Brian N. Harding, MA, DPhil, BM, BCh, FRCPath

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Brian N. Harding, MA, DPhil, BM, BCh, FRCPath, is a Pediatric Neuropathologist at Children's Hospital of Philadelphia.

Areas of Expertise: Epilepsy, Developmental and neurometabolic diseases
Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Background

Dr. Harding is a pediatric neuropathologist with special interest in epilepsy, developmental and neurometabolic diseases.

Education and Training

Graduate Degree

BMBCh - University of Oxford & St. George's Hospital Medical School, London, UK
DPhil - Department of Anatomy, University of Oxford, Oxford, England
MA in Animal Physiology - Worcester College, University of Oxford, Oxford, England

Titles and Academic Titles

Attending, Division of Neuropathology

Professor of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Research Interests

Developmental neurobiology

Publications

Papers

2016

Barth PG, Aronica E, Fox S, Fluiter K, Weterman MA, Poretti A, Miller DC, Boltshauser E, Harding B, Santi M, Baas F: Deregulated expression of EZH2 in congenital brainstem disconnection. Neuropathol Appl Neurobiol November 25 2016 Notes: Epub ahead of print.

Harding BN, Moccia A, Drunat S, Soukarieh O, Tubeuf H, Chitty LS, Verloes A, Gressens P, El Ghouzzi V, Joriot S, Di Cunto F, Martins A, Passemard S, Bielas SL: Mutations in Citron Kinase Cause Recessive Microlissencephaly with Multinucleated Neurons. Am J Hum Genet. 99(2): 511-20, August 2016.

Harding B, Vossough A, Goldberg E, Santi M: Pontine tegmental cap dysplasia: neuropathological confirmation of a rare clinical/radiological syndrome. Neuropathology and Applied Neurobiology 42(3): 301-6, April 2016.

Gmuca S, Boos MD, Treece A, Narula S, Billinghurst L, Bhatti T, Laje P, Perman MJ, Vossough A, Harding B, Burnham J, Banwell B.: Degos disease mimicking primary vasculitis of the CNS. Neurol Neuroimmunol Neuroinflamm 3(2): E206, Feb 2 2016.

Rajakulendran S, Pitceathly RD, Taanman JW, Costello H, Sweeney MG, Woodward CE, Jaunmuktane Z, Holton JL, Jacques TS, Harding BN, Fratter C9, Hanna MG, Rahman S: A Clinical, Neuropathological and Genetic Study of Homozygous A467T POLG-Related Mitochondrial Disease. PLoS One 11(1): e0145500, Jan 6 2016.

2015

Skjei KL, Church EW, Harding BN, Santi M, Holland-Bouley KD, Clancy RR, Porter BE, Heuer GG, Marsh ED: Clinical and histopathological outcomes in patients with SCN1A mutations undergoing surgery for epilepsy. J Neurosurg Pediatr 16(6): 668-74, Dec 2015.

Jinks RN, Puffenberger EG, Baple E, Harding B, Crino P, Fogo AB, Wenger O, Xin B, Koehler AE, McGlincy MH, Provencher MM, Smith JD, Tran L, Al Turki S, Chioza BA11, Cross H, Harlalka GV, Hurles ME, Maroofian R, Heaps AD, Morton MC, Stempak L, Hildebrandt F, Sadowski CE, Zaritsky J, Campellone K, Morton DH, Wang H, Crosby A, Strauss KA.: Recessive nephrocerebellar syndrome on the Galloway-Mowat syndrome spectrum is caused by homozygous protein-truncating mutations of WDR73. Brain 138: 2173-90, Aug 2015.

Arthurs OJ, Thayyil S, Pauliah SS, Jacques TS, Chong WK, Gunny R, Saunders D, Addison S, Lally P, Cady E, Jones R, Norman W, Scott R, Robertson NJ, Wade A, Chitty L, Taylor AM, Sebire NJ; Magnetic Resonance Imaging Autopsy Study (MaRIAS) Collaborative Group.: Diagnostic accuracy and limitations of post-mortem MRI for neurological abnormalities in fetuses and children. Clin Radiol.  70(8): 872-80, Aug 2015.

Arthurs OJ, Thayyil S, Owens CM, Olsen OE, Wade A, Addison S, Jones R, Norman W, Scott RJ, Robertson NJ, Taylor AM, Chitty LS, Sebire NJ; Magnetic Resonance Imaging Autopsy Study (MaRIAS) Collaborative Group.: Diagnostic accuracy of post mortem MRI for abdominal abnormalities in foetuses and children. Eur J Radiol. 84(3): 474-81, Mar 2015.

Harding BN1, Kariya S, Monani UR, Chung WK, Benton M, Yum SW, Tennekoon G, Finkel RS.: Spectrum of neuropathophysiology in spinal muscular atrophy type I. J Neuropathol Exp Neurol 74(1): 15-24, Jan 2015.

Abstracts

2016

Harding BN, Moccia A, Chtty L and Bielas S: Microlissencephaly with multinucleated neurons results from failed cytokinesis due to truncating mutations in Citron kinase. Clin Neuropath 35, 2016.

Harding B, Moccia A, Chitty L, Bielas S: Truncating mutations in Citron-Kinase: a cause of micro-lissencephaly with multinucleated neurons. JNEN 75, 2016.

