Hemifacial microsomia is a congenital condition in which the tissues on one side of the face are underdeveloped. It primarily affects the ear, mouth and jaw areas, though it may also involve the eye, cheek, neck and other parts of the skull, as well as nerves and soft tissue. In 10 to 15 percent of cases, both sides of the face are affected, often times asymmetrically.
Hemifacial microsomia is the second most common facial birth defect behind cleft lip and palate, affecting one in every 3,500 to 4,000 births. The condition is typically nonprogressive, meaning that the areas of the face that are affected at birth will typically remain similarly affected throughout growth and development, neither worsening nor getting better.
Hemifacial microsomia has many names, including: craniofacial microsomia, first and second branchial arch anomaly, branchial arch syndrome, facioauriculovertebral syndrome, oculoauriculovertebral spectrum, and lateral facial dysplasia.
Hemifacial microsomia is sometimes confused with Goldenhar syndrome, a rare congenital condition. In fact, hemifacial microsomia is just one of the distinctive characteristics of Goldenhar syndrome, which also includes spine anomalies and epibulbar dermoids or lipodermoids.
It is unclear what causes hemifacial microsomia. Research has shown the process starts in the first trimester of pregnancy and may be caused by a vascular problem leading to poor blood supply to the fetus’ face during early development. The facial anomalies are not triggered by a mother’s action or diet.
In the majority of cases, the condition is not inherited, and happens by chance. In a small minority of cases, a child may inherit the condition from his parents. An adult with hemifacial microsomia has about a 3 percent chance or less of having a child with the same condition.
Symptoms of hemifacial microsomia range from severe to barely noticeable and depend greatly on the degree of deformity and how much of the face is involved. A child with a mild form of hemifacial microsomia may have a slightly smaller jaw and a skin tag in front of a normal-looking ear. In more severe forms, a child’s face may appear much smaller on one side of his face, with an abnormally shaped or absent ear.
One of the ways clinicians describe and assess the severity of hemifacial microsomia is the OMENS classification. The OMENS classification examines the function and appearance of each of the following, looking for characteristics commonly associated with hemifacial microsomia:
Most children with hemifacial microsomia have facial anomalies but no other major medical issues. In some cases, babies born with hemifacial microsomia may also have other health problems such as malformed vertebrae, heart defects or abnormally shaped kidneys.
The diagnosis of hemifacial microsomia can be made before or after birth. Some of the abnormal facial features are visible during prenatal ultrasound. If you are pregnant and your unborn child has these distinctive characteristics, you may be referred to CHOP’s Center for Fetal Diagnosis and Treatment.
The majority of children are not diagnosed with hemifacial microsomia until after birth. In this case, experts from CHOP’s Craniofacial Program will evaluate your child. Experienced physicians will make the diagnosis based on your child’s appearance: the mandibular (jaw) deformity is the hallmark of hemifacial microsomia, and is classified based on the development of the jaw. In the mildest formation, the mandible is nearly normal and only slightly hypoplastic (underdeveloped), while in the most severe cases, a portion of the jaw is missing on the affected side.
Some of the facial characteristics of hemifacial microsomia mimic those seen in children with Treacher Collins syndrome; but hemifacial microsomia differences are typically one-sided or asymmetric, whereas in Treacher Collins, characteristics are similar on both sides of the face.
Diagnostic tests such as X-rays and CT scans may also be used to better examine your child’s bone and cartilage structure in order to make appropriate treatment recommendations.
The treatment of hemifacial microsomia varies tremendously from patient to patient and depends on the severity of the condition and long-term needs of the child. Consultation with an experienced craniofacial team is extremely important in achieving the best outcomes for your child.
At CHOP — where we have expertise in every pediatric specialty — your child will have access to a multidisciplinary healthcare team and coordinated care through our Craniofacial Program. We will work with you to prioritize your child’s needs and establish a comprehensive treatment plan that addresses both physical and psychosocial needs, including planning for staged surgical repair and reconstruction.
Timing can be a critical factor in treatment of hemifacial microsomia. In some cases, treatment can wait until your child reaches certain developmental milestones.
If your child is born with hemifacial microsomia, he may require respiratory support or a tracheostomy if the jaw is severely deficient. In most cases, your child’s airway can be managed conservatively.
Due to the presence of the jaw deformity and clefts, your child may experience feeding difficulties. He may receive supplemental feedings through a nasogastric tube to support his growth and weight gain.
If facial paralysis or eyelid abnormalities are present, eye closure may be incomplete and eye protection must be provided either via lubricants or surgical procedures.
As your child with hemifacial microsomia grows, he may need surgical treatment based on the severity and area affected. Not all children with hemifacial microsomia have problems in all of these areas.
Below are some of the interventions your child may need. If you have any questions about treatment for your child, please talk to your child’s healthcare team or call the Division of Plastic and Reconstructive Surgery at 215-590-2208.
As is the case for any patient with a complex craniofacial deformity, individual treatment varies depending upon the degree of involvement of the various structures. Your child’s individual treatment plan may vary from others similarly affected due to a variety of other factors. It is important that you see an experienced craniofacial team to manage and assess your child’s condition.
As your child with hemifacial microsomia grows into adolescence, he should continue to be monitored by experienced physicians who can adjust treatment plans as needed.
Because multiple body systems may be involved in hemifacial microsomia, continued monitoring for complications and any treatment as needed are important to optimal long-term outcomes.
CHOP’s Craniofacial Program brings together the many specialists your child may need to see, including:
During follow-up visits, diagnostic testing may be done. The goal of continued monitoring is to help spot any irregularities in growth or development and to address health issues as they develop, optimizing long-term outcomes for your child.
Follow-up care and ongoing support and services are available at our Main Campus and throughout our CHOP Care Network. Our team is committed to partnering with parents and referring physicians to provide the most current, comprehensive and specialized care possible for your child.
Treatment of hemifacial microsomia depends on the severity of the condition and long-term needs of the child. Consultation with an experienced craniofacial team is extremely important in achieving the best outcomes for your child.
At CHOP, children with hemifacial microsomia have access to the nation’s top pediatric specialists and coordinated care through our Craniofacial Program. Our team works closely with parents and referring physicians to addresses both physical and psychosocial needs associated with this condition, including surgical repair, feeding and breathing support, orthodontic needs, speech therapy and long-term follow-up care from any other related pediatric specialties depending on your child’s condition.
Reviewed by: Scott Bartlett, MD and Jesse Taylor, MD
Date: February 2014