Cancer Center

Pediatric Leukemia and Lymphoma Program

The leukemia and lymphoma treatment group at the Cancer Center at The Children's Hospital of Philadelphia offers children unrivalled access to disease experts who are also researchers with access to the most current research data to inform their clinical decisions.

The group is comprised of six pediatric oncologists who are nationally recognized for their expertise in the following cancers:

A unique treatment approach

In the clinical setting, each member of our pediatric leukemia and lymphoma group is intensively involved in all aspects of our patients' care planning, treatment and follow up. Our unique approach to care includes:

Our research

T cell therapy to treat ALL and other B cell cancers (CTL019)

CTL019, a clinical trial of T cell therapy for patients with B cell cancers such as acute lymphoblastic leukemia, B cell non-Hodgkin lymphoma (NHL), and the adult disease chronic lymphocytic leukemia (CLL), has shown exciting early results for the first patients to be treated.

This clinical trial, formerly referred to as CART19, uses immune cells taken from a patient's own blood, called T cells. These cells are genetically modified to express a protein which will recognize and bind to a target called CD19, which is found on cancerous B cells. Learn more about CTL019 »

Crizotinib targets ALK-driven cancers in pediatric trial

A phase 1 trial of the drug crizotinib achieved remissions, with minimal side effects, for 10 of the children participating in a clinical study carried out by the multicenter Children’s Oncology Group (COG). Some of these children had a diagnosis of anaplastic large cell lymphoma (ALCL). CHOP researcher Yael Mossé, MD, led the trial. Watch Dr. Mossé discuss this study, which was the result of nearly two decades of work by collaborating researchers, in the video below. Learn more about the trial »

Other research focuses

Our group has several areas of research focus but one that is shared by the entire group is the use of administrative data sets to answer research questions about patterns of illness and the relative effectiveness of various treatments. By studying large databases of information about disease incidence and treatment in hospitals, our researchers can gain insights that cannot be found by looking at data from a single institution.

Some other individual areas of research interest related to leukemia and lymphoma include:

See all clinical trials available at the Cancer Center.


To make an appointment or request a second opinion at the Cancer Center, please call 267-426-0762.

Learn more about second opinions at the Cancer Center.

Meet Our Team

Pediatric oncologists dedicated to treating leukemia and lymphoma


  • Print
  • Share

Contact Us

Existing patients or family members, please call


To schedule an initial appointment or request a 2nd opinion


Hope for a Child
with Lymphoma

When Zach’s lymphoma relapsed, his family felt helpless. But doctors at CHOP were optimistic about an experimental treatment that they believed could save the 5-year-old’s life. Read Zach's incredible story »

We’re #1 — again!

CHOP shares the top spot on U.S. News & World Report’s Honor Roll of the nation’s Best Children’s Hospitals. See why we’re still No. 1»