Alix Seif Laboratory
Ongoing Research
Researchers at the Center for Childhood Cancer Research have developed a unique mouse model system to develop new strategies that induce immune-mediated protection against ALL disease progression.
Researchers at the Center for Childhood Cancer Research are currently evaluating the use of antibody drug conjugates and targeted small molecule drugs as treatments for acute myeloid leukemia (AML) in a Phase III clinical trial.
Researchers are analyzing clinical samples and medical outcomes data from AML clinical trials to establish possible molecular links between specific AML germline or somatic mutations and disease progression and treatment responsiveness.
Researchers at the CCCR performed chart review for 12 different AEs for pediatric patients enrolled in U.S.-based COG Phase III clinical trials for pediatric acute myeloid leukemia (AML). Results from this analysis showed the current system of AE reporting on cooperative group oncology trials had modest sensitivity and a demonstrable false positive rate.
Researchers at the Center for Childhood Cancer Research are studying the ability of mitoxantrone and related agents to potentiate immune responses to pediatric ALL.
Researchers at the Center for Childhood Cancer Research are investigating new immunotherapies using chimeric antigen receptor (CAR)-modified T cells to treat children with relapsed and refractory AML.
Researchers at the Center for Childhood Cancer Research are investigating the use of immunostimulatory synthetic DNA oligonucleotides that contain CpG motifs (CpG ODNs) to induce anti-leukemia immune responses in pediatric ALL.