Hereditary paraganglioma-pheochromocytoma syndrome (PGL/PCC) is a group of familial cancer syndromes characterized by the presence of:
Hereditary paraganglioma-pheochromocytoma (PGL-PCC) syndrome is diagnosed by the presence of certain clinical signs, a family history that shows the presence of PGL-PCC, and genetic testing that confirms the gene mutation.
The primary risk in hereditary PGL/PCC is the development of paragangliomas and pheochromocytomas. While the majority of these tumors are benign, in certain cases they may be malignant and thus more likely to spread to other parts of the body.
Organizations exist to support children and adults with paraganglioma-pheochromoctyoma syndrome, and the National Library of Medicine provides reliable information in Gene Reviews.