-95. Read the abstract

Whyte RK, Kirpalani H, Asztalos EV, Andersen C, Blajchman M , Heddle N, Lacorte M, Robertson CMT, Clarke MC, Vincer MJ, Doyle LW, Roberts RS, For The Pintos Study Group. Neurodevelopmental outcome of extremely low birth weight infants randomly assigned to restrictive or liberal hemoglobin thresholds for blood transfusion. Pediatrics. 2009;123(1):207-13. Read the abstract

Vanderveen JA, Bassler D, Robertson CM, Kirpalani H. Early interventions involving parents to improve neurodevelopmental outcomes of premature infants: a meta-analysis. J Perinatol.2009 May;29(5):343-51. Epub 2009 Jan 15. Read the abstract

Briel M, Lane M, Montori VM, Bassler D, Glasziou P, Malaga G, Akl EA, Ferreira-Gonzalez I, Alonso-Coello P, Urrutia G, Kunz R, Ruiz Culebro C, Alves da Silva S, Flynn DN, Elamin MB, Strahm B, Murad MH, Djulbegovic B, Adhikari NK, Mills EJ, Gwadry-Sridhar F, Kirpalani H, Soares HP, Abu Elnour NO, You JJ, Karanicolas PJ, Bucher HC, Lampropulos JF, Nordmann AJ, Burns KE, Mulla SM, Raatz H, Sood A, Kaur J, Bankhead CR, Mullan RJ, Nerenberg KA, Vandvik PO, Coto-Yglesias F, Schunemann H, Tuche F, Chrispim PP, Cook DJ, Lutz K, Ribic CM, Vale N, Erwin PJ, Perera R, Zhou Q, Heels-Ansdell D, Ramsay T, Walter SD, Guyatt GH. Stopping randomized trials early for benefit: a protocol of the Study Of Trial Policy Of Interim Truncation-2 (STOPIT-2). Trials. 2009 Jul 6;10(1):49. Read the abstract

Keene S, Munson D. Chapter 10-Delivery Room.  Now what?  In: Shah S, Frank G, editors. Patient Encounters in Pediatrics, Lippincott Williams and Wilkins.  2009.

Munson D, Feudtner C. The ethics of perinatal palliative care. In: Ravitsky V, Fiester A, Caplan AL, editors.  The Penn Center Guide to Bioethics. Springer: New York, 2009.

Kolla V, Gonzales LW, Bailey NA, Wang P, Angampalli S, Godinez MH, Muniswamy M, Ballard PL. Carcinoembryonic Cell Adhesion Molecule 6 (CEACAM6) in human lung: regulated expression of a multifunctional type II cell protein. Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L1019-30. Epub 2009 Mar 27. Read the abstract

Romer D, Betancourt LM, Giannetta JM, Brodsky NL, Farah MJ, Hurt H. Executive cognitive functions and impulsivity as correlates of risk taking and problem behavior in preadolescents. Neuropsychologia. 2009 Nov;47(13):2916-26. Epub 2009 Jun 26. Read the abstract

Rao H, Betancourt L, Giannetta JM, Brodsky NL, Korczykowski M, Avants BB, Gee JC, Wang J, Hurt H, Detre JA, Farah MJ. Early parental care is important for hippocampal maturation: evidence from brain morphology in humans. NeuroImage. 2010 Jan 1;49(1):1144-50. Epub 2009 Jul 9. Read the abstract

Hurt H, Betancourt LM, Malmud EK, Shera, DM, Giannetta JM, Brodsky NL, Farah MJ. Children with and without gestational cocaine exposure: A neurocognitive systems analysis. Neurotoxicol Teratol. 2009; 31:334-341.  Read the abstract

Suaud L, Miller K, Alvey L, Yan W, Robay A, Guttentag S, Hubbard M, Rubenstein R. ERp29 restricts Connexin43 oligomerization in the endoplasmic reticulum Mol Biol Cell. 2009 May;20(10):2593-604. Epub 2009 Mar 25. Read the abstract

Quinn GE, Evans J. Improving safety for babies during outpatient retinopathy of prematurity examination. J2009 Oct;13(5):429. Epub 2009 Aug 22. Read the abstract

