Craig Bassing Laboratory

Ongoing Research

Development of a Transgenic Mouse Model to Study Aggressive Pediatric B- and T-cell Lymphomas with Tp53 Inactivation

Researchers at the Center for Childhood Cancer Research are using a transgenic mouse model to demonstrate that somatic inactivation of Tp53 predisposed mice to thymic lymphomas with translocations.

The Role of T-cell Receptor (TCR) Germline Translocations in a ATM-/- Transgenic Mouse Model of Pediatric T-cell Acute Lymphoblastic Leukemia (T-ALL)

Researchers at the Center for Childhood Cancer Research have developed an ATM-/- deficient-transgenic mouse model to study the effect of germline TCR gene translocations on the development of T-ALL.