Carolyn A. Felix Laboratory

Led by Carolyn A. Felix MD, researchers in the Felix Laboratory are studying the molecular mechanisms underlying the formation of chromosomal translocations of the Mixed-Lineage Leukemia (MLL) gene and the effects of MLL translocations on the development of high-risk forms of leukemia that occur in infants and as a chemotherapy complication.

Research on Crucial Cutting Enzyme Maps DNA Damage in Leukemias

Selected Publications

Unique Familial MLL(KMT2A)-Rearranged Precursor B-Cell Infant Acute Lymphoblastic Leukemia in Non-twin Siblings. Pediatr Blood Cancer. 2016 Jul;63(7):1175-80. doi: 10.1002/pbc.25957. Epub 2016 Mar 21. PMID: 26999444.
Urtishak KA, Robinson BW, Rappaport EF, Sarezky MD, Biegel JA, Nichols KE, Wilmoth DM, Wang LS, Stern JW, Felix CA.

Inhibiting cytosolic translation and autophagy improves health in mitochondrial disease. Hum Mol Genet. 2015 Sep 1;24(17):4829-47.
Peng M, Ostrovsky J, Kwon YJ, Polyak E, Licata J, Tsukikawa M, Marty E, Thomas J, Felix CA, Xiao R, Zhang Z, Gasser DL, Argon Y, Falk MJ.

Intensified chemotherapy without SCT in infant ALL: results from COG P9407 (Cohort 3). Pediatr Blood Cancer. 2015 Mar;62(3):419-26.
Dreyer ZE, Hilden JM, Jones TL, Devidas M, Winick NJ, Willman CL, Harvey RC, Chen IM, Behm FG, Pullen J, Wood BL, Carroll AJ, Heerema NA, Felix CA, Robinson B, Reaman GH, Salzer WL, Hunger SP, Carroll WL, Camitta BM.