Our GEM Research

View highlights of recent publications from the Gastrointestinal Epithelium Modeling Program at Children's Hospital of Philadelphia.

Chatterji P, Williams PA, Whelan KA …Hamilton K. Posttranscriptional Regulation of Colonic Epithelial Repair by RNA Binding Protein. IMP1/IGF2BP1. EMBO reports (2019) 20:e47074.

Karakasheva T, Kijima T, Shimonosomo M, et. al. Generation and Characterization of Patient‐Derived Head and Neck, Oral, and Esophageal Cancer Organoids. Published April 15, 2020 on Current Protocols: https://doi.org/10.1002/cpsc.109

Kasagi Y, Chandramouleeswaran P, Whelan KA, … Muir A. The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial Changes. CMGH, 5(3), p. 333-352, Jan. 2, 2018.

Kelsen JR, Dawany N, Conrad MA … Sullivan KE, Hamilton KE. Colonoids From Patients With Pediatric Inflammatory Bowel Disease Exhibit Decreased Growth Associated With Inflammation Severity and Durable Upregulation of Antigen Presentation Genes. Published June 16, 2020 in Inflammatory Bowel Diseases, izaa145: https://doi.org/10.1093/ibd/izaa145

Nakagawa H, Kasagi Y, Karakasheva TA …Hamilton K, Muir A. Modeling Epithelial Homeostasis and Reactive Epithelial Changes in Human and Murine Three‐Dimensional Esophageal Organoids. Published Feb. 17. 2020, on Current Protocols: https://doi.org/10.1002/cpsc.106.