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Unraveling the Mysteries of Hyperinsulinism Video Series
The Congenital Hyperinsulinism Center at The Children's Hospital of Philadelphia is the largest program of its kind in North America. Unraveling the Mysteries of Hyperinsulinism provides an overview of the groundbreaking work being done at CHOP to treat this disease.
Transcript: What We Know About Hyperinsulinism
Charles A. Stanley, MD: Prior to 1990, we thought that hyperinsulinism was caused by a developmental problem of the pancreas, which we used to call nesidioblastosis and we now recognize that there are these specific genetic diseases.
Lori Prinz Halaby, NP: With advances in research and technology we found that there are two different types of hyperinsulinism, focal and diffuse disease.
Charles A. Stanley, MD: The pancreas in a newborn baby is just about the size of my finger here. When there's diffuse disease all of the insulin secreting cells in the pancreas are abnormal, but when it's focal disease a very small cluster of cells, measuring perhaps less than a quarter of an inch in diameter, are abnormal.
N. Scott Adzick, MD: It became clear that the genetics between the two types could be delineated and eventually we were able to craft diagnostic means to differentiate the two groups and therapeutic means to be quite selective in the treatment of those babies with focal disease to simply excise completely the focal lesion and then preserve as much of the surrounding normal pancreas as possible.
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