E. Bryan Crenshaw, PhD

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E. Bryan Crenshaw, PhD, is the director of Basic Science Research with the Division of Otolaryngology (ENT) and a scientist with the Mammalian Neurogenetics Group at Children's Hospital of Philadelphia.

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training


Postdoctoral Fellow - Laboratory of M. Geoffrey Rosenfeld, Howard Hughes Medical Institute, University of California, San Diego, CA

Undergraduate Degree

SB in Life Sciences - Massachusetts Institute of Technology, Cambridge, MA

Graduate Degree

PhD in Biology - University of California at San Diego, San Diego, CA

Titles and Academic Titles

Director of Basic Science Research, Division of Otolaryngology

Scientist, Mammalian Neurogenetics Group

Adjunct Associate Professor of Otorhinolaryngology, Head and Neck Surgery, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Research Interests

Using state-of-the-art mouse molecular genetic approaches to characterize mammalian development. Specifically, characterizing the role of specific genes during auditory and vestibular development.




Pennington JW, Ruth B, Italia MJ, Miller J, Wrazien, Loutrel JG, Crenshaw EB III, White PS: Harvest: A web-based biomedical data discovery and reporting application development platform. Journal American Medical Informatics Association October 16 2013 Notes: Published Online First: 16 October 2013 doi:10.1136/amiajnl-2013-001825. 

Italia MJ, Pennington JW, Ruth B, Wrazien S, Loutrel JG, Crenshaw EB III, Miller J, White PS: Harvest: A web-based biomedical data discovery and reporting application development platform. AMIA - Joint Summits on Translational Science Proceedings 2013: 82, March 18 2013 Notes: eCollection 2013. PMCID: PMC3814457


Hazen VM, Andrews MG, Umans L, Crenshaw EB III, Zwijsen A, Butler SJ: BMP receptor-activated Smads confer diverse functions during the development of the dorsal spinal cord. Developmental Biology 367(2), 2012 216-227.

John A, Brylka H, Wiegreffe C, Simon R, Liu P, Juttner R, Crenshaw III, Luyten FP, Jenkins NA, Copeland NG, Birchmeier C,. Britsch S: Bcl11a is required for neuronal differentiation and sensory circuit formation in dorsal spinal cord development. Development 139(10): 1831-41, 2012.

Coate TM, Ryan AK, Raft S, Crenshaw EB III, Kelley MW: Otic mesenchyme cells regulate the fasciculation of spiral ganglion neurons through a Pou3f4/EphA4 signaling pathway. Neuron 73: 49-63, 2012.



Masino, AJ, Bernal, O, Fowlie, GE, Germiller JA, Pennington, JW, and EB Crenshaw: CT Text Report Outcome Classification with Machine Learning and NLP. Proceedings of the AMIA Meeting 2014 Notes: In press.


Germiller JA, Marsh R, Cohn S, Reinders M, Italia M, Pennington J, Ruth B, White P, Peterson J, Krantz ID, Crenshaw EB III: "AudGenDB: A Public, Internet-Based, Audiologic/ Otologic/ Genetic Database for Pediatric Hearing Research" Oral presentation at the 34th Annual Midwinter Meeting, Association for Research in Otolaryngology, Baltimore, MD February 19-23 2011.




Montcouquiol M, Crenshaw III, EB, Kelley MW: Non-canonical Wnt signaling and neural polarity. Annual Review of Neuroscience 29: 363-386, Jul 2006.


Crenshaw III, EB: Mutations of the Brn4 / Pou3f4 locus in mouse and man. Handbook of Mouse Auditory Research: From Behavior to Molecular Biology. J. Willot (eds.). CRC Press, Page: 617-620, 2001.


Crenshaw III, EB, Swanson LW, Rosenfeld MG, Russo AR: Transgenic mouse technology: Applications to the study of neurobiology Techniques for the Genetic Analysis of Brain and Behavior: Focus on the Mouse. D. Goldowitz, D. Wahlsten and R. Wimer (eds.). Elsevier, Page: 75-94, 1992.


Ryan AF, Crenshaw III, EB, Simmons DM: Gene expression in normal and abnormal inner ears. Annals of the New York Academy of Science 630: 129-132, 1991.


Ingraham HI, Albert V, Chen R, Crenshaw III, EB, Elsholtz HP, He X, Kapiloff MS, Mangalam HJ, Swanson LW, Treacy MN, Rosenfeld MG: A family of POU-domain and Pit-1 tissue-specific transcription factors in pituitary and neuroendocrine development Annual Review of Physiology 52: 773-791, 1990.


Rosenfeld MG, Crenshaw, EB, Emeson RE, Leff S, Lira S, Nelson C, Nelson C, Russo A: Transcriptional and post-transcriptional strategies in neuroendocrine gene expression. Developmental Biology: A Comprehensive Synthesis. L.W. Browder (eds.). Plenum Press (New York), 5: 317-334, 1988.

Rosenfeld MG, Crenshaw III, EB, Lira SA, Borelli E, Heyman R, Swanson LW, Evans RM: Transgenic mice: Applications to the study of the nervous system. Annual Review of Neuroscience 11: 353-372, 1988.

Rosenfeld MG, Glass CK, Adler S, Crenshaw III, EB, He X, Lira SA, Elsholtz HP, Mangalam HJ, Holloway JM, Nelson C, Albert VR: Response and binding elements for ligand-dependent positive transcription factors integrate positive and negative regulation of gene expression. Cold Spring Harbor Symposium, Quantitative Biology 53: 545-556, 1988.


Rosenfeld MG, Nelson CN, Crenshaw III, EB, Elsholtz HP, Lira SA, Mangalam HJ, Franco R, Waterman M, Weinberger C, Hollenberg SM, Giguere V, Evans RM: Developmental and hormonal regulation of neuroendocrine gene transcription. Recent Progress in Hormone Research. Academic Press, 43: 499-534, 1987.

Rosenfeld MG, Leff S, Russo A, Crenshaw III, EB, Nelson C, Franco R, Lira S, Evans RM: Regulation of neuroendocrine gene expression. Transcriptional Control Mechanisms Granner (eds.). Alan R. Liss, 52: 369-378, 1987.


Leff SE, Nelson C, Crenshaw, EB, Elsholtz H, Mangalam H, Russo A, Evans RM, Rosenfeld MG: Transcriptional and post-transcriptional regulation of neuroendocrine gene expression Advances in Gene Technology: Molecular Biology of the Endocrine System. Puett (eds.). ICSU Short Reports, 4: 6-9, 1986.


Van de Water L, Wagner DD, Crenshaw III, EB, Hynes RO: Fibronectin-dependent endocytosis by macrophage-like (P388D1) and fibroblastic (NIL8) cells. Cellular Recognition. Frazier, Glaser, and Gottlieb (eds.). Alan R. Liss (New York), Page: 869-878, 1982.

Awards and Honors

1993-1995, Basil O'Connor Starter Scholar Award, March of Dimes

1992, Young Investigator Award from the Earl M. Bane Charitable Trust

1989-1991, National Institutes of Health Postdoctoral Fellowship

1982, John Asinari Award for Undergraduate Research, MIT

1982, Phi Sigma Kappa Terrill Graduate Fellowship

Editorial and Academic Positions

Academic and institutional committees

2011-present, Academic Review Committee, Graduate Group in Neuroscience

Leadership and Memberships

Memberships in professional organizations


2013-present, NIH CDRC Study Section

2011-present, Hearing Restoration Project, Hearing Health Foundation

2006-present, Society for Neuroscience

2003-present, National Organization for Hearing Research-Scientific Review Committee

1998-present, Association for Research in Otolaryngology