The Trisomy 21 Program

Upcoming Events

Check out our Upcoming Events page detailing new programs for Trisomy 21 families. We hope you'll join us!

Keep in Touch

Make sure you are getting all the updates from the Trisomy 21 Program. Update your contact information today.

The Trisomy 21 Program

Established in 2003, the Trisomy 21 Program at The Children's Hospital of Philadelphia assesses the developmental, behavioral and health needs of children and adults with Down syndrome (trisomy 21).

Our multidisciplinary team supports families by providing educational material, recommendations and ongoing treatment.

About your child's first appointment

Your child's first appointment in our clinic will focus on a thorough evaluation. We will:

Patients over the age of 18 are evaluated through the Division of Neurology and assessed from a neurological and social/vocational perspective. A full medical history and physical examination are performed to ensure that all recommended testing for individuals with Down syndrome have been addressed.

Social issues are managed as they arise and may include guidance on transitions to adulthood, employment, creative living options, sexuality and issues surrounding aging adults with Down syndrome. New neurological problems will be evaluated as they arise.

For more information, see organizing your child's care and resources for families.

Prenatal consultation

When families receive a prenatal diagnosis, our program can offer up-to-date information and resources. We are also available to meet with expectant parents to provide an opportunity to ask questions and gain knowledge about Down syndrome.

The care team

Our pediatric team consists of a developmental pediatrician, nurse practitioner, speech therapist, physical therapist, occupational therapist, and a social worker who can provide a comprehensive multidisciplinary approach to care.

Our adult team consists of a neurologist, nurse practitioner, physical therapist, and social worker who can offer quality care as well as transition guidance.

Additional consultations

The Trisomy 21 Program team has easy access to the many subspecialties at The Children's Hospital of Philadelphia. We will refer your child to them as needed, based upon our evaluation findings.


Our research efforts help us to better understand trisomy 21. Current studies focus on the biologic basis of trisomy 21, medical and neurodevelopmental consequences, and effective interventions. We will keep you abreast of any ongoing research that could benefit your child with Down syndrome. For further details, see our research.


To make an appointment, please call 267-426-5283.


For door-to-door directions to The Children's Hospital of Philadelphia, visit our directions page.

Date: December 2013

  • Print
  • Share

Contact Us

Cristin's Story

Cristin, 27, is one of the many adult patients cared for by the Trisomy 21 Program at CHOP.
Meet Cristin »

Support for Your Family

The Trisomy 21 Parent Peer Program provides social, emotional and informational support to families by matching them with a mentor. To learn more, download our brochure in English or Spanish.