You can get detailed driving directions to the Main Campus or any other Children's Hospital location from Google Maps.
From I-95 South, follow Exit 22 for I-676 West (Vine Street Expressway). Follow I-676 to exit for I-76 East, International Airport. Follow I-76 East to the University Ave. exit, 346B. Bear right on the ramp and proceed straight to the first traffic light at Civic Center Blvd. Turn right on Civic Center Blvd. For parking in the Wood Center garage, proceed to the second traffic light and turn left onto Osler Circle. For parking in the Main Hospital, continue on Civic Center Blvd. and make a left into the main parking garage.
Take the Pennsylvania Turnpike to Exit 326 (old exit 24), Valley Forge. Take I-76 East to Exit 346B, University Ave. Bear right on the ramp and proceed straight to the first traffic light at Civic Center Blvd. Turn right on Civic Center Blvd. For parking in the Wood Center garage, proceed to the second traffic light and turn left onto Osler Circle. For parking in the Main Hospital, continue on Civic Center Blvd. and make a left into the main parking garage.
Take I-476 South to Exit 20 (old exit 25A), Mid-County. After toll, continue south on I-476 to Exit 16A for I-76 East, Schuylkill Expressway-Philadelphia. Follow I-76 East to Exit 346B, University Ave. Bear right on the ramp and proceed straight to the first traffic light at Civic Center Blvd. Turn right on Civic Center Blvd. For parking in the Wood Center garage, proceed to the second traffic light and turn left onto Osler Circle. For parking in the Main Hospital, continue on Civic Center Blvd. and make a left into the main parking garage.
Take I-95 North to Exit 13, I-76 West - Valley Forge. Merge right to exit for Center City. Cross the bridge and turn left at the light to I-76 West. Follow I-76 West to Exit 346B, University Ave. At the bottom of the ramp proceed straight and go to the 5th traffic light, Civic Center Blvd. Turn right on Civic Center Blvd. For parking in the Wood Center garage, proceed to the second traffic light and turn left onto Osler Circle. For parking in the Main Hospital, continue on Civic Center Blvd. and make a left into the main parking garage.
Take the New Jersey Turnpike to Exit 3, then the Black Horse Pike (Rte. 168 North) for one mile to I-295 South. Go one mile to Exit 26 , I-76 West to the Walt Whitman Bridge. Cross the Bridge onto I-76 West (Schuylkill Expressway) to Exit 346B, University Ave. At the bottom of the ramp proceed straight and go to the 5th traffic light, Civic Center Blvd. Turn right on Civic Center Blvd. For parking in the Wood Center garage, proceed to the second traffic light and turn left onto Osler Circle. For parking in the Main Hospital, continue on Civic Center Blvd. and make a left into the main parking garage.
Take the Benjamin Franklin Bridge to 676 West (Vine St. Expressway). Follow I-676 to exit for I-76 East, International Airport. Take I-76 East to Exit 346B, University Ave. Bear right on the ramp and proceed straight to the first traffic light at Civic Center Blvd. Turn right on Civic Center Blvd. For parking in the Wood Center garage, proceed to the second traffic light and turn left onto Osler Circle. For parking in the Main Hospital, continue on Civic Center Blvd. and make a left into the main parking garage.
Take I-76 East to Exit 346B, University Ave. Bear right on the ramp and proceed straight to the first traffic light at Civic Center Blvd. Turn right on Civic Center Blvd. For parking in the Wood Center garage, proceed to the second traffic light and turn left onto Osler Circle. For parking in the Main Hospital, continue on Civic Center Blvd. and make a left into the main parking garage.
Travel east on Chestnut or Spruce St. to 34th St. Turn right onto 34th St. Parking for the Main Hospital is on your right, just past the entrance for the Hospital of the University of Pennsylvania. For parking in the Wood Center garage, continue past the Hospital and turn right onto Osler Circle, go straight at the stop sign, then right into garage.
Travel west on Market or Walnut St. to 34th St. Turn left on 34th St. and cross Spruce St. Parking for the Main Hospital is on your right, just past the entrance for the Hospital of the University of Pennsylvania. For parking in the Wood Center garage, continue past the Hospital and turn right onto Osler Circle, go straight at the stop sign, then right into garage.
Take Roosevelt Blvd. to I-76 East. Take I-76 East to Exit 346B, University Ave. Bear right on the ramp and proceed straight to the first traffic light at Civic Center Blvd. Turn right on Civic Center Blvd. For parking in the Wood Center garage, proceed to the second traffic light and turn left onto Osler Circle. For parking in the Main Hospital, continue on Civic Center Blvd. and make a left into the main parking garage.