Several large studies have investigated the relationship between vaccines and allergies.
One well-controlled study was performed using the computerized records of children born between 1991 and 1997 who were enrolled in four large health maintenance organizations (HMOs). Researchers identified 18,407 children with asthma. The risk for asthma was not greater in children who received DTP vaccine, oral polio vaccine, MMR vaccine, Hib vaccine or hepatitis B vaccine compared with children who did not receive these vaccines.
Another large well-controlled study prospectively evaluated the risk of allergies following receipt of the pertussis vaccine in 669 children. Infants were randomized to receive one of three different diphtheria-tetanus-pertussis vaccines or a control vaccine that did not contain pertussis beginning at 2 months of age. Children were followed for about two and a half years and the risk of allergies was determined by parent questionnaires and examination of medical records. Allergic disorders studied included asthma, skin reactions, hay fever, hives and food allergies. No differences in the incidence of allergic diseases were observed in children who did or did not receive pertussis vaccine. Of interest, children with natural pertussis infections were more likely to develop allergic diseases than children not infected with pertussis.
Taken together, these studies fail to support the hypothesis that vaccines cause asthma or allergic diseases.
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Reviewed by: Paul A. Offit, MD
Date: April 2013
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