When your child has eosinophilic esophagitis (EoE) or a related eosinophilic disorder, finding the right care matters. At Children’s Hospital of Philadelphia (CHOP), families come to us for answers, experience and compassionate care — all in one place.

Our Center for Pediatric Eosinophilic Disorders is a national and international leader in diagnosing, treating and researching eosinophilic conditions in children. We care for more children with these disorders than any center in the world, giving our team unmatched experience and insight. 

Nationally ranked, known around the world

CHOP’s Center for Pediatric Eosinophilic Disorders is recognized worldwide for excellence in care, treatment and research for children with EoE and related conditions. Each year, we care for more than 1,500 children, making us the largest pediatric eosinophilic disorders program globally.

Our Center is part of CHOP’s Divisions of Gastroenterology, Hepatology and Nutrition and Allergy and Immunology, both consistently ranked among the nation’s best by U.S. News & World Report’s Honor Roll of Best Children’s Hospitals.

EoE at CHOP: By the Numbers

Key metrics provided by the Center for Pediatric Eosinophilic Disorders (as of 2025)

A team built around your child

Your child’s care is led by a dedicated team of pediatric specialists in gastroenterology, allergy and immunology, working together. This core team partners closely with: 

• Skilled pediatric nurses 
• Registered dietitians and nutritionists 
• Psychologists and social workers 
• Pathologists with expertise in eosinophilic disease 

This team-based approach means your child receives coordinated, comprehensive care — and your family gets clear guidance and support.  

Expertise across all eosinophilic disorders

Eosinophilic disorders occur when too many eosinophils (a type of white blood cell) build up in body tissues, causing inflammation and damage. 

While eosinophilic esophagitis (EoE) — inflammation of the esophagus — is the most common diagnosis we treat, our specialists also care for children with more complex or rare conditions, including: 

• Eosinophilic gastritis (EoG) – inflammation of the stomach 
• Eosinophilic enteritis (EoN) – inflammation of the small intestine 
• Eosinophilic colitis (EoC) – inflammation of the large intestine 
• Hypereosinophilic syndrome (HES) – a rare condition involving persistently high eosinophil levels that can affect organs such as the heart and lungs 

Families often come to CHOP after struggling to get answers elsewhere. Our depth of experience allows us to diagnose and treat the full spectrum of eosinophilic disorders — even when symptoms are complex or unclear. 

Advancing care through research

Thirty years ago, eosinophilic disorders were virtually unknown and poorly understood. Today, EoE is one of the most commonly diagnosed chronic inflammatory conditions of the gastrointestinal tract. 

CHOP physician-scientists help drive that progress. By combining bedside care with laboratory research, we continue to refine how these conditions are diagnosed, monitored and treated. 

Our research goals include: 

• Helping more children achieve and maintain disease remission 
• Expanding access to less invasive diagnostic tools 
• Finding alternative screenings to reduce the need for repeated endoscopies when possible 
• Developing more personalized treatment approaches

Leading the way in less invasive diagnosis

At this time, there is no simple blood test to diagnose EoE. Traditional endoscopy — typically performed under anesthesia — remains an important tool, but repeated procedures can be stressful for children and families. CHOP is helping change that.   

Transnasal Endoscopy (TNE)

For select patients, CHOP offers transnasal esophagogastroduodenoscopy (TNE) — a non-sedated procedure in which a thin scope is passed through the nose to examine the esophagus and stomach. 

• Performed on more than 100 children in the past 18 months 
• Offered to children ages 7 and older who can remain still 
• Avoids anesthesia and allows for quicker recovery  

Esophageal String Test (Pilot Program)

We are also piloting the esophageal string test, a less invasive option that allows clinicians to detect signs of eosinophilic inflammation without endoscopy. This test involves swallowing a capsule attached to a string, which is later analyzed in the lab.  

Research that directly improves care

Current investigations at CHOP include: 

• Studying how cell signaling contributes to tissue changes in EoE 
• Using organoid models from biopsies to improve medication delivery 
• Evaluating biologic therapies, such as dupilumab, for gastric and intestinal eosinophilic disorders 
• Developing blood-based and immune assays to help identify food triggers 

This work helps move discoveries from the lab to your child’s care.

Convenient locations across the region

Families can access care from the Center for Pediatric Eosinophilic Disorders are four locations in Pennsylvania and New Jersey: 

• Buerger Center for Advanced Pediatric Care – CHOP’s Philadelphia Campus in University City 
• Isaacman Family Specialty Care & Surgery Center – Brandywine Valley (Glen Mills) 
• CHOP Specialty Care – King of Prussia 
• CHOP Specialty Care – Princeton at Plainsboro