Vaccine Education Center

A Look at Each Vaccine: Tuberculosis Vaccine

The tuberculosis (TB) vaccine is rarely used in the United States. It is only recommended for those children living with someone who is actively infected with TB and who either cannot take antibiotics to treat the infection or is infected with a strain of TB that is highly resistant to all antibiotics, and a select subset of healthcare workers. Decisions regarding this vaccine are typically made in consultation with a local TB control program. The TB vaccine is given as a single shot.

In most other countries, the vaccine for tuberculosis, known as the BCG vaccine, is used more commonly because of the frequency of tuberculosis.

The impact of tuberculosis

Tuberculosis kills more people in the world than any other infection. Each year about 9 million people are infected with TB and about 1.5 million die.

What is tuberculosis?

Tuberculosis (TB) is caused by a bacterium, Mycobacterium tuberculosis. The infection primarily attacks the lungs. The bacterium is so destructive that it is common to cough up both mucus and blood. Those less than 5 years old are susceptible to a very severe, often fatal, form of TB (called "miliary" TB) that spreads to many parts of the body, including the lining of the brain (meninges).

Extremely contagious, TB is spread through the simple act of sneezing, talking and coughing. Many people who are infected don't get sick right away; rather, the bacteria remains dormant, reactivating years, even decades, later. That's when lung disease and the characteristic cough begin.

A skin test (PPD) and chest X-ray are the best ways to tell if someone is infected with TB.

How is the tuberculosis vaccine made?

Known as BCG, the TB vaccine has been around since the early 1920s. It is made by weakening a strain of bacteria similar to tuberculosis that was first isolated in cows. This strain of bacteria, called Mycobacterium bovis, is similar enough to the human strain (Mycobacterium tuberculosis) that vaccination with the bovine strain protects against disease caused by the human strain.

Does the tuberculosis vaccine have side effects?

About three of every 10,000 people immunized with the tuberculosis vaccine develop a painful swelling under the arm.

Is the incidence of TB in the United States increasing?

The incidence of tuberculosis has been steadily increasing in the United States since 1985. Since 1985, there have been about 40,000 more cases of tuberculosis than would have been predicted from the incidence of the disease between 1950 and 1984. The single most important reason for this increase is the entrance of HIV into the United States. People with HIV have weakened immune systems, so they are more susceptible to other infections, including TB.

Since TB is increasing in the United States, why isn't the vaccine recommended for everyone at risk of catching the disease?

The TB vaccine is good at protecting against the severe form of disease found in young children (called "miliary" TB), but is not as good at protecting against the lung infection commonly found in adolescents and adults. Because miliary TB is very uncommon in the United States, we do not use the TB vaccine. The United States is one of only two countries that have never routinely used the TB vaccine (The Netherlands is the other).

Who should get the tuberculosis vaccine?

The tuberculosis vaccine is recommended only for those children living with someone with TB who either cannot take the antibiotics required to treat the infection or who is infected with a strain that is highly resistant to all antibiotics, and a select group of healthcare workers. Ultimately, only a small number of people in the United States fall into these categories.

If we are not routinely using the tuberculosis vaccine, what are we doing to stop the spread of tuberculosis in the United States?

The United States does two things to stop the spread of TB. First, people who are actively or silently infected with TB are identified by performing regular PPD tests. Second, once identified, people with TB are treated with one or more antibiotics that are effective against the bacteria: specifically, Isoniazid (or INH), Rifampin, Ethambutal or Pyrazinamide.

Do the benefits of the tuberculosis vaccine outweigh its risks?

The tuberculosis vaccine is not highly effective at preventing lung infections caused by the tuberculosis bacteria. For this reason, the vaccine is only recommended for a fairly uncommon subset of those in contact with someone infected with tuberculosis: specifically someone in constant contact with a person infected with TB who either refuses to take antibiotics or is infected with a strain that is resistant to all antibiotics. On the other hand, the tuberculosis vaccine has no serious side effects. Therefore, in the uncommon subset of people who should use the vaccine, the benefits clearly outweigh the risks.

Who?
A very small subset of children and healthcare workers
Disease Risks Vaccine Risks
  • Coughing up blood and mucus 
  • Antibiotics don’t always work
  • Can lead to miliary TB, particularly in children, spreading to other parts of the body including the meninges
  • Disease can be fatal
  • Painful, swelling under the arm (3 in 10,000 people) 
  • May not protect against more common type of tuberculosis 


Reference

Plotkin SA, Orenstein W, and Offit PA. Tuberculosis vaccines in Vaccines, 6th Edition, 2012, 789-811.
 

Reviewed by: Paul A. Offit, MD
Date: April 2013

Materials in this section are updated as new information becomes available. The Vaccine Education Center staff regularly reviews materials for accuracy.

You should not consider the information in this site to be specific, professional medical advice for your personal health or for your family's personal health. You should not use it to replace any relationship with a physician or other qualified healthcare professional. For medical concerns, including decisions about vaccinations, medications and other treatments, you should always consult your physician or, in serious cases, seek immediate assistance from emergency personnel.

 

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Tuberculosis Vaccine Q&A

"Tuberculosis : What you should know" Q&A sheet: