Prospective Outcomes in Monochorionic Pregnancies

Principal Investigator: Nahla Khalek, MD, MPH

Monochorionic twin gestations (twins that share a placenta) represent a subgroup of multiple pregnancies that are at an especially high risk for poor perinatal outcomes. The Center for Fetal Diagnosis and Treatment at The Children’s Hospital of Philadelphia (CHOP) has managed a large number of complicated monochorionic twin gestations since 1995. Through ongoing research, we continuously seek to expand our understanding of the different problems that can occur as a result of monochorionic pregnancies.

Our team is conducting an ongoing study to assess outcomes in complicated monochorionic pregnancies affected by twin-twin transfusion syndrome (TTTS), twin reversed arterial perfusion sequence (TRAP), selective intrauterine growth restriction (sIUGR), conjoined twins, and other anomalies that undergo evaluation and/or treatment at CHOP. As part of the study, investigators review medical records from initial evaluation at CHOP until 6 months of age. The goal is to collect as much information as we can about mothers and twins so future affected families may benefit from advanced knowledge of these conditions and their complications.

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