Abdominal Wall Defect Publications

The following list of publications will help you in your search for more information about abdominal wall defects, including gastroschisis and omphalocele. Most are written by members of the Richard D. Wood Jr. Center for Fetal Diagnosis and Treatment team at Children's Hospital of Philadelphia. If you are unable to obtain any of these publications, please let us know, and we will send copies to you.

Journal articles


Russell KW, Nance ML, Adzick NS, Laje P. Meconium aspiration syndrome requiring ECMO in newborns with gastroschisis: incidence and surgical outcomes. Pediatr Surg Int. 2018 Nov 16;. PMID: 30443738

Victoria T, Andronikou S, Bowen D, Laje P, Weiss DA, Johnson AM, Peranteau WH, Canning DA, Adzick NS. Fetal anterior abdominal wall defects: prenatal imaging by magnetic resonance imaging. Pediatr Radiol. 2018 Apr;48(4):499-512. PMID: 29550866 

Laje P, Fraga MV, Peranteau WH, Hedrick HL, Khalek N, Gebb JS, Moldenhauer JS, Johnson MP, Flake AW, Adzick NS. Complex gastroschisis: Clinical spectrum and neonatal outcomes at a referral center. J Pediatr Surg. 2018 Mar 14;. [Epub ahead of print] PMID: 29628208. Read the abstract.


Partridge EA, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Frequency and complications of inguinal hernia repair in giant omphalocele. J Pediatr Surg. 2015 Oct;50(10):1673-5. doi: 10.1016/j.jpedsurg.2015.05.001. Epub 2015 May 29. Read the abstract.

Peranteau WH, Tharakan SJ, Partridge E, Herkert L, Rintoul NE, Flake AW, Adzick NS, Hedrick HL. Systemic hypertension in giant omphalocele: An underappreciated association. J Pediatr Surg. 2015 Sep;50(9):1477-80. Read the abstract.

Danzer E, Gerdes M, D'Agostino JA, Bernbaum J, Hoffman C, Rintoul NE, Herkert LM, Flake AW, Adzick NS, Hedrick HL. Patient characteristics are important determinants of neurodevelopmental outcome during infancy in giant omphalocele. Early Hum Dev. 2015 Feb 9;91(3):187-193. Read the abstract.


Partridge EA, Hanna BD, Panitch HB, Rintoul NE, Peranteau WH, Flake AW, Scott Adzick N, Hedrick HL. Pulmonary hypertension in giant omphalocele infants. J Pediatr Surg. 2014 Dec;49(12):1767-70. Epub 2014 Nov 14. Read the abstract.

Tsai J, Blinman TA, Collins JL, Laje P, Hedrick HL, Adzick NS, Flake AW. The contribution of hiatal hernia to severe gastroesophageal reflux disease in patients with gastroschisis. J Pediatr Surg. 2014 Mar;49(3):395-8. doi: 10.1016/j.jpedsurg.2013.09.005.


Danzer E, Hedrick HL, Rintoul NE, Siegle J, Adzick NS, Panitch HB. Assessment of early pulmonary function abnormalities in giant omphalocele survivors. J Pediatr Surg. 2012 Oct;47(10):1811-20. Cited in PubMed; PMID 23084189.

Danzer E, Victoria T, Bebbington MW, Siegle J, Rintoul NE, Johnson MP, et al. Fetal MRI-calculated total lung volumes in the prediction of short-term outcome in giant omphalocele: preliminary findings. Fetal Diagn Ther. 2012;31(4):248-53. Epub 2012 Apr 27.


Danzer E, Gerdes M, D’Agostino J, Bernbaum J, Siegle J, Hoffman C, Rintoul NE, Liechty KW, Adzick NS, Flake AW, Hedrick HL. Prospective, interdisciplinary follow-up of children with prenatally diagnosed giant omphalocele: short-term neurodevelopmental outcome. J Pediatr Surg 45(4): 718-723. Cited in PubMed; PMID 20385277.


Victoria T, Kramer SS, Markowitz R, Servaes S, Mong A, Jaramillo D, Adzick NS. Esophageal obstruction and intracardiac "mass" in association with omphalocele closure. J Pediatr Surg. 2009 Feb;44(2):448-50.


Tiblad E, Wilson RD, Carr M, Flake AW, Hedrick H, Johnson MP, Bebbington MW, Mann S, Adzick NS. OEIS sequence—a rare congenital anomaly with prenatal evaluation and postnatal outcome in six cases. Prenat Diagn. 2008 Feb;28(2):141-7.

