Neonatology Research
The Children's Hospital of Philadelphia is a leader in the advancement of basic and clinical research. We have one of the nation's largest pediatric research programs, spanning virtually every area of pediatric medicine. The knowledge that is gained from our studies has led and will continue to lead to improved healthcare for children worldwide.
Our clinical and basic research activities are conducted through the Children's Hospital of Philadelphia Research Institute. The Institute oversees the work of more than 150 investigators and their staffs who are pursuing hundreds of active research projects at any given time. Children's Hospital ranks among the top two pediatric hospitals nationwide in funding from the National Institutes of Health.
Our current areas of research in neonatology-related topics include:
Pulmonary
- Fetal lung development
- Lung antioxidant defenses
- Lung disease in premature infants
- Congenital diaphragmatic hernia and complex lung lesions
- Role of inflammation in lung disease
- Pulmonary function testing in the neonate
- Hormone regulation of fetal lung development
- Use of inhaled nitric oxide in premature infants
- Hormone regulation of fetal lung development
- The role and regulation of heme oxygenase in lung antioxidant defenses
Neurology
- Effect of inflammation and oxidative stress on the neonatal brain
- Neuroimaging and neurodevelopmental outcomes
- Biomarkers and neonatal brain injury
- Management of myelomeningocele (the most severe form of spina bifida)
- Maternal drug use and neonatal neurodevelopmental outcomes
Genetics
- Oxidative stress mediated gene regulation
- Fetal origins of adult disease
- Surfactant protein processing and physiology
- Biological chemistry and molecular mechanisms of action in nitric oxide
- Intrauterine growth retardation and insulin resistance
- Effect of maternal obesity on the fetus
- Mitochondrial biology
- Biomarkers of neonatal sepsis
- Serum biomarkers in necrotizing enterocolitis
- Neonatal pharmacokinetics
- Cell motility and proliferation; process of inflammation and fibrosis following tissue injury
- Surfactant protein processing and physiology
- Surfactant clinical trials — booster prophylaxis and rescue therapy
Cardiac
- Development of the conotruncal region of the heart
General
- Neonatal health services research
- Impact of neonatal outreach on referral patterns
- Multicenter trials to assess safety and efficacy of neonatal therapies
- Simulation strategies for neonatal education
- Community satisfaction of neonatal Level 4 care
Researchers and publications
For more information about neonatology research at CHOP, use the links below.
- View a selected list of current clinical studies.
- Meet our neonatology researchers.
- View selected neonatal research publications.
Updated April 2012
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