Clinical Studies
This list features selected current clinical studies by investigators in the Division of Neonatology.
Diffuse correlation spectroscopy for measurement of cerebral blood flow in preterm infants
In this study, investigators are using a novel optical imaging technique to investigate cerebrovascular autoregulation in preterm infants.
Pain assessment in the neonate
The purpose of this study is to identify objective, measurable parameters that indicate procedural pain in term infants, and that may be used as a future pain-assessment tool.
The impact of bacterial PCR and CSF cytokine levels on the diagnosis of bacterial meningitis in infants
The purpose of this study is to compare the results of conventional culture methods with a broad range 16S rRNA PCR assay followed by DNA sequencing to detect bacteria in the CSF. Investigators hypothesize that meningitis is under-diagnosed in infants. They expect that the PCR test will identify the causative organism more often than conventional cultures, particularly in the face of prior antibiotic administration.
Cross-sectional Pilot study of biologic samples in Necrotizing Enterocolitis: Proteomics and genomics approach
The purpose of this multicenter collaborative study is to determine whether there are specific genes or proteins in blood or urine that may predispose or identify infants with NEC. Investigators hope that these studies will enhance our ability to identify infants at highest risk of NEC and developing progressive disease.
Blood culture volume and time to positivity in suspected neonatal sepsis: presenting symptoms, risk factors, and outcomes
The goal of this prospective study is to examine the differences in time to positivity in association with culture volume as a method for evaluating blood stream infections among infants with suspected sepsis and to determine which presenting features and risk factors are most commonly associated with blood stream infections.
Multiple dose pharmacokinetic study of Meropenem in young infants
The purpose of this study is to determine the best dose and the safety of meropenem for the treatment of abdominal infections in infants more than 3 months of age. The study will evaluate 200 infants in over approximately 22 centers across the country.
In utero cocaine exposure: adolescent and young adult neurocognitive outcome
This study explores neurocognitive outcome, brain structure, response to stress and risk behaviors in African-American inner-city adolescents and young adults, half with gestational cocaine exposure and half without.
Adolescent drug use: exploring neurocognitive precursors
The long-term objectives of this research are reduction of substance use disorders through an improved understanding of the precursors of early initiation of substance us by adolescents.
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