Pediatric Orthopaedics Translational Research Program
Researchers in the Translational Research Program in Pediatric Orthopaedics are investigating the mechanisms that control skeletal development and growth in fetal and postnatal life. The information and insights we gain through our biomedical research help us to understand the pathogenesis of congenital and acquired skeletal disorders such as multiple hereditary exostoses (MHE) and heterotopic ossification (HO).
Our 15-member team includes four faculty members, five post-doctoral fellows, a research associate, three research technicians, a graduate student and a program manager.
Areas of research interest
Dr. Maurizio Pacifici, director
Dr. Pacifici’s biomedical research focuses on the mechanisms that control skeletal development and growth and synovial joint formation in fetal and postnatal life, with an emphasis on identifying molecular regulators that are involved in the commitment, determination and differentiation of progenitor skeletal cells.
Dr. Massahiro Iwamoto
Dr. Iwamoto’s biomedical research centers on molecular mechanisms that control skeletal growth at the transcriptional and post-transcriptional level. He is interested in how information on these basic mechanisms could be used to stimulate cartilage and bone repair, and how aberrations in those mechanisms lead to acquired conditions such as heterotopic ossification.
Dr. Motomi Enomoto-Iwamoto
Dr. Enomoto-Iwamoto’s biomedical research focuses on cellular and signaling mechanisms including Wnt/ß-catenin signaling and how aberrations in those basic mechanisms lead to acquired and congenital conditions including osteoarthritis.
Dr. Eiki Koyama
Dr. Koyama’s biomedical research focuses on morphogenetic mechanisms that control limb and craniofacial skeletal formation and organization. He is interested in how these mechanisms could be used to stimulate tissue regeneration, and how changes in these mechanisms may cause congenital conditions such as hereditary multiple exostoses (HME) syndrome.
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