Ades AM, Dominguez TE, Nicolson SC, Gaynor JW, Spray TL, Wernovsky G, Tabbutt S. Morbidity and mortality after surgery for congenital heart disease in the infant born with low weight. Cardiol Young. 2010 Feb;20(1):8-17. Epub 2009 Dec 18. Read the abstract

Sirajuddin AM, Osheroff JA, Sittig DF, Chuo J, Velasco F, Collins DA. Implementation pearls from a new guidebook on improving medication use and outcomes with clinical decision support. Effective CDS is essential for addressing healthcare performance improvement imperatives. J Healthc Inf Manag. 2009 Fall;23(4):38-45. Read the abstract 

Kassovska-Bratinova S, Yang G, Igarashi K, Dennery PA. Bach-1 modulates heme oxygenase-1 expression in the neonatal mouse lung. Pediatr Res. 2009 Feb;65(2):145-9.  Read the abstract

Wright CJ, Dennery PA. Manipulation of gene expression by oxygen: a primer from bedside to bench. Pediatr Res. 2009 Jul;66(1):3-10. Review.  Read the abstract

La P, Fernando AP, Zhuang T, Salahudeen A, Yang G, Lin Q, Wright CJ, Dennery, PA. Zinc protoporphyrin regulates cyclin D1 expression independent of heme oxygenase inhibition. J Biol Chem. 2009 Dec 25;284(52):36302-11. Epub 2009 Oct 22.  Read the abstract

Brion L, Neu J, Adamkin D, Bancalari E, Cummings J, Guttentag S, Juul S, Norwood V, Ryan R. Resident duty hour restrictions: Is less really more? J Pediatr. 2009 May;154(5):631-632.e1. Read the abstract

Kotorashvilli A, Russo S, Mulugeta S, Guttentag S, Beers M. Anterograde transport of surfactant protein C proprotein to distal processing compartments requires PPDY mediated association with Nedd4-2 ubiquitin ligases. J Biol Chem. 2009 Jun 12;284(24):16667-78. Read the abstract

Kilpatrick L, Harris MC. Cytokines and inflammatory response in the fetus and neonate. In: Polin RA, Fox WW, Abman SH, editors. Fetal and Neonatal Physiology, 4th Edition.  Elsevier, Inc., forthcoming, 2009.

Buckley EM, Cook NM, Durduran T, Kim MN, Zhou C, Choe R, Yu G, Shultz S, Sehgal CM, Licht DJ, Arger PH, Putt ME, Hurt H, Yodh AG. Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound. Optics Express. 2009 Jul 20; 17(15) 12571-81. Read the abstract 

Zhang H, Garber SJ, Cui Z, Foley JP, Mohan GS, Jobanputra M, Kaplan F, Sweezey NB, Gonzales LW, Savani RC. The angiogenic factor midkine is regulated by dexamethasone and retinoic acid during alveolarization and in alveolar epithelial cells. Respir Res. 2009 Aug 21;10:77. Read the abstract

2008

Reise K, Monkman S, Kirpalani H. The use of the Laerdal infant resuscitator results in the delivery of high oxygen fractions in the absence of a blender. Resuscitation. 2009 Jan;80(1):120-5. Epub 2008 Oct 25. Read the abstract

Farah M, Betancourt L, Shera D, Savage J, Giannetta J, Brodsky N, et al. Environmental stimulation, parental nurturance and cognitive development in humans. Dev Sci 2008 Sept;11(5):793-801. Read the abstract

Hurt H, Giannetta JM, Bordsky NL, Shera D, Romer D. Gambling initiation in preadolescents. J Adolesc Health. 2008 Jul;43(1):91-3. Epub 2008 Apr 11. Read the abstract

Haupt S, Donhauser N, Chaipan C, Schuster P, Puffer B, Daniels RS, Greenough TC, Kirchhoff F, Schmidt B. CD4 Binding affinity determines HIV-1 induced plasmacytoid dendritic cell interferon alpha production. J Virol. 2008 Sep;82(17):8900-5. Epub 2008 Jun 25. Read the abstract

Weiner DJ, McDonough J, Perez M, Evans J, Fox W, Hedgman A, Tyler L, Panitch HB. Heated, humidified high-flow nasal cannula therapy. Pediatrics. 2008 Jun;121(6):1293-4; author reply 1294.

