The Sleep Center

Research

Director

Carole L. Marcus, MBBCh

Dr. Marcus' research is focused on understanding the pathophysiology of childhood obstructive sleep apnea and the developmental aspects of ventilatory and upper airway control. Studies have concentrated on clinical research across the age spectrum, evaluating upper airway collapsibility during sleep, as well as arousal mechanisms. In addition, in concurrent studies she is evaluating other aspects of sleep-disordered breathing, including diagnostic techniques and treatment, with an emphasis on noninvasive ventilation.

Representative publications

Marcus CL, Fernandes Do Prado LB, Lutz J, Katz ES, Black CA, Galster P, Carson KA. Developmental changes in upper airway dynamics. J Appl Physiol 2004; 97:98-108.

Marcus CL, Katz ES, Lutz J, Black CA, Galster P, Carson KA. Upper airway dynamic responses in children with the obstructive sleep apnea syndrome. Pediatr Res 2005; 57:99-107.

Marcus CL. State of the art: sleep-disordered breathing in children. Am J Respir Crit Care Med 2001 Jul;164(1):16-30.

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Lee J. Brooks, MD

Dr. Brooks' research interests focus on the pathophysiology and effects of obstructive sleep apnea. He is currently working on a project to study the relationship between sleep apnea and diabetes, and a project with the elementary and middle schools of Voorhees, New Jersey to educate parents and teachers of the effects of sleep disorders on learning.

Representative publications

Brooks LJ, Topol HI. Enuresis in children with sleep apnea. J Pediatr. 2003 May;142(5):515-8.

Crowell DH, Kulp TD, Kapuniai LE, Hunt CE, Brooks, LJ, Weese-Mayer DE, Silvestri J, Ward SD, Corwin M, Tinsley L, Peucker N; CHIME Study Group. Infant polysomnography: reliability and validity of infant arousal assessment. J Clin Neurophysiol. 2002 Oct;19(5):469-83.

Topol HI, Brooks LJ. Follow up of primary snoring in children. J Pediatr. 2001 Feb;138(2):291-3.

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Thornton B.A. Mason, MD, PhD

Dr. Mason's research interests include genetic influences on sleep and sleep disorders. He has particular research interests in periodic limb movements in sleep (PLMS), and has received a mentored patient-oriented research career development award (K23), through the National Center for Research Resources of the National Institutes of Health, entitled "Periodic Limb Movements in Williams Syndrome". This special group of patients may represent a unique opportunity to allow identification of a gene(s) involved in PLMS. Other areas of interest include possible gene influences on Restless Legs Syndrome and parasomnias in childhood, particularly sleep terrors.

Representative publications

Raizen, D.M., Mason T.B.A., Pack A.I. Genetic basis for sleep regulation and sleep
Disorders. Seminars in Neurology 26: 467-483, 2006.

Mason, T.B.A., Pack A.I. Pediatric parasomnias. Sleep 30: 141-151, 2007.

Mason TB, Pack AI. Sleep terrors in childhood. J Pediatr. 2005 Sep;147(3):388-92.

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Associate director

Jodi A. Mindell, PhD

Dr. Mindell's research focuses on the assessment and non-pharmacologic treatment of sleep problems in infants and toddlers, as well as in special populations such as foster children and adoptive children. Furthermore, she is currently working on several project investigating the prescribing practices of pediatricians and child psychiatrists for sleep problems in children and adolescents.

Representative publications

Mindell, JA et al. Behavioral treatment of bedtime problems and night wakings in young children: AASM Standards of Practice. Sleep, 2006; 29:1263-1276.

Meltzer, LJ & Mindell, JA. Impact of a child's chronic illness on maternal sleep and daytime functioning. Archives of Internal Medicine, 2006;166:1749-1755.

Mindell, JA et al. Pharmacological management of insomnia in children and adolescents: A consensus statement. Pediatrics, 2006;117:1123-1232.

Mindell JA, Owens J. A Clinical Guide to Pediatric Sleep: Diagnosis and Management of Sleep Problems. Philadelphia: Lippincott Williams & Wilkins, 2003.

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Lisa J. Meltzer, PhD

Dr. Meltzer's research focuses on sleep in caregivers of children with chronic health conditions, including caregivers of ventilator-dependent children and children with autism. Additional research interests include the use of pharmacological interventions for sleep in hospitalized children, sleep in adolescents with chronic pain, and the measurement of sleep patterns and subjective sleep quality.

Representative publications

Meltzer, L. J., Logan, D.E., & Mindell, J.A. (2005). Sleep patterns in female adolescents with chronic musculoskeletal pain. Behavioral Sleep Medicine, 3(4), 193-208.

Meltzer, L. J. & Mindell, J.A. (2006). Impact of a child's chronic illness on maternal sleep and daytime functioning. Archives of Internal Medicine, 166, 1749-1755.

Meltzer, L. J. & Mindell, J. A. (2007). Relationship between child sleep disturbances and maternal sleep, mood, and stress. Journal of Family Psychology, 21(1), 67-73.

Meltzer, L. J., Mindell, J. A., Owens, J. A., Byars, K. C. (in press). The use of sleep medications in hospitalized pediatric patients. Pediatrics.

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