Complex Biology of Hyperinsulinism May Offer Clues to Better Treatment
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Studying cells from children born with hyperinsulinism, CHOP experts discover events at the cellular level that may lead to new treatments for this rare disease.
Congenital Hyperinsulinism Center News and Updates
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CHOP Article Highlights Three Novel Cases of HNF HI
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Read a brief description about three novel cases of HI caused by mutations in the MODY (maturity-onset diabetes of youth) genes, HNF1A and HNF4A. Two of the cases are the first to report HNF1A mutations as a cause of congenital HI.
HI Center Founder Charles Stanley, MD, Receives Lifetime Achievement Award
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Charles Stanley, MD, the founding director of the Congenital Hyperinsulinism Center at CHOP, was presented with a lifetime achievement award by Congenital Hyperinsulinism International (CHI) at the Sugar Soiree in New York City in November.
Near-total Pancreatectomy Means Eventual Diabetes
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CHOP researchers, led by endocrinologists Katherine Lord, MD, and Diva D. De León-Crutchlow, MD, MSCE, studied the outcomes of 121 patients who had undergone a pancreatectomy. They found that 36 percent later developed diabetes.
HI Center Names New Director of Inpatient Care
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CHOP's Congenital Hyperinsulism Center taps David R. Langdon, MD, to be director of inpatient service as former director Andrew Palladino, MD, moves to HI outpatient clinic.
Sometimes, HI Can Fade Away
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At 4 years old, Leila is proof that in some children hyperinsulinism (HI) is transient: She outgrew it.
The Right Hospital for a One-in-a-Billion Child
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Jaylene was born with Beckwith-Wiedemann syndrome (BWS), a rare genetic condition. She had a near-total pancreatectomy at 9 weeks old.
Focal vs. Diffuse Patients: Comparing Outcomes
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Researchers at CHOP’s HI Center conducted a study comparing the clinical features, treatments and short-term outcomes of children with HI who underwent pancreatectomies.
Clinician’s Tip: Oral Feeding in Children with HI and BWS
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An infant with hyperinsulinism (HI) and Beckwith-Wiedemann syndrome (BWS) faces unique challenges with oral feeding.
Pilot Study: Investigational Drug Shows Promise for Diffuse HI Patients
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CHOP has found that an investigational drug could point to the first potential medical treatment for children with a type of HI.