Schmidt B, Roberts R, Millar D, Kirpalani H. Evidence-based neonatal drug therapy for prevention for prevention of bronchopulmonary dysplasia in very-low-birth-weight infants. Neonatology. 2008;93(4):284-7. Epub 2008 Jun 5. Read the abstract

Park JH, Stoffers DA, Nicholls RD, Simmons RA. Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1. J Clin Invest. 2008 Jun;118(6):2316-24. Read the abstract

Tan CC, Sindhu KV, Li S, Nishio H, Stoller JZ, Oishi K, Puttreddy S, Lee TJ, Epstein JA, Walsh MJ, Gelb BD.Transcription factor Ap2delta associates with Ash2l and ALR, a trithorax family histone methyltransferase, to activate Hoxc8 transcription. Proc Natl Acad Sci USA. 2008 May 27;105(21):7472-7. Epub 2008 May 21. Read the abstract

Williams C, Munson D, Zupancic J, Kirpalani H. Supporting bereaved parents: practical steps in providing compassionate perinatal and neonatal end-of-life care - A North American perspective. Semin Fetal Neonatal Med. 2008 Oct;13(5):335-40. Epub 2008 May 12. Read the abstract

Stoller JZ, Degenhardt KR, Huang L, Zhou DD, Lu MM, Epstein JA. Cre reporter mouse expressing a nuclear localized fusion of GFP and beta-galactosidase reveals new derivatives of Pax3-expressing precursors. Genesis. 2008 Apr;46(4):200-4. Read the abstract

Ballard PL, Truog WE, Merrill JD, Gow A, Posencheg M, Golombek SG, Parton LA, Luan X, Cnaan A, Ballard RA. Plasma biomarkers of oxidative stress: relationship to lung disease and inhaled nitric oxide therapy in premature infants. Pediatrics. 2008 Mar;121(3):555-61. Read the abstract

Maus MV, Posencheg MA, Geddes K, Elkan M, Peñaranda S, Oberste MS, Hodinka RL. Detection of echovirus 18 in human breast milk. J Clin Microbiol. 2008 Mar;46(3):1137-40. Epub 2008 Jan 16. Read the abstract

Gerson KD, Foster CD, Zhang P, Zhang Z, Rosenblatt MM, Guttentag SH. Pepsinogen C proteolytic processing of surfactant protein B. J Biol Chem. 2008 Apr 18;283(16):10330-8. Epub 2008 Feb 5. Read the abstract

Kirpalani H, Nahmias C. Radiation risk to children from computed tomography. Pediatrics. 2008 Feb;121(2):449-50. No abstract available.

DeMauro S, Crowley M, Kirpalani H.  We’re home – now what? Home oxygen therapy for newborns presents more questions than answers. Advance for Managers of Respiratory Care 17(9): 17-18, 2008.

Wright CJ, Posencheg MA. Newborn Jaundice, Schwartz’s Clinical Handbook of Pediatrics, 4th Edition, 2009, Chapter 46, pp. 525-545.

Bastek JA, Sammel MD, Pare E, Srinivas SK, Posencheg MA, Elovitz MA. Adverse neonatal outcomes: examining the risks between preterm, late preterm and term infants. American Journal of Obstetrics and Gynecology, 2008 Oct;199(4):367.e1-8. Read the abstract

Hutchison JS, Ward RE, Lacroix J, Hébert PC, Barnes MA, Bohn DJ, Dirks PB, Doucette S, Ferguson D, Gottesman R, Joffe AR, Kirpalani HM, Meyer PG, Morris KP, Moher D, Singh RM, Skippen PW for the Hypothermia Pediatric Head Injury Trial investigators and the Canadian Critical Care Trials Group. Hypothermia Therapy Following Traumatic Brain Injury in Children. N Engl J Med. 2008 June5;358(23):2447-56. Read the abstract 

Schmidt B, Roberts R, Millar D, Kirpalani H. Evidence-based neonatal drug therapy for prevention of bronchopulmonary dysplasia in very low birth weight infants. Neonatology. 2008;93(4):284-7. Epub 2008 June 5. Read the abstract 

