Dr. Harding is a pediatric neuropathologist with special interest in epilepsy, developmental and neurometabolic diseases.
Education and Training
BMBCh - University of Oxford & St. George's Hospital Medical School, London, UK
DPhil - Department of Anatomy, University of Oxford, Oxford, England
MA in Animal Physiology - Worcester College, University of Oxford, Oxford, England
Titles and Academic Titles
Attending, Division of Neuropathology
Professor of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania
Departments and Services
Barth PG, Aronica E, Fox S, Fluiter K, Weterman MA, Poretti A, Miller DC, Boltshauser E, Harding B, Santi M, Baas F: Deregulated expression of EZH2 in congenital brainstem disconnection. Neuropathol Appl Neurobiol November 25 2016 Notes: Epub ahead of print.
Harding BN, Moccia A, Drunat S, Soukarieh O, Tubeuf H, Chitty LS, Verloes A, Gressens P, El Ghouzzi V, Joriot S, Di Cunto F, Martins A, Passemard S, Bielas SL: Mutations in Citron Kinase Cause Recessive Microlissencephaly with Multinucleated Neurons. Am J Hum Genet. 99(2): 511-20, August 2016.
Harding B, Vossough A, Goldberg E, Santi M: Pontine tegmental cap dysplasia: neuropathological confirmation of a rare clinical/radiological syndrome. Neuropathology and Applied Neurobiology 42(3): 301-6, April 2016.
Gmuca S, Boos MD, Treece A, Narula S, Billinghurst L, Bhatti T, Laje P, Perman MJ, Vossough A, Harding B, Burnham J, Banwell B.: Degos disease mimicking primary vasculitis of the CNS. Neurol Neuroimmunol Neuroinflamm 3(2): E206, Feb 2 2016.
Rajakulendran S, Pitceathly RD, Taanman JW, Costello H, Sweeney MG, Woodward CE, Jaunmuktane Z, Holton JL, Jacques TS, Harding BN, Fratter C9, Hanna MG, Rahman S: A Clinical, Neuropathological and Genetic Study of Homozygous A467T POLG-Related Mitochondrial Disease. PLoS One 11(1): e0145500, Jan 6 2016.
Skjei KL, Church EW, Harding BN, Santi M, Holland-Bouley KD, Clancy RR, Porter BE, Heuer GG, Marsh ED: Clinical and histopathological outcomes in patients with SCN1A mutations undergoing surgery for epilepsy. J Neurosurg Pediatr 16(6): 668-74, Dec 2015.
Jinks RN, Puffenberger EG, Baple E, Harding B, Crino P, Fogo AB, Wenger O, Xin B, Koehler AE, McGlincy MH, Provencher MM, Smith JD, Tran L, Al Turki S, Chioza BA11, Cross H, Harlalka GV, Hurles ME, Maroofian R, Heaps AD, Morton MC, Stempak L, Hildebrandt F, Sadowski CE, Zaritsky J, Campellone K, Morton DH, Wang H, Crosby A, Strauss KA.: Recessive nephrocerebellar syndrome on the Galloway-Mowat syndrome spectrum is caused by homozygous protein-truncating mutations of WDR73. Brain 138: 2173-90, Aug 2015.
Arthurs OJ, Thayyil S, Pauliah SS, Jacques TS, Chong WK, Gunny R, Saunders D, Addison S, Lally P, Cady E, Jones R, Norman W, Scott R, Robertson NJ, Wade A, Chitty L, Taylor AM, Sebire NJ; Magnetic Resonance Imaging Autopsy Study (MaRIAS) Collaborative Group.: Diagnostic accuracy and limitations of post-mortem MRI for neurological abnormalities in fetuses and children. Clin Radiol. 70(8): 872-80, Aug 2015.
Arthurs OJ, Thayyil S, Owens CM, Olsen OE, Wade A, Addison S, Jones R, Norman W, Scott RJ, Robertson NJ, Taylor AM, Chitty LS, Sebire NJ; Magnetic Resonance Imaging Autopsy Study (MaRIAS) Collaborative Group.: Diagnostic accuracy of post mortem MRI for abdominal abnormalities in foetuses and children. Eur J Radiol. 84(3): 474-81, Mar 2015.
Harding BN1, Kariya S, Monani UR, Chung WK, Benton M, Yum SW, Tennekoon G, Finkel RS.: Spectrum of neuropathophysiology in spinal muscular atrophy type I. J Neuropathol Exp Neurol 74(1): 15-24, Jan 2015.
Harding BN, Moccia A, Chtty L and Bielas S: Microlissencephaly with multinucleated neurons results from failed cytokinesis due to truncating mutations in Citron kinase. Clin Neuropath 35, 2016.
Harding B, Moccia A, Chitty L, Bielas S: Truncating mutations in Citron-Kinase: a cause of micro-lissencephaly with multinucleated neurons. JNEN 75, 2016.
