Wei Tong Laboratory

Led by Wei Tong, PhD, researchers in the Tong Laboratory are studying cytokine receptor signaling in hematopoietic stem/progenitor development. They’re also working to decipher the underlying molecular mechanisms by which dysregulation of these pathways contribute to the oncogenesis of certain high-risk pediatric leukemias. The long term goal of the research conducted in this laboratory is to unravel these molecular mechanisms and explore new therapeutic strategies to treat children with high-risk leukemias.

Selected Publications

MERIT40 deficiency expands hematopoietic stem cell pools by regulating thrombopoietin receptor signaling. Blood. 2015 Mar 12;125(11):1730-8. Epub 2015 Jan 30.
Rozenova Krasimira, Jiang Jing, Donaghy Ryan, Aressy Bernadette, Greenberg Roger A, Tong Wei.

ARAP3 functions in hematopoietic stem cells. PLoS One. 2014 Dec 26;9(12):e116107.
Song Yiwen, Jiang Jing, Vermeren Sonja, Tong Wei.

Lnk deficiency partially mitigates hematopoietic stem cell aging. Aging Cell. 2012 Dec;11(6):949-59. Epub 2012 Aug 27.
Bersenev Alexey, Rozenova Krasimira, Balcerek Joanna, Jiang Jing, Wu Chao, Tong Wei.