Hutzal CE, Boyle EM, Kenyon SL, Nash JV, Winsor S, Taylor DJ, Kirpalani H. Use of antibiotics for the treatment of preterm parturition and prevention of neonatal morbidity: a metaanalysis. Am J Obstet Gynecol. 2008 Dec;199(6):620.e1-8. Epub 2008 Oct 30. Read the abstract 

Chuo J, Hicks R. Computer-related medication errors in neonatal intensive care units. Clin Perinatol. 2008 Mar;35(1):119-39, ix. Read the abstract

Genel M, McCaffree MA, Hendricks K, Dennery PA, Hay WW, Stanton B, Szilagyi, PC, Jenkins RR. A national agenda for America’s children and adolescents in 2008: recommendations from the 15th Annual Public Policy Plenary Symposium, Annual meeting of the Pediatric Societies, May 3, 2008.Pediatrics. 2008 Oct;122(4):843-9. PMID 18829810. No abstract available.

Wright CJ, Zhuang T, La P, Yang G, Dennery PA. Hyperoxia-induced NF-kB activation occurs via a maturationally sensitive atypical pathway. Am J Physiol Lung Cell Mol Physiol. 2009 Mar;296(3):L296-306. Epub 2008 Dec 12. Read the abstract

Hamvas A, Heins H, Guttentag S, Wegner D, Trusgnich M, Bennet K, Yang P, Carlson C, An P, Cole FS. Developmental and genetic regulation of human surfactant protein-B In vivo. Neonatology. 2009;95(2):117-24. Epub 2008 Sep 6. Read the abstract

Guttentag, S. Post-translational regulation of surfactant protein B expression. Semin Perinatol. 2008 Oct;32(5):367-70. Read the abstract

Feudtner C, Munson D, Morrison W. Framing permission for halting or continuing life-extending therapies. Virtual Mentor. 2008;10(8):506-510.

AlFaleh K, Smyth J, Roberts R, Solimano A, Asztalos E, Schmidt B, for the Trial of Indomethacin Prophylaxis in Preterms Investigators. Prevention and 18-Month outcomes of serious pulmonary hemorrhage in extremely-low-birth-weight infants: Results from the Trial of Indomethacin Prophylaxis in Preterms. Pediatrics. 2008;121;e233-e238. Read the abstract

2007

Lin Q, Weis S, Yang G, Zhuang T, Abate A, Dennery PA. Catalytic inactive heme oxygenase-1 protein regulates its own expression in oxidative stress. Free Rad Biol Med. 2008 Mar 1;44(5):847-55. Epub 2007 Dec 4. Read the abstract

Kooli A, Kermorvant-Duchemin E, Sennlaub F, Bossolasco M, Hou X, Honoré JC, Dennery PA, et al. Trans-Arachidonic acids induce a heme oxygenase-dependent vasorelaxation of cerebral microvasculature. Free Rad Biol Med. 2008 Mar 1;44(5):815-25. Epub 2007 Nov 28. Read the abstract

Cohen-Wolkowiez M, Benjamin DK Jr, Fowler VG Jr, Wade KC, Alexander BD, Worley G, Goldstein RF, Smith PB. Mortality and neurodevelopmental outcome after Staphylococcus aureus bacteremia in infants. Pediatr Infect Dis J. 2007 Dec;26(12):1159-61.

Rao H, Wang JJ, Giannetta J, Korczkowski M, Shera D, Avants BB, et al. Altered resting cerebral blood flow in adolescents with in-utero cocaine exposure revealed by perfusion functional magnetic resonance imaging. Pediatrics 2007 Nov; 120(5):e1245-54.

Ford, S, Farah MS, Shera DM, Hurt H. Neurocognitive correlates of problem behavior in environmentally at-risk adolescents. J Dev Behav Pediatr Oct; 28(5):376-85.

Avants BB, Hurt H, Giannetta JM, Epstein CL, Shera DM, Rao H, et al. Effects of heavy in utero cocaine exposure on adolescent caudate morphology. Pediatr Neurol 2007 Oct: 37(4):275-79.