Ellison, D., Love, S., Chimelli, L., Harding, B., Vinters, H. V., Brandner S., Yong WH: Neuropathology. A reference text of CNS pathology, 3rd edition. London: Mosby 2013.
Golden, J. A., Harding, B. N.: Developmental Neuropathology. ISN Press Basel 2004.
Ellison, D., Love, S., Chimelli, L., Harding, B., Vinters, H. V. : Neuropathology. A reference text of CNS pathology, 2nd edition. London: Mosby 2004.
Ellison, D., Love, S., Chimelli, L., Harding, B., Lowe, J., Roberts, G. W., Vinters, H. V.: Neuropathology. A reference text of CNS pathology. London: Mosby 1998.
Encha-Razavi,F, Folkerth, R, Harding, B, Vinters, H, Golden, J: Congenital Malformations and Perinatal Diseases. Escourolle and Poirier's Manual of Basic Neuropathology. Gray, F, Duyckaerts, C, De Girolami, U (eds.). Oxford University Press, 5th Edition, JAN 2014.
Harding, B., Surtees, R.: Metabolic and neurodegenerative diseases of childhood. Greenfield's Neuropathology, 8th Ed. Ellison, D., Love, J., Louis, D. (eds.). London: Arnold, Page: 481-514, 2008.
Harding, B., Copp, A.: Malformations. Greenfield's Neuropathology, 8th Ed. Ellison, D., Love, J., Louis, D. (eds.). Hodder Arnold, Page: 335-480, 2008.
Encha-Razavi, F., Folkerth, R. D., Harding, B.: Congenital malformations and perinatal diseases. Basic Neuropathology. Gray, F., De Girolami, U., Poirier, J. (eds.). Butterworth. Philadelphia, PA. Page: 249-268, 2004.
Harding, B.: Spinal muscular atrophy. Neurodegeneration: The molecular pathology of dementia and movement disorders. Dickson, D., Switzerland, B. (eds.). ISN Neuropath Press, Page: 372-375, 2003.
Harding B., Surtees, R.: Metabolic and neurodegenerative diseases of childhood. Greenfield's Neuropathology 7th Ed. Graham, D., Lantos, P. L. (eds.). London:Arnold, Page: 372-375, 2003.
Harding, B., Copp, A. J. : Malformations. Greenfield's Neuropathology, 7th Ed. Graham, D. I., Lantos, P. L. (eds.). Arnold, Page: 357-384, 2002.
Harding, B., Copp, A. J.: Malformations. Greenfield's Neuropathology 6th Ed. Graham, D. I., Lantos, P. L., (eds.). London: Arnold, Page: 397-533, 1997.
Brett, E. M., Harding, B.: Intracranial and spinal cord tumours. Paediatric Neurology. Brett, E. M. (eds.). New York: Churchill Livingstone, Page: 537-570, 1997.
Brett, E. M., Harding, B.: Hydrocephalus and congenital anomalies of the nervous system other than myelomeningocele. Paediatric Neurology. Brett, E. M. (eds.). New York: Churchill Livingstone, Page: 493-536, 1997.
Harding, B.: Gray matter heterotopia. Dysplasias of cerebral cortex and epilepsy. Guerrini, R., Andermann, F., Canapicchi, R., Roger, J., Zifkin, B. G., Pfanner, P. (eds.). Philadelphia, New York: Lippincott-Raven, Page: 81-88, 1996.
Patton, M. A., Giannelli, F., Francis, A. J., Baraitser, M., Harding, B., Williams, A. J.: Early onset Cockayne's syndrome: case reports with neuropathological and fibroblast studies. Congenital malformation syndrome. Donnai, D., Winter, R. M. (eds.). London: Chapman & Hall, Page: 155-162, 1995.
Harding, B.: The Brain. Diseases of the Fetus and Newborn. Reed, G. B., Claireaux, A. E., Cockburn, F. (eds.). London: Chapman and Hall, Page: 413-464, 1994.
Weller, R. O., Kida, S., Harding, B.: Aetiology and Pathology of Hydrocephalus. Hydrocephalus Schurr, P. H., Polkey, C. E. (eds.). London: Oxford University Press, Page: 521-538, 1993.
Harding, B.: Malformations of the nervous system. Greenfield's Neuropathology 5th Ed. Hume Adams, J., Duchen, L. W. (eds.). London: Edward Arnold, Page: 521-638, 1992.
Harding, B. N. : Rosenthal fibers in Alexander's disease. Journal of Childhood Neurology 5: 259-260, 1990.
Harding, B. N. : The Brain. Diseases of the Fetus and Newborn. Reed, G. B., Claireaux, A. E., Bain, A. D. (eds.). London: Chapman and Hall, Page: 169-216, 1989.
Editorial and Academic Positions
2002-present, Editorial Board, Brain Pathology
Leadership and Memberships
1990-present, Royal College of Pathologists (UK) scheme (Member)
1981-present, British Neuropathology Society (Member)
1989-present, American Association of Neuropathologists (Member)
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