Sogol Mostoufi-Moab Research Program

Led by Sogol Mostoufi-Moab, MD, researchers in the Mostoufui-Moab Research Program are studying the long term late effects of hematopoietic stem transplantation (HSCT) on pediatric patients with benign and malignant hematologic disorders. Previous studies in the Mostoufi-Moab program showed that allogeneic hematopoietic stem-cell transplantation (alloHSCT) survivors treated with total body irradiation (TBI) exhibit bone deficits and excess adiposity which can contribute to long term late treatment effects such as impaired glucose metabolism and increased risk of insulin resistance.

Additional clinical studies in the Mostoufi-Moab Research Program revealed that pediatric cancer survivors treated with alloHSCT and total body irradiation had lower bone volume, abnormal trabecular microarchitecture and were at greater risk for compression fractures.  Also, survivors exhibited markedly increased bone marrow adiposity, abnormal visceral fat distribution, sarcopenic obesity, insulin resistance, and vertebral deformities.

Future studies in the Mostoufi-Moab Research Program will continue to focus on identification of strategies to prevent and treat metabolic and skeletal complications in growing numbers of childhood alloHSCT survivors.