Badillo AT, Hedrick HL, Wilson RD, Danzer E, Bebbington MW, Johnson MP, Liechty KW, Flake AW, Adzick NS. Prenatal ultrasonographic gastrointestinal abnormalities in fetuses with gastroschisis do not correlate with postnatal outcomes. J Pediatr Surg. 2008 Apr;43(4):647-53.

Mann S, Blinman TA, Douglas Wilson R. Prenatal and postnatal management of omphalocele. Prenat Diagn. 2008 Jul;28(7):626-32. Review.


Netta DA, Wilson RD, Visintainer P, Johnson MP, Hedrick HL, Flake AW et al. Gastroschisis: growth patterns and a proposed prenatal surveillance protocol. Fetal Diagn Ther. 2007;22:352-57.


Danzer E, Layne M, Gorman T, Radu A, Adzick NS, Flake A. Gastroschisis in mice lacking aortic carboxypeptidase-like protein is associated with a defect in neuromuscular development restricted to the eviscerated intestine. J American College of Surgeons. 2005; 201:S52.


Wilson RD, Johnson MP. Congenital abdominal wall defects: an update. Fetal Diagn Ther. 2004;19:385-98.

Midrio P, Faussone-Pellegrini MS, Vannucchi MG, Flake AW. Gastroschisis in the rat model is associated with a delayed maturation of intestinal pacemaker cells and smooth muscle cells. Journal of Pediatric Surgery. 2004;39:1541-47.

Biard JM, Wilson RD, Johnson MP, Hedrick HL, Flake AW, Crombleholme TM, et al. Prenatally diagnosed giant omphaloceles: short and long term outcomes. Prenatal Diagnosis. 2004; 24:434-39.


Vannucchi MG, Midrio P, Flake AW, Faussone-Pellegrini MS. Neuronal differentiation and myenteric plexus organization are delayed in gastroschisis. An immunohistochemical study in a rat model. Neuroscience Letters. 2003; 339:77-81.


Correia-Pinto J, Tavares ML, Baptista MJ, Henriques-Coelho T, Estevo-Costa J, Flake AW, Leite-Moreira AF. Meconium dependence of bowel damage in gastroschisis. Journal of Pediatric Surgery 37:31-36, 2002. 


Bealer JF, Graf J, Bruch SW, Adzick NS, Harrison MR. Gastroschisis increases small bowel nitric oxide synthase activity. J Pediatr Surg. 1996; 31:1043-46.


Pryde PG, Bardicef M, Klein M, Treadwell MC, Johnson MP, Isada NB, et al. Gastroschisis: can ultrasound predict infant outcomes, and should it be used to alter obstetrical management? Obstet Gynecol. 1994; 84:505-10.

Stringer MD, Adzick NS, Harrison MR. Mode of delivery and outcome of neonates with gastroschisis. Am J Ob Gyn. 1994; 171:869.

Babcook CJ, Hedrick MH, Filly RA, Goldstein RB, Callen PW, Harrison MR, et al. Gastroschisis: can sonography of the fetal bowel accurately predict postnatal outcome? J Ultrasound in Med. 1994; 13:701-6.


Blessed WB, Coughlin J, Johnson MP, Evans MI, Jewell MR, Goyert GL, et al. Immediate delivery room repair of fetal abdominal wall defects. Fetal Diagnosis and Therapy.1993; 8(3): 203-8.

Saleh AA, Isada NB, Johnson MP, Sokol RJ, Dombrowski MP, Evans MI. Amniotic fluid acetylcholinesterase is found in gastroschisis but not omphalocele. Fetal Diagnosis and Therapy. 1993; 8(3): 168-70.


deLorimier AA, Adzick NS, Harrison MR. Amnion inversion in the treatment of giant omphalocele. J Pediatr Surg, 1991; 26:804-7.


Flake AW, Harrison MR, Sauer L, Adzick NS, Krummel TM, Laberge JM: Auxiliary transplantation of the fetal liver II. A functional evaluation of an intra-abdominal model. J Pediatr Surg.1987; 22:559-65.

Langer JC, Harrison MR, Adzick NS, Longaker MT, Crombleholme TM, Golbus MS, et al. Perinatal management of the fetus with an abdominal wall defect. Fetal Therapy.1987; 2:216-21.


Glick PL, Harrison MR, Adzick NS, Filly RA, Callen PW. The missing link in the pathogenesis of gastroschisis. J Pediatr Surg.1985; 20:406-9.

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