Identifying Therapeutic Vulnerabilities of Pediatric Malignant Glioma and Embryonal Tumors

Research in the laboratory of Kristina A. Cole MD, PhD, involves identifying the proteins required for malignant gliomas with alternative lengthening of telomeres (ALT) to continue to proliferate. To do these studies the Cole laboratory is performing high-throughput screening of patient-derived cell lines derived from tumors from children with malignant glioma with and without ALT in collaboration with the multi-institution Children’s Brain Tumor Tissue Consortium and investigators at the University of Pennsylvania.

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