Hereditary Cancer Predisposition Program at the Cancer Center

Hereditary Paraganglioma-Pheochromocytoma (PGL/PCC) Syndrome

What is hereditary paraganglioma-pheochromocytoma syndrome?

Hereditary paraganglioma-pheochromocytoma syndrome (PGL/PCC) is a group of familial cancer syndromes characterized by the presence of:

Continue reading to learn about the subtypes of paragangliomas, typical symptoms, causes of paraganglioma-pheochromocytoma syndrome, and how the syndromes are inherited.

How is paraganglioma-pheochromocytoma syndrome diagnosed?

Hereditary paraganglioma-pheochromocytoma (PGL-PCC) syndrome is diagnosed by the presence of certain clinical signs, a family history that shows the presence of PGL-PCC, and genetic testing that confirms the gene mutation.

Continue reading to learn more about each of these diagnostic activities and reproductive options.

What cancer risks do people with paraganglioma-pheochromocytoma syndrome face and what cancer screenings are recommended for them?

The primary risk in hereditary PGL/PCC is the development of paragangliomas and pheochromocytomas. While the majority of these tumors are benign, in certain cases they may be malignant and thus more likely to spread to other parts of the body.

Continue reading to learn about the types of cancers that people with paraganglioma-pheochromoctyoma are at an increased risk to develop, and the cancer screenings recommended for them.

What resources are available for people with paraganglioma-pheochromocytoma syndrome?

Organizations exist to support children and adults with paraganglioma-pheochromoctyoma syndrome, and the National Library of Medicine provides reliable information in Gene Reviews.

Get more information.

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