Dr. Barrett’s current efforts in conjunction with the mission of the Clinical Pharmacology and Therapeutics Division are focused on the investigation of sources of variation in pediatric pharmacokinetics and pharmacodynamics. Applied clinical pharmacologic investigation coupled with modeling and simulation strategies are pursued with the intention of developing rational dosing guidance in various pediatric populations for both marketed and exploratory compounds. Clinical trial simulation is to be utilized prospectively to explore design dependencies and parameter sensitivities. Dr. Barrett also directs the Laboratory for Applied PK/PD which is focused on the development of pharmacometric approaches to advance PK/PD, novel biomarker development and disease progression modeling.
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