Research
Current areas of investigation
- Neurohumoral, cellular and molecular mechanisms regulating airway contractility
- Airway smooth muscle growth and cell surface receptor expression
- Regulation of postnatal development and growth of the lung
- Developmental effects of pulmonary inflammation and oxidative lung injury on airway and pulmonary vascular reactivity
- Biochemical and molecular regulation of membrane ion channels and glycoprotein structure and function in cystic fibrosis
- CFTR gene trafficking
- Maturational changes in chest wall and airway function
- Pulmonary manifestations of sickle cell disease
- The physiological basis of ventilator dependence in children with chronic respiratory insufficiency
- Developmental aspects of respiratory mechanics and ventilatory control
Other areas of applied research
- Studies on airway reactivity in infants
- Evaluation of mechanisms of airway hyper-responsiveness in asthma
- Assessment of mechanisms of the sleep-disorders
- Pulmonary function abnormalities following lung transplantation
- Control of ventilation in lung disease
- Development of new tests of lung function in infants
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Protein Assist and Chloride Channel Therapies: Phenylbutyrate and Genistein