Jennifer Kalish Laboratory

Ongoing Research

Researchers are identifying pathways promoting the preterm birth of BWS children using combinational approaches, using placental samples and IPSC modeling.

Researchers are trying to understand the connections between BWS-driven liver growth and changes in the metabolic signaling, using patient biopsies, organoid models, and engineered IPSCs.

Researchers are querying which cell types are contributing to macroglossia in BWS, as well as which internal and external signaling pathways are promoting tongue overgrowth.

Researchers at the Center for Childhood Cancer Research are studying the genetic and epigenetic mechanisms that contribute to the increased risk of children with Beckwith-Wiedemann syndrome (BWS) to develop cancer.

Researchers at the Center for Childhood Cancer Research are working to generate a series of position papers intended to detail the recommended best practices for pediatric cancer surveillance.

Researchers are examining BWS kidneys, using single-cell sequencing technologies, patient biopsies, and IPSC modeling to identify dysregulated pathways that may be targeted in future studies.

Researchers are studying the underlying cellular and molecular mechanisms that contribute to the epigenetic mosaicism characteristic of patients with human imprinting disorders including Beckwith-Wiedemann syndrome (BWS) and Russell-Silver syndrome (RSS).