Books

Books

2013

Ellison, D., Love, S., Chimelli, L., Harding, B., Vinters, H. V., Brandner S., Yong WH: Neuropathology. A reference text of CNS pathology, 3rd edition. London: Mosby 2013.

2004

Golden, J. A., Harding, B. N.: Developmental Neuropathology. ISN Press Basel  2004.

Ellison, D., Love, S., Chimelli, L., Harding, B., Vinters, H. V.  : Neuropathology. A reference text of CNS pathology, 2nd edition.  London: Mosby 2004.

1998

Ellison, D., Love, S., Chimelli, L., Harding, B., Lowe, J., Roberts, G. W., Vinters, H. V.: Neuropathology. A reference text of CNS pathology. London: Mosby 1998.

Chapters

2014

Encha-Razavi,F, Folkerth, R, Harding, B, Vinters, H, Golden, J: Congenital Malformations and Perinatal Diseases. Escourolle and Poirier's Manual of Basic Neuropathology. Gray, F, Duyckaerts, C, De Girolami, U (eds.). Oxford University Press, 5th Edition, JAN 2014.

2008

Harding, B., Surtees, R.: Metabolic and neurodegenerative diseases of childhood.  Greenfield's Neuropathology, 8th Ed. Ellison, D., Love, J., Louis, D. (eds.). London: Arnold, Page: 481-514, 2008.

Harding, B., Copp, A.: Malformations. Greenfield's Neuropathology, 8th Ed. Ellison, D., Love, J., Louis, D. (eds.). Hodder Arnold, Page: 335-480, 2008.

2004

Encha-Razavi, F., Folkerth, R. D., Harding, B.: Congenital malformations and perinatal diseases.  Basic Neuropathology. Gray, F., De Girolami, U., Poirier, J. (eds.). Butterworth.  Philadelphia, PA. Page: 249-268, 2004.

2003

Harding, B.: Spinal muscular atrophy.  Neurodegeneration: The molecular pathology of dementia and movement disorders. Dickson, D., Switzerland, B. (eds.). ISN Neuropath Press, Page: 372-375, 2003.

Harding B., Surtees, R.: Metabolic and neurodegenerative diseases of childhood.  Greenfield's Neuropathology 7th Ed. Graham, D., Lantos, P. L. (eds.). London:Arnold, Page: 372-375, 2003.

2002

Harding, B., Copp, A. J. : Malformations. Greenfield's Neuropathology, 7th Ed. Graham, D. I., Lantos, P. L. (eds.). Arnold, Page: 357-384, 2002.

1997

Harding, B., Copp, A. J.: Malformations.  Greenfield's Neuropathology 6th Ed. Graham, D. I., Lantos, P. L., (eds.). London: Arnold, Page: 397-533, 1997.

Brett, E. M., Harding, B.: Intracranial and spinal cord tumours.  Paediatric Neurology. Brett, E. M. (eds.). New York: Churchill Livingstone, Page: 537-570, 1997.

Brett, E. M., Harding, B.: Hydrocephalus and congenital anomalies of the nervous system other than myelomeningocele.  Paediatric Neurology. Brett, E. M. (eds.). New York: Churchill Livingstone, Page: 493-536, 1997.

1996

Harding, B.: Gray matter heterotopia.  Dysplasias of cerebral cortex and epilepsy. Guerrini, R., Andermann, F., Canapicchi, R., Roger, J., Zifkin, B. G., Pfanner, P. (eds.). Philadelphia, New York: Lippincott-Raven, Page: 81-88, 1996.

1995

Patton, M. A., Giannelli, F., Francis, A. J., Baraitser, M., Harding, B., Williams, A. J.: Early onset Cockayne's syndrome: case reports with neuropathological and fibroblast studies.  Congenital malformation syndrome. Donnai, D., Winter, R. M. (eds.). London: Chapman & Hall, Page: 155-162, 1995.

1994

Harding, B.: The Brain. Diseases of the Fetus and Newborn. Reed, G. B., Claireaux, A. E., Cockburn, F. (eds.). London: Chapman and Hall, Page: 413-464, 1994.

1993

Weller, R. O., Kida, S., Harding, B.: Aetiology and Pathology of Hydrocephalus.  Hydrocephalus Schurr, P. H., Polkey, C. E. (eds.). London: Oxford University Press, Page: 521-538, 1993.

1992

Harding, B.: Malformations of the nervous system. Greenfield's Neuropathology 5th Ed. Hume Adams, J., Duchen, L. W. (eds.). London: Edward Arnold, Page: 521-638, 1992.

1990

Harding, B. N. : Rosenthal fibers in Alexander's disease. Journal of Childhood Neurology  5: 259-260, 1990.

1989

Harding, B. N. : The Brain. Diseases of the Fetus and Newborn. Reed, G. B., Claireaux, A. E., Bain, A. D. (eds.). London: Chapman and Hall, Page: 169-216, 1989.

Editorial and Academic Positions

Editorial Positions

2002-present, Editorial Board, Brain Pathology

Leadership and Memberships

International

1990-present, Royal College of Pathologists (UK) scheme (Member)
1981-present, British Neuropathology Society (Member)

National

1989-present, American Association of Neuropathologists (Member)