Kristina Cole Laboratory

Kristina Cole, MD, PhD is a pediatric oncologist who has dedicated her career to translational and clinical research, combining her expertise in molecular pathology, cancer genomics, and developmental therapeutics to identify novel treatments for children with cancer. The long-term goal of Dr. Cole’s research team and collaborators is to identify effective therapies and improve the cure rate of children with malignant brain tumors.

Selected Publications

Pediatric High Grade Glioma Resources from the Children's Brain Tumor Tissue Consortium (CBTTC). Neuro Oncol 2019 Oct 15. PMID: 31613963.
Ijaz H, Koptyra M, Gaonkar KS, Rokita JL, Baubet VP, Tauhid L, Zhu Y, Brown M, Lopez G, Zhang B, Diskin SJ, Vaksman Z, Mason JL, Appert E, Lilly J, Lulla R, De Raedt T, Heath AP, Felmeister A, Raman P, Nazarian J, Santi MR, Storm PB, Resnick A, Waanders AJ, Cole KA; Children’s Brain Tumor Tissue Consortium.

CASC15-S is a tumor suppressor lncRNA at the 6p22 neuroblastoma susceptibility locus. Cancer Res. 2015 Aug 1;75(15):3155-66.
Russell MR, Penikis A, Oldridge DA, Alvarez-Dominguez JR, McDaniel L, Diamond M, Padovan O, Raman P, Li Y, Wei JS, Zhang S, Gnanchandran J, Seeger R, Asgharzadeh S, Khan J, Diskin SJ, Maris JM, Cole KA.

Combination therapy targeting the chk1 and wee1 kinases shows therapeutic efficacy in neuroblastoma. Cancer Res 2013 Jan 15;73(2):776-84. PMID: 23135916.
Russell MR, Levin K, Rader J, Belcastro L, Li Y, Martinez D, Pawel B, Shumway SD, Maris JM, Cole KA.

RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. Proc Natl Acad Sci 2011 Feb 22;108(8):3336-41. PMID: 21289283.
Cole KA, Huggins J, Laquaglia M, Hulderman C, Bosse K, Russel M, Diskin S, Attiyeh EF, Sennett R, Norris G, Laudenslager M, Wood A, Mayes PA, Jagannathan J, Winter C, Mosse YP, Maris JM.