Lorch SA, Wade KC, Bakewell-Sachs S, Medoff-Cooper B, Escobar GJ, Silber JH. Racial differences in the use of respiratory medications in premature infants after discharge from the neonatal intensive care unit. J Pediatr. 2007 Dec;151(6):604-10, 610.e1. Epub 2007 Aug 24.

Kirpalani H, Barks J, Thorlund K, Guyatt G. Cooling for neonatal hypoxic ischemic encephalopathy: do we have the answer? Pediatrics. 2007 Nov;120(5):1126-30. Review. No abstract available.

Hurt H, Giannetta JM, Korczykowski M, Hoang A, Tang KZ, Betancourt L, Brodsky NL, Shera DM, Farah MJ, Detre JA. Functional magnetic resonance imaging and working memory in adolescents with gestational cocaine exposure. J Pediatr. 2008 Mar;152(3):371-7. Epub 2007 Nov 5.

Bassler D, Ferreira-Gonzalez I, Briel M, Cook DJ, Devereaux PJ, Heels-Ansdell D, Kirpalani H, Meade MO, Montori VM, Rozenberg A, Schünemann HJ, Guyatt GH. Systematic reviewers neglect bias that results from trials stopped early for benefit. J Clin Epidemiol. 2007 Sep;60(9):869-73. Epub 2007 Apr 11. Review.

Dennery PA. Effects of oxidative stress on embryonic development. Birth Defects Res C Embryo Today. 2007 Sep;81(3):155-62. Review. Read the abstract

Cheong N, Zhang H, Madesh M, Zhao M, Yu K, Dodia C, Fisher AB, Savani RC, Shuman H. ABCA3 is critical for lamellar body biogenesis in vivo. J Biol Chem. 2007 Aug 17;282(33):23811-7. Epub 2007 May 31.

Lin Q, Weis S, Yang G, Weng YH, Helston R, Rish K, Smith A, Bordner J, Polte T, Gaunitz F, Dennery PA. Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress. J Biol Chem. 2007 Jul 13;282(28):20621-33. Epub 2007 Apr 12.

Dennery PA, Lorch S. Neonatal blue-light phototherapy could increase the risk of dysplastic nevus development. Pediatrics. 2007 Jul;120(1):247-8. No abstract available. PMID: 17606593

Watterberg KL, Shaffer ML, Mishefske MJ, Leach CL, Mammel MC, Couser RJ, et al. Growth and neurodevelopmental outcomes after early low -dose hydrocortisone treatment in extremely low birth weight infants. Pediatrics. 2007 Jul;120(1):40-8.

Simmons RA. Role of metabolic programming in the pathogenesis of beta-cell failure in postnatal life. Rev Endocr Metab Disord. 2007 Jun;8(2):95-104. Review.

Simmons RA. Developmental origins of beta-cell failure in type 2 diabetes: the role of epigenetic mechanisms. Pediatr Res. 2007 May;61(5 Pt 2):64R-67R. Review.

Alvira CM, Abate A, Yang G, Dennery PA, Rabinovitch M. Nuclear factor-kappaB activation in neonatal mouse lung protects against lipopolysaccharide-induced inflammation. Am J Respir Crit Care Med. 2007 Apr 15;175(8):805-15. Epub 2007 Jan 25.

Foster CD, Varghese LS, Skalina RB, Gonzales LW, Guttentag SH. In vitro transdifferentiation of human fetal type II cells toward a type I-like cell. Pediatr Res. 2007 Apr;61(4):404-9.

Konduri GG, Vohr B, Robertson C, Sokol GM, Solimano A, Singer J, Ehrenkranz RA, Singhal N, Wright LL, Van Meurs K, Stork E, Kirpalani H, Peliowski A, Johnson Y; Neonatal Inhaled Nitric Oxide Study Group. Early inhaled nitric oxide therapy for term and near-term newborn infants with hypoxic respiratory failure: neurodevelopmental follow-up. J Pediatr. 2007 Mar;150(3):235-40, 240.e1.

Simmons RA. Developmental origins of diabetes: the role of epigenetic mechanisms. Curr Opin Endocrinol Diabetes Obes. 2007 Feb;14(1):13-6. Review.