Pediatric Kidney Stone Center Clinical Studies

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The purpose of this study is to determine how what you eat and drink (your diet), antibiotics you take, and the bacteria that live in your gut (microbiome) contribute to developing kidney stones. Kidney stone disease, known as nephrolithiasis, is also influenced by products of metabolism (metabolites) that are found in your urine. These factors will be examined in participants at least 4 years of age. Each participant will completed three 24-hour dietary recalls and will provide one stool sample and up to two urine samples. The information from this study will help doctors find new metabolic pathways that can be used for treatment of kidney stones.

Pediatric KIDney Stone (PKIDS) Care Improvement Network

Kidney stones are one of the fastest growing health conditions among children, adolescents, and young adults. The rapid increase over a short period of time has resulted in a large number of pediatric patients who require surgery to remove kidney stones with very little information available to guide selection of treatment options. There are three alternative approaches to remove kidney stones: ureteroscopy (an endoscopic outpatient procedure), shockwave lithotripsy (a noninvasive outpatient procedure), or percutaneous nephrolithotomy (a minimally invasive surgery with a short hospital stay). This study will compare stone clearance (a primary determinant of painful stone passage, Emergency Department visits, and surgical retreatment) and patients’ experiences after ureteroscopy, shockwave lithotripsy and percutaneous nephrolithotomy for patients 8 to 21 years of age. The findings from this study will provide information that helps pediatric patients and their caregivers make individualized decisions on selecting the most appropriate surgical treatment option.