Prevention of Urinary Stones with Hydration (PUSH) Study
The prevalence of kidney stones in adults and children has nearly doubled in the past 15 years. The Prevention of Urinary Stones with Hydration (PUSH) study is testing the effect of a strategy to help patients with kidney stones maintain a high enough fluid intake to prevent stone recurrence.
For the trial, Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have joined together as a single site within the Urinary Stone Disease Research Network (USDRN), a research network sponsored by the National Institutes of Health (NIH).
All participants will receive a "smart" water bottle that measures fluid consumption and connects to a smartphone app.
The primary goal of PUSH is to determine whether personalized fluid goals (i.e. a fluid prescription), a program of financial incentives, and personalized coaching to develop feasible strategies to drink sufficient fluids will reduce kidney stone recurrence over a two-year period.
PUSH participants must be 12 years of age or older, have had passed a stone or had surgery for a stone in the past three years, have a low urine amount (measured over 24 hours), own a smartphone, and meet other eligibility criteria.
For more information, visit the PUSH ClinicalTrials.gov page or email PUSH@email.chop.edu to learn how to participate in the PUSH trial.
Principal investigators at CHOP-Penn Medicine site:
- Greg Tasian, MD, MSc, MSCE, a pediatric urologist and epidemiologist at CHOP
- Peter Reese, MD, MSCE, a nephrologist and epidemiologist at Penn Medicine